Cyfip1<sup>em1Sage</sup> (cytoplasmic FMR1 interacting protein 1; CRISPR/Cas9 induced mutant 1, Sage) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cyfip1em1Sage (cytoplasmic FMR1 interacting protein 1; CRISPR/Cas9 induced mutant 1, Sage) Rattus norvegicus
Analyze
Symbol: Cyfip1em1Sage
Name: cytoplasmic FMR1 interacting protein 1; CRISPR/Cas9 induced mutant 1, Sage
RGD ID: 14985211
Description: The guide RNA (sgRNA) targeting a Protospacer Adjacent Motif (PAM) sequence within exon 7 of the rat Cyfip1gene (GGCAGATCCACAATCCATCCagg) on chromosome 1 (first 21 of 32 exons, Refseq: NC_005100.4, NM_001107517.1) was injected to Long Evans one cell embryos. The resultant mutation is 4 bp out of frame deletion in exon 7 of the rat Cyfip1, resulting an early stop codon in exon 8.
ASSOCIATED WITH abnormal brain white matter morphology; decreased myelin sheath thickness; decreased oligodendrocyte number
Type: allele  of Cyfip1  
Previously known as: Cyfip1^[em1Sage]
Is Marker For: Strains:   LE-Cyfip1em1Sage+/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility. Silva AI, etal., Nat Commun. 2019 Aug 1;10(1):3455. doi: 10.1038/s41467-019-11119-7.

Genomics


Related Rat Strains
The following Strains have been annotated to Cyfip1em1Sage
LE-Cyfip1em1Sage+/-    


Expression


Sequence

Nucleotide Sequences


Additional Information