Wfs1<sup>em3Ptsn</sup> (wolframin ER transmembrane glycoprotein; ZFN induced mutant 3) - Rat Genome Database

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Gene: Wfs1em3Ptsn (wolframin ER transmembrane glycoprotein; ZFN induced mutant 3) Rattus norvegicus
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Symbol: Wfs1em3Ptsn
Name: wolframin ER transmembrane glycoprotein; ZFN induced mutant 3
RGD ID: 149735339
Description: This allele was created in embryos from Sprague-Dawley rats (Crl: CD(SD). This allele carrys a substitution in exon 5 of the Wfs1 gene, which is predicted to result in a substitution of LQK (aa 224-226) into YCMNTI in the WFS1 protein.
ASSOCIATED WITH impaired glucose tolerance
Type: allele  of Wfs1  
Previously known as: Wfs1em3
Is Marker For: Strains:   SD-Wfs1em3Ptsn  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration. Plaas M, etal., Sci Rep. 2017 Aug 31;7(1):10220. doi: 10.1038/s41598-017-09392-x.

Genomics


Related Rat Strains
The following Strains have been annotated to Wfs1em3Ptsn


Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-07-29 Wfs1em3Ptsn  wolframin ER transmembrane glycoprotein; ZFN induced mutant 3  Wfs1em3  wolframin ER transmembrane glycoprotein; ZFN induced mutant 3  Symbol changed 629549 APPROVED