Wfs1<sup>em1Ptsn</sup> (wolframin ER transmembrane glycoprotein; ZFN induced mutant 1) - Rat Genome Database

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Gene: Wfs1em1Ptsn (wolframin ER transmembrane glycoprotein; ZFN induced mutant 1) Rattus norvegicus
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Symbol: Wfs1em1Ptsn
Name: wolframin ER transmembrane glycoprotein; ZFN induced mutant 1
RGD ID: 149735335
Description: This allele was created in embryos from Sprague-Dawley rats (Crl: CD(SD). A 27 amino acid deletion in exon 5 (aa212-238) was identified.
ASSOCIATED WITH abnormal brainstem morphology; decreased insulin secretion; decreased pancreatic beta cell mass; ASSOCIATED WITH cataract; diabetes mellitus; glucose intolerance
Type: allele  of Wfs1  
Previously known as: Wfs1em1
Is Marker For: Strains:   SD-Wfs1em1Ptsn  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration. Plaas M, etal., Sci Rep. 2017 Aug 31;7(1):10220. doi: 10.1038/s41598-017-09392-x.
2. Preventive treatment with liraglutide protects against development of glucose intolerance in a rat model of Wolfram syndrome. Toots M, etal., Sci Rep. 2018 Jul 5;8(1):10183. doi: 10.1038/s41598-018-28314-z.

Genomics


Related Rat Strains
The following Strains have been annotated to Wfs1em1Ptsn


Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-07-29 Wfs1em1Ptsn  wolframin ER transmembrane glycoprotein; ZFN induced mutant 1  Wfs1em1  wolframin ER transmembrane glycoprotein; ZFN induced mutant 1  Symbol changed 629549 APPROVED