Fah<sup>em15Dlli-/-</sup> (fumarylacetoacetate hydrolase; CRISPR/Cas9 induced mutant 15, Dlli) - Rat Genome Database

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Gene: Fahem15Dlli-/- (fumarylacetoacetate hydrolase; CRISPR/Cas9 induced mutant 15, Dlli) Rattus norvegicus
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Symbol: Fahem15Dlli-/-
Name: fumarylacetoacetate hydrolase; CRISPR/Cas9 induced mutant 15, Dlli
RGD ID: 14398826
Description: This mutation was produced by injecting Sprague Dawley embryo with CRISP/Case9 system targeting the exon 2 of rat Fah gene. The resulting mutation is line 15 with a frameshift deletion causing Fah null in homozygotes.
ASSOCIATED WITH decreased body weight; increased circulating tyrosine level; moribund; ASSOCIATED WITH liver cirrhosis; tyrosinemia type I
Type: allele  of Fah  
Is Marker For: Strains:   SD-Fahem15Dlli-/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Efficient liver repopulation of transplanted hepatocyte prevents cirrhosis in a rat model of hereditary tyrosinemia type I. Zhang L, etal., Sci Rep. 2016 Aug 11;6:31460. doi: 10.1038/srep31460.

Genomics


Related Rat Strains
The following Strains have been annotated to Fahem15Dlli-/-


Expression


Sequence

Nucleotide Sequences


Additional Information