Cd40<sup>em1Uthal</sup> (CD40 molecule; ZFN induced mutant 1, Uthal) - Rat Genome Database

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Gene: Cd40em1Uthal (CD40 molecule; ZFN induced mutant 1, Uthal) Rattus norvegicus
Symbol: Cd40em1Uthal
Name: CD40 molecule; ZFN induced mutant 1, Uthal
RGD ID: 14398461
Description: Zinc Finger Nuclease (ZFN) was utilized to knockout rat CD40 function in the embryos of SS/JrHsd rats. The target sequence (CAGCACCGACACTGCgaactcAGTGCGTGGGGCTGCCGGG) introduced an 11 bp-deletion (CTGCGAACTCA) in the third exon of the Cd40 gene, resulted in a trucated protein.
ASSOCIATED WITH decreased circulating creatinine level; decreased collagen level; decreased urine protein level
Type: allele  of Cd40  
Previously known as: Cd40^[em1Uthal]
Is Marker For: Strains:   SS-Cd40em1Uthal-/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Targeted disruption of Cd40 in a genetically hypertensive rat model attenuates renal fibrosis and proteinuria, independent of blood pressure. Haller ST, etal., Kidney Int. 2017 Feb;91(2):365-374. doi: 10.1016/j.kint.2016.08.015. Epub 2016 Sep 28.


Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Cd40em1Uthal-var1 chr3 167711248 167711258 CTGCGAACTCA - deletion Rnor_5.0

Related Rat Strains
The following Strains have been annotated to Cd40em1Uthal



Nucleotide Sequences

Additional Information