Cd40<sup>em1Uthal</sup> (CD40 molecule; ZFN induced mutant 1, Uthal)

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Gene: Cd40^em1Uthal (CD40 molecule; ZFN induced mutant 1, Uthal) Rattus norvegicus

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Symbol:	Cd40^em1Uthal
Name:	CD40 molecule; ZFN induced mutant 1, Uthal
RGD ID:	14398461
Description:	Zinc Finger Nuclease (ZFN) was utilized to knockout rat CD40 function in the embryos of SS/JrHsd rats. The target sequence (CAGCACCGACACTGCgaactcAGTGCGTGGGGCTGCCGGG) introduced an 11 bp-deletion (CTGCGAACTCA) in the third exon of the Cd40 gene, resulted in a trucated protein. ASSOCIATED WITH decreased circulating creatinine level; decreased collagen level; decreased urine protein level
Type:	allele of Cd40
Is Marker For:	Strains: SS-Cd40^em1Uthal-/-
Latest Assembly:	mRatBN7.2 - mRatBN7.2 Assembly
Position:	No map positions available.

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Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased circulating creatinine level (IMP)

decreased collagen level (IMP)

decreased urine protein level (IMP)

increased creatinine clearance (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Targeted disruption of Cd40 in a genetically hypertensive rat model attenuates renal fibrosis and proteinuria, independent of blood pressure.	Haller ST, etal., Kidney Int. 2017 Feb;91(2):365-374. doi: 10.1016/j.kint.2016.08.015. Epub 2016 Sep 28.

Genomics

Related Rat Strains

The following Strains have been annotated to Cd40^em1Uthal

SS-Cd40^em1Uthal-/-

Expression

Sequence

Nucleotide Sequences

Additional Information

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MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype