Cftr<sup>em1Sage</sup> (cystic fibrosis transmembrane conductance regulator; ZFN induced mutant 1 Sage) - Rat Genome Database

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Gene: Cftrem1Sage (cystic fibrosis transmembrane conductance regulator; ZFN induced mutant 1 Sage) Rattus norvegicus
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Symbol: Cftrem1Sage
Name: cystic fibrosis transmembrane conductance regulator; ZFN induced mutant 1 Sage
RGD ID: 14392814
Description: A 16 bp deletion in exon 3 of the Cystic Fibrosis transmembrane conductance regulator (CFTR) was induced in Sprague Dawley rats (Ntac:SD), resulting in loss of protein expression.
ASSOCIATED WITH abnormal chloride level; abnormal circulating protein level; abnormal epiphyseal plate morphology; ASSOCIATED WITH congenital bilateral absence of vas deferens; cystic fibrosis
Type: allele  of Cftr  
Previously known as: Cftr^[em1Sage]
Is Marker For: Strains:   SD-Cftrem1Sage+/-   SD-Cftrem1Sage-/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. Reduced bone length, growth plate thickness, bone content, and IGF-I as a model for poor growth in the CFTR-deficient rat. Stalvey MS, etal., PLoS One. 2017 Nov 30;12(11):e0188497. doi: 10.1371/journal.pone.0188497. eCollection 2017.
2. Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats. Tuggle KL, etal., PLoS One. 2014 Mar 7;9(3):e91253. doi: 10.1371/journal.pone.0091253. eCollection 2014.

Genomics


Related Rat Strains
The following Strains have been annotated to Cftrem1Sage


Expression


Sequence

Nucleotide Sequences


Additional Information