Slc6a4<sup>m1Hubr</sup> (solute carrier family 6 member 4; ZFN induced mutant1, Hubr) - Rat Genome Database

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Gene: Slc6a4m1Hubr (solute carrier family 6 member 4; ZFN induced mutant1, Hubr) Rattus norvegicus
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Symbol: Slc6a4m1Hubr
Name: solute carrier family 6 member 4; ZFN induced mutant1, Hubr
RGD ID: 14390068
Description: An ENU-induced C to A transversion at position 3924 (relative to the start codon in ENSRNOG0000003476) in the slc6a4 gene, resulting in a premature stop codon (TGC>TGA) in the third exon encoding the second extracellular loop and thereby most likely resulting in a non-functional protein product.
ASSOCIATED WITH abnormal acquisiton of operant behavior for a cocaine reinforcer; abnormal cocaine self-administration; anhedonia; ASSOCIATED WITH anxiety disorder; depressive disorder
Type: allele  of Slc6a4  
Previously known as: Slc6a4^[m1Hubr]
Is Marker For: Strains:   WI-Slc6a4m1Hubr-/-   WI-Slc6a4m1Hubr+/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. Increased cocaine self-administration in rats lacking the serotonin transporter: a role for glutamatergic signaling in the habenula. Caffino L, etal., Addict Biol. 2019 Nov;24(6):1167-1178. doi: 10.1111/adb.12673. Epub 2018 Aug 24.
2. Characterization of the serotonin transporter knockout rat: A selective change in the functioning of the serotonergic system. Homberg JR, etal., Neuroscience. 2007 Apr 27;.
3. Adaptations in pre- and postsynaptic 5-HT1A receptor function and cocaine supersensitivity in serotonin transporter knockout rats. Homberg JR, etal., Psychopharmacology (Berl). 2008 Oct;200(3):367-80. Epub 2008 Jun 27.
4. A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders. Olivier JD, etal., Neuroscience. 2008 Mar 27;152(3):573-84. Epub 2008 Jan 1.

Genomics


Related Rat Strains
The following Strains have been annotated to Slc6a4m1Hubr
WI-Slc6a4m1Hubr+/-     WI-Slc6a4m1Hubr-/-    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-18 Slc6a4m1Hubr  solute carrier family 6 member 4; ZFN induced mutant1, Hubr  Slc6a4m1Hubr    Name changed 629549 APPROVED