GPX1 (glutathione peroxidase 1) - Rat Genome Database

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Gene: GPX1 (glutathione peroxidase 1) Sus scrofa
Analyze
Symbol: GPX1
Name: glutathione peroxidase 1
RGD ID: 14277298
Description: ENCODES a protein that exhibits glutathione peroxidase activity (ortholog); phospholipid-hydroperoxide glutathione peroxidase activity (ortholog); INVOLVED IN angiogenesis involved in wound healing (ortholog); apoptotic process (ortholog); arachidonate metabolic process (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Coronary Syndrome (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH 3-methyladenine; bisphenol A; cadmium atom
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cellular glutathione peroxidase; cytosolic glutathione peroxidase; GPx-1; GSHPx-1; phospholipid-hydroperoxide glutathione peroxidase GPX1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,916,246 - 31,917,433 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,916,269 - 31,917,337 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,147,277 - 35,148,345 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Coronary Syndrome  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
Aicardi-Goutieres Syndrome 1  (ISO)
alpha thalassemia  (ISO)
anemia  (ISO)
Anorexia  (ISO)
arteriosclerosis  (ISO)
autistic disorder  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2P  (ISO)
Binge Drinking  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Cadmium Poisoning  (ISO)
calcinosis  (ISO)
Carbon Tetrachloride Poisoning  (ISO)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
carnitine-acylcarnitine translocase deficiency  (ISO)
carotid stenosis  (ISO)
cataract  (ISO)
Chronic Hepatitis  (ISO)
chronic kidney disease  (ISO)
chronic myeloid leukemia  (ISO)
colon cancer  (ISO)
colorectal cancer  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
depressive disorder  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
epilepsy  (ISO)
Experimental Diabetes Mellitus  (ISO)
gastric adenocarcinoma  (ISO)
Genetic Predisposition to Disease  (ISO)
gestational diabetes  (ISO)
Glutathione Peroxidase Deficiency, Hemolytic Anemia possibly due to  (ISO)
glycine encephalopathy  (ISO)
hairy cell leukemia  (ISO)
Head and Neck Neoplasms  (ISO)
Hemolysis  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
hyperhomocysteinemia  (ISO)
hyperinsulinism  (ISO)
hypertension  (ISO)
Hyperthermia  (ISO)
hyperthyroidism  (ISO)
hypothyroidism  (ISO)
iron deficiency anemia  (ISO)
Iron Overload  (ISO)
Keshan disease  (ISO)
laryngeal squamous cell carcinoma  (ISO)
larynx cancer  (ISO)
leukemia  (ISO)
Liver Injury  (ISO)
Liver Neoplasms  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Mercury Poisoning  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
multiple myeloma  (ISO)
myeloid neoplasm  (ISO)
myocardial infarction  (ISO)
nasopharynx carcinoma  (ISO)
nephrosis  (ISO)
nephrotic syndrome  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (ISO)
oral squamous cell carcinoma  (ISO)
osteoporosis  (ISO)
Pierson syndrome  (ISO)
pre-eclampsia  (ISO)
pseudoxanthoma elasticum  (ISO)
Reperfusion Injury  (ISO)
Reticulocytosis  (ISO)
senile cataract  (ISO)
sickle cell anemia  (ISO)
skin melanoma  (ISO)
squamous cell carcinoma  (ISO)
steatotic liver disease  (ISO)
stomach cancer  (ISO)
stomach carcinoma  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
vascular dementia  (ISO)
Venous Thrombosis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis involved in wound healing  (IEA,ISO)
apoptotic process  (IEA,ISO)
arachidonate metabolic process  (IEA,ISS)
biological process involved in interaction with symbiont  (IEA,ISO)
blood vessel endothelial cell migration  (IEA,ISO)
cell redox homeostasis  (IEA)
cellular oxidant detoxification  (IEA)
cellular response to glucose stimulus  (ISO)
endothelial cell development  (IEA,ISO)
epigenetic regulation of gene expression  (IEA)
fat cell differentiation  (IEA,ISO)
fibroblast proliferation  (IEA,ISO)
glutathione metabolic process  (IBA,IEA)
heart contraction  (IEA,ISO)
hydrogen peroxide catabolic process  (IBA,IEA,ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (IEA,ISO)
lipid metabolic process  (IEA,ISO)
lipoxygenase pathway  (IEA,ISS)
myoblast differentiation  (IEA,ISO)
myoblast proliferation  (IEA,ISO)
myotube differentiation  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA)
negative regulation of inflammatory response to antigenic stimulus  (IEA,ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of release of cytochrome c from mitochondria  (IEA)
neuron apoptotic process  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
protein oxidation  (ISO)
regulation of mammary gland epithelial cell proliferation  (IEA)
regulation of proteasomal protein catabolic process  (IEA)
response to estradiol  (ISO)
response to folic acid  (ISO)
response to gamma radiation  (IEA,ISO)
response to glucose  (ISO)
response to hormone  (ISO)
response to hydrogen peroxide  (IBA,IEA,ISO)
response to hydroperoxide  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to nicotine  (ISO)
response to oxidative stress  (IEA,ISO)
response to reactive oxygen species  (IEA,ISO)
response to selenium ion  (IBA,IEA,ISO)
response to symbiotic bacterium  (IEA,ISO)
response to toxic substance  (IEA,ISO)
response to vitamin E  (ISO)
response to wounding  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)
sensory perception of sound  (IEA,ISO)
skeletal muscle fiber development  (IEA,ISO)
skeletal muscle tissue regeneration  (IEA,ISO)
temperature homeostasis  (IEA,ISO)
triglyceride metabolic process  (IEA,ISO)
UV protection  (IEA)
vasodilation  (IEA,ISO)

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IEA,ISS)
Lewy body  (IEA)
mitochondrion  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:16908641   PMID:22301074   PMID:22580339   PMID:30032202  


Genomics

Comparative Map Data
GPX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,916,246 - 31,917,433 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,916,269 - 31,917,337 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,147,277 - 35,148,345 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,357,176 - 49,358,353 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl349,357,174 - 49,358,605 (-)EnsemblGRCh38hg38GRCh38
GRCh37349,394,609 - 49,395,786 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,369,613 - 49,370,795 (-)NCBINCBI36Build 36hg18NCBI36
Build 34349,369,614 - 49,370,795NCBI
Celera349,359,484 - 49,360,663 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef349,454,091 - 49,455,270 (-)NCBIHuRef
CHM1_1349,347,422 - 49,348,601 (-)NCBICHM1_1
T2T-CHM13v2.0349,386,555 - 49,387,726 (-)NCBIT2T-CHM13v2.0
Gpx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,216,279 - 108,217,541 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,216,102 - 108,217,542 (+)EnsemblGRCm39 Ensembl
GRCm389108,339,080 - 108,340,342 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,338,903 - 108,340,343 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,241,607 - 108,242,671 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369108,197,368 - 108,198,432 (+)NCBIMGSCv36mm8
Celera9107,948,378 - 107,949,442 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.24NCBI
Gpx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,905,462 - 117,906,588 (+)NCBIGRCr8
mRatBN7.28109,026,905 - 109,028,031 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,026,905 - 109,028,024 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,654,127 - 114,655,253 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,853,454 - 112,854,580 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,696,094 - 110,697,220 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,117,430 - 117,118,528 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,117,430 - 117,118,522 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,466,118 - 116,467,216 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,329,847 - 108,330,945 (+)ENTREZGENECelera
Cytogenetic Map8q32NCBI
Gpx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555321,298,336 - 1,298,830 (-)NCBIChiLan1.0ChiLan1.0
GPX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2249,334,513 - 49,336,253 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1349,339,284 - 49,340,757 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0349,280,038 - 49,281,455 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,360,736 - 50,362,274 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,360,947 - 50,361,826 (-)Ensemblpanpan1.1panPan2
GPX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,889,165 - 39,890,253 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,889,174 - 39,890,260 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,807,516 - 39,808,604 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02040,245,494 - 40,246,582 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2040,245,503 - 40,246,589 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12039,612,973 - 39,614,061 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,016,432 - 40,017,520 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02040,296,220 - 40,297,308 (+)NCBIUU_Cfam_GSD_1.0
Gpx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,237,446 - 64,238,592 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936529998,150 - 998,987 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936529997,943 - 999,123 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,754,976 - 10,756,617 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041156,259,200 - 156,261,033 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247303,313,972 - 3,314,626 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247303,313,773 - 3,314,870 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GPX1
29 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000046306   ⟹   ENSSSCP00000042853
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1331,914,932 - 31,917,335 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000091800   ⟹   ENSSSCP00000075808
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1331,916,246 - 31,917,433 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000092981   ⟹   ENSSSCP00000075293
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1331,916,246 - 31,917,335 (-)Ensembl
RefSeq Acc Id: NM_214201   ⟹   NP_999366
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11331,916,269 - 31,917,337 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999366 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAM94630 (Get FASTA)   NCBI Sequence Viewer  
  AAU89708 (Get FASTA)   NCBI Sequence Viewer  
  AID58016 (Get FASTA)   NCBI Sequence Viewer  
  CAA09098 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000075293.1
  ENSSSCP00000075808
  ENSSSCP00000075808.1
GenBank Protein Q8MJ14 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_999366   ⟸   NM_214201
- UniProtKB: Q8MJ14 (UniProtKB/Swiss-Prot),   A0A068F143 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000042853   ⟸   ENSSSCT00000046306
Ensembl Acc Id: ENSSSCP00000075293   ⟸   ENSSSCT00000092981
Ensembl Acc Id: ENSSSCP00000075808   ⟸   ENSSSCT00000091800


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000033727 Ensembl
  ENSSSCG00000060656 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000091800 ENTREZGENE
  ENSSSCT00000091800.1 UniProtKB/TrEMBL
  ENSSSCT00000092981.1 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Glutathione_peroxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPX_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPX_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397403 UniProtKB/Swiss-Prot
NCBI Gene GPX1 ENTREZGENE
PANTHER GLUTATHIONE PEROXIDASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11592 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GSHPx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Glutathion_perox UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GLUTPROXDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLUTATHIONE_PEROXID_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE_PEROXID_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE_PEROXID_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A068F143 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SUH2_PIG UniProtKB/TrEMBL
  A0A8W4F7K8_PIG UniProtKB/TrEMBL
  GPX1_PIG UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A8W4F8U8 UniProtKB/TrEMBL
VGNC ID VGNC:88652 ENTREZGENE