DUOX2 (dual oxidase 2) - Rat Genome Database

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Gene: DUOX2 (dual oxidase 2) Sus scrofa
Analyze
Symbol: DUOX2
Name: dual oxidase 2
RGD ID: 14268729
Description: ENCODES a protein that exhibits calcium ion binding (inferred); heme binding (inferred); metal ion binding (inferred); INVOLVED IN cuticle development (ortholog); cytokine-mediated signaling pathway (ortholog); hydrogen peroxide biosynthetic process (ortholog); PARTICIPATES IN thyroid hormone biosynthetic pathway; ASSOCIATED WITH AGAT deficiency (ortholog); Bloom syndrome (ortholog); cholera (ortholog); FOUND IN apical part of cell (ortholog); cell leading edge (ortholog); cell surface (ortholog); INTERACTS WITH 3',5'-cyclic AMP; ammonia; copper(II) sulfate
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: NADH/NADPH thyroid oxidase p138-tox
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1126,620,510 - 126,641,406 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11126,620,468 - 126,641,406 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21141,221,502 - 141,241,329 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:10601291   PMID:12538618   PMID:12639906   PMID:14681463   PMID:15150274   PMID:15591162   PMID:15972824   PMID:17145712   PMID:22301074   PMID:28972010   PMID:30032202  


Genomics

Comparative Map Data
DUOX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1126,620,510 - 126,641,406 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11126,620,468 - 126,641,406 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21141,221,502 - 141,241,329 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DUOX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381545,092,650 - 45,114,172 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1545,092,650 - 45,114,172 (-)EnsemblGRCh38hg38GRCh38
GRCh371545,384,848 - 45,406,370 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361543,172,144 - 43,193,651 (-)NCBINCBI36Build 36hg18NCBI36
Build 341543,172,144 - 43,193,651NCBI
Celera1522,276,281 - 22,297,794 (-)NCBICelera
Cytogenetic Map15q21.1NCBI
HuRef1522,209,058 - 22,230,571 (-)NCBIHuRef
CHM1_11545,503,163 - 45,524,692 (-)NCBICHM1_1
T2T-CHM13v2.01542,900,666 - 42,922,193 (-)NCBIT2T-CHM13v2.0
Duox2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392122,109,727 - 122,129,221 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2122,109,728 - 122,128,930 (-)EnsemblGRCm39 Ensembl
GRCm382122,279,246 - 122,298,740 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2122,279,247 - 122,298,449 (-)EnsemblGRCm38mm10GRCm38
MGSCv372122,106,173 - 122,123,901 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362121,971,878 - 121,989,606 (-)NCBIMGSCv36mm8
Celera2123,430,543 - 123,448,297 (-)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.61NCBI
Duox2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83129,680,543 - 129,698,886 (-)NCBIGRCr8
mRatBN7.23109,223,809 - 109,247,023 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3109,226,924 - 109,245,902 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3112,900,635 - 112,918,867 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03121,496,154 - 121,514,388 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03119,156,528 - 119,174,762 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03114,218,187 - 114,237,808 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3114,218,193 - 114,235,933 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03120,757,633 - 120,776,304 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43109,059,360 - 109,077,106 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13108,964,932 - 108,982,679 (-)NCBI
Celera3108,124,745 - 108,142,508 (-)NCBICelera
Cytogenetic Map3q35NCBI
Duox2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554098,271,164 - 8,287,096 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554098,270,657 - 8,288,201 (+)NCBIChiLan1.0ChiLan1.0
DUOX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21634,333,405 - 34,353,780 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11538,511,302 - 38,531,933 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01524,040,513 - 24,061,758 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11542,393,643 - 42,414,281 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1542,395,135 - 42,414,281 (-)Ensemblpanpan1.1panPan2
DUOX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13011,521,833 - 11,541,719 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3011,521,845 - 11,541,716 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3011,578,140 - 11,598,867 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03011,658,603 - 11,679,500 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3011,658,612 - 11,678,512 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13011,564,842 - 11,585,734 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03011,687,574 - 11,708,297 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03011,806,853 - 11,827,575 (-)NCBIUU_Cfam_GSD_1.0
Duox2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864089,964,100 - 89,983,254 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364717,813,128 - 7,831,258 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364717,812,163 - 7,831,258 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUOX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12638,090,053 - 38,110,781 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2638,090,648 - 38,109,636 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048102,947,646 - 102,968,937 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Duox2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473114,122,608 - 14,138,121 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473114,121,855 - 14,139,344 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DUOX2
465 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 9 2 5 14 12 9 3 3 3

Sequence


Ensembl Acc Id: ENSSSCT00000005164   ⟹   ENSSSCP00000005038
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1126,620,510 - 126,641,406 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000038251   ⟹   ENSSSCP00000057672
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1126,620,477 - 126,641,419 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000046180   ⟹   ENSSSCP00000049869
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1126,620,510 - 126,641,406 (+)Ensembl
RefSeq Acc Id: NM_213999   ⟹   NP_999164
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11126,620,510 - 126,641,406 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021082558   ⟹   XP_020938217
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11126,620,468 - 126,641,405 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999164 (Get FASTA)   NCBI Sequence Viewer  
  XP_020938217 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF20056 (Get FASTA)   NCBI Sequence Viewer  
  AAN39339 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000049869
GenBank Protein Q8HZK2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_020938217   ⟸   XM_021082558
- Peptide Label: isoform X1
- UniProtKB: A0A287B129 (UniProtKB/TrEMBL),   A0A8D0SD24 (UniProtKB/TrEMBL),   A0A8D0ZFJ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_999164   ⟸   NM_213999
- Peptide Label: precursor
- UniProtKB: Q9TT98 (UniProtKB/Swiss-Prot),   Q8HZK2 (UniProtKB/Swiss-Prot),   A0A4X1VGQ6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000005038   ⟸   ENSSSCT00000005164
Ensembl Acc Id: ENSSSCP00000049869   ⟸   ENSSSCT00000046180
Ensembl Acc Id: ENSSSCP00000057672   ⟸   ENSSSCT00000038251

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004678 Ensembl, ENTREZGENE
Ensembl Transcript ENSSSCT00000046180 ENTREZGENE
Gene3D-CATH 1.10.640.10 UniProtKB/Swiss-Prot
  3.40.50.80 UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
  Translation factors UniProtKB/Swiss-Prot
InterPro DUOX_peroxidase UniProtKB/Swiss-Prot
  EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
  FAD-bd_8 UniProtKB/Swiss-Prot
  FAD-bd_FR_type UniProtKB/Swiss-Prot
  Fe3_Rdtase_TM_dom UniProtKB/Swiss-Prot
  Fe_red_NAD-bd_6 UniProtKB/Swiss-Prot
  FNR_nucleotide-bd UniProtKB/Swiss-Prot
  Haem_peroxidase_animal UniProtKB/Swiss-Prot
  Haem_peroxidase_sf UniProtKB/Swiss-Prot
  Haem_peroxidase_sf_animal UniProtKB/Swiss-Prot
  RBOH/FRE UniProtKB/Swiss-Prot
  Riboflavin_synthase-like_b-brl UniProtKB/Swiss-Prot
KEGG Report ssc:397060 UniProtKB/Swiss-Prot
NCBI Gene DUOX2 ENTREZGENE
PANTHER NADPH OXIDASE UniProtKB/Swiss-Prot
  PTHR11972:SF67 UniProtKB/Swiss-Prot
Pfam An_peroxidase UniProtKB/Swiss-Prot
  EF-hand_1 UniProtKB/Swiss-Prot
  EF-hand_8 UniProtKB/Swiss-Prot
  FAD_binding_8 UniProtKB/Swiss-Prot
  Ferric_reduct UniProtKB/Swiss-Prot
  NAD_binding_6 UniProtKB/Swiss-Prot
PRINTS ANPEROXIDASE UniProtKB/Swiss-Prot
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
  FAD_FR UniProtKB/Swiss-Prot
  PEROXIDASE_3 UniProtKB/Swiss-Prot
SMART EFh UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot
  SSF48113 UniProtKB/Swiss-Prot
  SSF52343 UniProtKB/Swiss-Prot
  SSF63380 UniProtKB/Swiss-Prot
UniProt A0A287B129 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VE59_PIG UniProtKB/TrEMBL
  A0A4X1VGQ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0SD24 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0ZFJ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1CSR9_PIG UniProtKB/TrEMBL
  A0A8D1GBH2_PIG UniProtKB/TrEMBL
  A0A8D1KPL5_PIG UniProtKB/TrEMBL
  A0A8D1VFS3_PIG UniProtKB/TrEMBL
  DUOX2_PIG UniProtKB/Swiss-Prot
  F1SN39_PIG UniProtKB/TrEMBL
  Q8HZK2 ENTREZGENE
  Q9TT98 ENTREZGENE
UniProt Secondary Q9TT98 UniProtKB/Swiss-Prot
VGNC ID VGNC:103086 ENTREZGENE