CXCL8 (C-X-C motif chemokine ligand 8) - Rat Genome Database

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Gene: CXCL8 (C-X-C motif chemokine ligand 8) Sus scrofa
Analyze
Symbol: CXCL8
Name: C-X-C motif chemokine ligand 8
RGD ID: 14244462
Description: ENCODES a protein that exhibits heparin binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide; cellular response to virus; chemotaxis (ortholog); PARTICIPATES IN chemokine (C-X-C motif) ligand 8 signaling pathway; mTOR signaling pathway; syndecan signaling pathway; ASSOCIATED WITH acute asthma (ortholog); Acute Lung Injury (ortholog); acute pyelonephritis (ortholog); FOUND IN extracellular region; INTERACTS WITH 3',4',5'-Trimethoxyflavone; anthra[1,9-cd]pyrazol-6(2H)-one; apigenin
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alveolar macrophage chemotactic factor I; alveolar macrophage-derived chemotactic factor-I; AMCF-I; C-X-C motif chemokine 8; chemokine (C-X-C motif) ligand 8; IL-8; IL8; interleukin-8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl869,932,643 - 69,935,861 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1869,932,646 - 69,935,861 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2874,083,530 - 74,086,749 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute asthma  (ISO)
Acute Lung Injury  (ISO)
acute pyelonephritis  (ISO)
Acute-On-Chronic Liver Failure  (ISO)
adenocarcinoma  (ISO)
adult respiratory distress syndrome  (ISO)
alcoholic hepatitis  (ISO)
allergic disease  (ISO)
Anorexia  (ISO)
autoimmune uveitis  (ISO)
Bacterial Eye Infections  (ISO)
bacterial gastritis  (ISO)
Bacterial Lung Diseases  (ISO)
Barrett's esophagus  (ISO)
Behcet's disease  (ISO)
biliary atresia  (ISO)
Breast Neoplasms  (ISO)
brucellosis  (ISO)
bullous pemphigoid  (ISO)
Cachexia  (ISO)
Cardiotoxicity  (ISO)
Chagas Cardiomyopathy  (ISO)
chikungunya  (ISO)
cholangiocarcinoma  (ISO)
cholestasis  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (ISO)
Colorectal Neoplasms  (ISO)
common cold  (ISO)
congestive heart failure  (ISO)
COVID-19  (ISO)
cryptococcosis  (ISO)
cutaneous leishmaniasis  (ISO)
cystic fibrosis  (ISO)
Down syndrome  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Edema  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
Enterovirus Infections  (ISO)
esophagus squamous cell carcinoma  (ISO)
eumycotic mycetoma  (ISO)
Experimental Colitis  (ISO)
extrapulmonary tuberculosis  (ISO)
Fever  (ISO)
gastritis  (ISO)
gastroesophageal reflux disease  (ISO)
glioblastoma  (ISO)
glomerulonephritis  (ISO)
head and neck cancer  (ISO)
Helicobacter Infections  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperalgesia  (ISO)
Inflammation  (ISO)
Inflammatory Breast Neoplasms  (ISO)
intermediate coronary syndrome  (ISO)
Intractable Pain  (ISO)
intrahepatic cholestasis  (ISO)
keratitis  (ISO)
Klebsiella pneumonia  (ISO)
leprosy  (ISO)
lichen disease  (ISO)
liver cirrhosis  (ISO)
Liver Failure  (ISO)
Liver Metastasis  (ISO)
lung non-small cell carcinoma  (ISO)
Lyme Neuroborreliosis  (ISO)
malignant mesothelioma  (ISO)
multiple sclerosis  (ISO)
Mycobacterium avium complex disease  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplastic Cell Transformation  (ISO)
Neurosyphilis  (ISO)
nicotine dependence  (ISO)
oral cavity cancer  (ISO)
oral submucous fibrosis  (ISO)
oropharynx cancer  (ISO)
otitis media  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
peptic esophagitis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
Postherpetic Neuralgia  (ISO)
primary biliary cholangitis  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Infections  (ISO)
psoriatic arthritis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
Reperfusion Injury  (ISO)
respiratory syncytial virus infectious disease  (ISO)
rheumatoid arthritis  (ISO)
Salmonella Infections, Animal  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Spine Osteoarthritis  (ISO)
squamous cell carcinoma  (ISO)
Staphylococcal Infections  (ISO)
steatotic liver disease  (ISO)
stomach carcinoma  (ISO)
Stomach Neoplasms  (ISO)
Thyroid Neoplasms  (ISO)
tongue squamous cell carcinoma  (ISO)
tonsil cancer  (ISO)
Toxoplasma Chorioretinitis  (ISO)
trachoma  (ISO)
Triple Negative Breast Neoplasms  (ISO)
tropical spastic paraparesis  (ISO)
trypanosomiasis  (ISO)
tuberculosis  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
urinary tract infection  (ISO)
viral encephalitis  (ISO)
viral pneumonia  (ISO)
visceral leishmaniasis  (ISO)
vulvovaginal candidiasis  (ISO)
Wilson disease  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Immuno-modulating properties of Tulathromycin in porcine monocyte-derived macrophages infected with porcine reproductive and respiratory syndrome virus. Desmonts de Lamache D, etal., PLoS One. 2019 Aug 23;14(8):e0221560. doi: 10.1371/journal.pone.0221560. eCollection 2019.
Additional References at PubMed
PMID:1420165   PMID:1850745   PMID:8276881   PMID:12464027   PMID:14681463   PMID:15528384   PMID:15912099   PMID:17145712   PMID:19232500   PMID:21314908   PMID:21318239   PMID:22301074  
PMID:23102097   PMID:23751822   PMID:23879680   PMID:24792438   PMID:25147235   PMID:25575706   PMID:26581603   PMID:28347884   PMID:29521102   PMID:30032202   PMID:31831027   PMID:34935443  
PMID:38675986   PMID:38791369  


Genomics

Comparative Map Data
CXCL8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl869,932,643 - 69,935,861 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1869,932,646 - 69,935,861 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2874,083,530 - 74,086,749 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CXCL8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38473,740,569 - 73,743,716 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl473,740,519 - 73,743,716 (+)EnsemblGRCh38hg38GRCh38
GRCh37474,606,286 - 74,609,433 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36474,825,139 - 74,828,297 (+)NCBINCBI36Build 36hg18NCBI36
Build 34474,971,309 - 74,974,466NCBI
Celera471,966,137 - 71,969,295 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,417,707 - 70,420,917 (+)NCBIHuRef
CHM1_1474,642,243 - 74,645,454 (+)NCBICHM1_1
T2T-CHM13v2.0477,084,334 - 77,087,480 (+)NCBIT2T-CHM13v2.0
Cxcl15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39590,942,393 - 90,950,926 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl590,942,393 - 90,950,926 (+)EnsemblGRCm39 Ensembl
GRCm38590,794,534 - 90,803,067 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,794,534 - 90,803,067 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,223,560 - 91,232,093 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36591,869,771 - 91,877,088 (+)NCBIMGSCv36mm8
Celera588,946,158 - 88,954,669 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
Cxcl8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955474241,501 - 250,643 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955474247,326 - 250,355 (+)NCBIChiLan1.0ChiLan1.0
CXCL8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2356,320,800 - 56,323,963 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1456,509,875 - 56,513,034 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0450,452,857 - 50,456,015 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1456,285,026 - 56,288,308 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl456,286,708 - 56,288,083 (-)Ensemblpanpan1.1panPan2
CXCL8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11362,435,035 - 62,438,354 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1362,434,422 - 62,438,354 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1362,104,414 - 62,107,728 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01363,245,400 - 63,248,688 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1363,244,998 - 63,248,244 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11362,855,624 - 62,858,940 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01362,345,249 - 62,348,566 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01363,485,538 - 63,488,849 (+)NCBIUU_Cfam_GSD_1.0
LOC101964975
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528513,326,322 - 13,329,490 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365981,779,471 - 1,781,353 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365981,779,471 - 1,781,353 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CXCL8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1722,202,497 - 22,205,730 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl722,202,527 - 22,204,068 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666084587,605 - 589,481 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cxcl8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247301,743,916 - 1,747,293 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247301,744,097 - 1,747,206 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CXCL8
51 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 4 2 5 13 11 4 2 2 3

Sequence


Ensembl Acc Id: ENSSSCT00000009807   ⟹   ENSSSCP00000009554
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl869,932,644 - 69,935,860 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000068386   ⟹   ENSSSCP00000061888
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl869,932,643 - 69,935,861 (+)Ensembl
RefSeq Acc Id: NM_213867   ⟹   NP_999032
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1869,932,646 - 69,935,861 (+)NCBI
Sequence:
RefSeq Acc Id: NP_999032   ⟸   NM_213867
- Peptide Label: precursor
- UniProtKB: P22951 (UniProtKB/Swiss-Prot),   P26894 (UniProtKB/Swiss-Prot),   Q68CM2 (UniProtKB/TrEMBL),   G8EGP8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000009554   ⟸   ENSSSCT00000009807
Ensembl Acc Id: ENSSSCP00000061888   ⟸   ENSSSCT00000068386

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000008953 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00005040921 UniProtKB/Swiss-Prot
  ENSSSCG00015028695 UniProtKB/TrEMBL
  ENSSSCG00025017428 UniProtKB/Swiss-Prot
  ENSSSCG00030036565 UniProtKB/Swiss-Prot
  ENSSSCG00035071462 UniProtKB/Swiss-Prot
  ENSSSCG00040074984 UniProtKB/Swiss-Prot
  ENSSSCG00045009964 UniProtKB/Swiss-Prot
  ENSSSCG00050007526 UniProtKB/TrEMBL
  ENSSSCG00055030636 UniProtKB/Swiss-Prot
  ENSSSCG00060039839 UniProtKB/Swiss-Prot
  ENSSSCG00065014250 UniProtKB/TrEMBL
  ENSSSCG00070006372 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000009807 ENTREZGENE
  ENSSSCT00000009807.5 UniProtKB/Swiss-Prot
  ENSSSCT00000068386.1 UniProtKB/TrEMBL
  ENSSSCT00005065575 UniProtKB/Swiss-Prot
  ENSSSCT00015038033.1 UniProtKB/TrEMBL
  ENSSSCT00025023573.1 UniProtKB/Swiss-Prot
  ENSSSCT00030050860.1 UniProtKB/Swiss-Prot
  ENSSSCT00035096660.1 UniProtKB/Swiss-Prot
  ENSSSCT00040103852.1 UniProtKB/Swiss-Prot
  ENSSSCT00045016902.1 UniProtKB/Swiss-Prot
  ENSSSCT00050010273.1 UniProtKB/TrEMBL
  ENSSSCT00055061067.1 UniProtKB/Swiss-Prot
  ENSSSCT00060053953.1 UniProtKB/Swiss-Prot
  ENSSSCT00065018957.1 UniProtKB/TrEMBL
  ENSSSCT00070012189.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CXC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CXC_Chemokine_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396880 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene CXCL8 ENTREZGENE
PANTHER INTERLEUKIN-8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMALL INDUCIBLE CYTOKINE A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS INTERLEUKIN8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMALLCYTKCXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SMALL_CYTOKINES_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SCY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5G2QBL8_PIG UniProtKB/TrEMBL
  A0A8D0N8L1_PIG UniProtKB/TrEMBL
  G8EGP8 ENTREZGENE, UniProtKB/TrEMBL
  IL8_PIG UniProtKB/Swiss-Prot
  P22951 ENTREZGENE
  P26894 ENTREZGENE
  Q68CM2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P22951 UniProtKB/Swiss-Prot
VGNC ID VGNC:87106 ENTREZGENE