AKR1C1 (aldo-keto reductase family 1, member C1) - Rat Genome Database

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Gene: AKR1C1 (aldo-keto reductase family 1, member C1) Sus scrofa
Analyze
Symbol: AKR1C1 (Ensembl: AKR1C2)
Name: aldo-keto reductase family 1, member C1
RGD ID: 14236396
Description: ENCODES a protein that exhibits 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity (ortholog); aldo-keto reductase (NADPH) activity (ortholog); aldose reductase (NADPH) activity (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); cellular response to corticosteroid stimulus (ortholog); cellular response to jasmonic acid stimulus (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); B-lymphoblastic leukemia/lymphoma (ortholog); castration-resistant prostate carcinoma (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH deoxynivalenol; zearalenone
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: aldo-keto reductase family 1 C1; aldo-keto reductase family 1 member C1; aldo-keto reductase family 1 member C1-like; putative aldo-keto reductase family 1 member C1
RGD Orthologs
Human
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1065,576,464 - 65,678,248 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11065,580,297 - 65,594,998 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21071,833,237 - 71,847,948 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
nucleus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:30032202   PMID:32370225  


Genomics

Comparative Map Data
AKR1C1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1065,576,464 - 65,678,248 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11065,580,297 - 65,594,998 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21071,833,237 - 71,847,948 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AKR1C3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38105,048,781 - 5,107,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl105,035,354 - 5,107,686 (+)EnsemblGRCh38hg38GRCh38
GRCh37105,090,973 - 5,149,878 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,126,568 - 5,139,878 (+)NCBINCBI36Build 36hg18NCBI36
Build 34105,126,567 - 5,139,878NCBI
Celera105,076,549 - 5,089,836 (+)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef105,024,814 - 5,083,613 (+)NCBIHuRef
CHM1_1105,091,312 - 5,150,193 (+)NCBICHM1_1
T2T-CHM13v2.0105,049,294 - 5,108,188 (+)NCBIT2T-CHM13v2.0
AKR1C3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2817,590,820 - 17,668,960 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11017,660,905 - 17,732,534 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0105,079,580 - 5,157,572 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1105,061,119 - 5,139,818 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl105,081,214 - 5,139,812 (+)Ensemblpanpan1.1panPan2

Variants

.
Variants in AKR1C1
543 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 22 3 2 5 14 12 22 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000012199   ⟹   ENSSSCP00000011886
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1065,578,737 - 65,594,890 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000012200   ⟹   ENSSSCP00000011887
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1065,580,361 - 65,595,000 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000041369   ⟹   ENSSSCP00000049928
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1065,576,464 - 65,594,899 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000068825   ⟹   ENSSSCP00000069909
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1065,580,364 - 65,594,994 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000100057   ⟹   ENSSSCP00000076692
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1065,580,365 - 65,594,999 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000102995   ⟹   ENSSSCP00000076786
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1065,576,464 - 65,592,844 (+)Ensembl
RefSeq Acc Id: NM_001044569   ⟹   NP_001038034
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11065,580,396 - 65,594,998 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013980353   ⟹   XP_013835807
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11065,580,297 - 65,594,941 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021064077   ⟹   XP_020919736
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11065,580,297 - 65,594,941 (+)NCBI
Sequence:
RefSeq Acc Id: XP_013835807   ⟸   XM_013980353
- Peptide Label: isoform X1
- UniProtKB: A0A8D1ZNQ5 (UniProtKB/TrEMBL),   A0A287B0I7 (UniProtKB/TrEMBL),   A0A480YJR0 (UniProtKB/TrEMBL),   A0A480W9N8 (UniProtKB/TrEMBL),   A0A8D0ZP20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020919736   ⟸   XM_021064077
- Peptide Label: isoform X2
- UniProtKB: A0A8D0ZP20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001038034   ⟸   NM_001044569
- UniProtKB: Q1KLB4 (UniProtKB/TrEMBL),   A0A480W9N8 (UniProtKB/TrEMBL),   A0A8D0ZP20 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000049928   ⟸   ENSSSCT00000041369
Ensembl Acc Id: ENSSSCP00000076692   ⟸   ENSSSCT00000100057
Ensembl Acc Id: ENSSSCP00000069909   ⟸   ENSSSCT00000068825
Ensembl Acc Id: ENSSSCP00000011886   ⟸   ENSSSCT00000012199
Ensembl Acc Id: ENSSSCP00000076786   ⟸   ENSSSCT00000102995
Ensembl Acc Id: ENSSSCP00000011887   ⟸   ENSSSCT00000012200
Protein Domains
NADP-dependent oxidoreductase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000011147 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015040227 UniProtKB/TrEMBL
  ENSSSCG00025025024 UniProtKB/TrEMBL
  ENSSSCG00035037179 UniProtKB/TrEMBL
  ENSSSCG00045027247 UniProtKB/TrEMBL
  ENSSSCG00055000821 UniProtKB/TrEMBL
  ENSSSCG00065066501 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000012199.5 UniProtKB/TrEMBL
  ENSSSCT00000012200 ENTREZGENE
  ENSSSCT00000012200.5 UniProtKB/TrEMBL
  ENSSSCT00000041369 ENTREZGENE
  ENSSSCT00000041369.3 UniProtKB/TrEMBL
  ENSSSCT00000068825.2 UniProtKB/TrEMBL
  ENSSSCT00000100057.1 UniProtKB/TrEMBL
  ENSSSCT00000102995.1 UniProtKB/TrEMBL
  ENSSSCT00015053559.1 UniProtKB/TrEMBL
  ENSSSCT00015054653.1 UniProtKB/TrEMBL
  ENSSSCT00015054966.1 UniProtKB/TrEMBL
  ENSSSCT00015055201.1 UniProtKB/TrEMBL
  ENSSSCT00015055451.1 UniProtKB/TrEMBL
  ENSSSCT00015055717.1 UniProtKB/TrEMBL
  ENSSSCT00015055802.1 UniProtKB/TrEMBL
  ENSSSCT00015056271.1 UniProtKB/TrEMBL
  ENSSSCT00025035218.1 UniProtKB/TrEMBL
  ENSSSCT00035049304.1 UniProtKB/TrEMBL
  ENSSSCT00035049310.1 UniProtKB/TrEMBL
  ENSSSCT00035049323.1 UniProtKB/TrEMBL
  ENSSSCT00035049330.1 UniProtKB/TrEMBL
  ENSSSCT00035049335.1 UniProtKB/TrEMBL
  ENSSSCT00035049336.1 UniProtKB/TrEMBL
  ENSSSCT00035049345.1 UniProtKB/TrEMBL
  ENSSSCT00035049361.1 UniProtKB/TrEMBL
  ENSSSCT00035049375.1 UniProtKB/TrEMBL
  ENSSSCT00045046507.1 UniProtKB/TrEMBL
  ENSSSCT00055001486.1 UniProtKB/TrEMBL
  ENSSSCT00055001524.1 UniProtKB/TrEMBL
  ENSSSCT00055001592.1 UniProtKB/TrEMBL
  ENSSSCT00065091298.1 UniProtKB/TrEMBL
  ENSSSCT00065091485.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/TrEMBL
InterPro AKR1C UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/TrEMBL
  Aldo/keto_reductase UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:733634 UniProtKB/TrEMBL
NCBI Gene AKR1C1 ENTREZGENE
PANTHER ALDO-KETO REDUCTASE FAMILY 1 MEMBER C15 UniProtKB/TrEMBL
  ALDO-KETO REDUCTASE FAMILY 1 MEMBER C4 UniProtKB/TrEMBL
  ALDO/KETO REDUCTASE UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/TrEMBL
PIRSF AKR UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_2 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF51430 UniProtKB/TrEMBL
UniProt A0A287B0I7 ENTREZGENE
  A0A480W9N8 ENTREZGENE, UniProtKB/TrEMBL
  A0A480YJR0 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2RFR3_PIG UniProtKB/TrEMBL
  A0A5K1UL95_PIG UniProtKB/TrEMBL
  A0A8D0NNY0_PIG UniProtKB/TrEMBL
  A0A8D0NPP2_PIG UniProtKB/TrEMBL
  A0A8D0NRT1_PIG UniProtKB/TrEMBL
  A0A8D0NUK4_PIG UniProtKB/TrEMBL
  A0A8D0NVQ8_PIG UniProtKB/TrEMBL
  A0A8D0NWS8_PIG UniProtKB/TrEMBL
  A0A8D0U3D5_PIG UniProtKB/TrEMBL
  A0A8D0ZKL1_PIG UniProtKB/TrEMBL
  A0A8D0ZKM2_PIG UniProtKB/TrEMBL
  A0A8D0ZKS5_PIG UniProtKB/TrEMBL
  A0A8D0ZNZ0_PIG UniProtKB/TrEMBL
  A0A8D0ZP20 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0ZS09_PIG UniProtKB/TrEMBL
  A0A8D0ZS19_PIG UniProtKB/TrEMBL
  A0A8D0ZU83_PIG UniProtKB/TrEMBL
  A0A8D0ZUC9_PIG UniProtKB/TrEMBL
  A0A8D1P9W3_PIG UniProtKB/TrEMBL
  A0A8D1PBI7_PIG UniProtKB/TrEMBL
  A0A8D1ZNQ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FBL5_PIG UniProtKB/TrEMBL
  A0A8W4FBQ0_PIG UniProtKB/TrEMBL
  F1RYV5_PIG UniProtKB/TrEMBL
  G5DGE2_PIG UniProtKB/TrEMBL
  Q1KLB4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A287B0I7 UniProtKB/TrEMBL
  F1RYT8 UniProtKB/TrEMBL
  F1RYV6 UniProtKB/TrEMBL