CRH (corticotropin releasing hormone) - Rat Genome Database

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Gene: CRH (corticotropin releasing hormone) Sus scrofa
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Symbol: CRH
Name: corticotropin releasing hormone
RGD ID: 14226532
Description: ENCODES a protein that exhibits corticotropin-releasing hormone receptor 1 binding (ortholog); corticotropin-releasing hormone receptor 2 binding (ortholog); INVOLVED IN adrenal gland development (ortholog); associative learning (ortholog); cellular response to cocaine (ortholog); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alcohol-Related Disorders (ortholog); alopecia (ortholog); FOUND IN extracellular space (ortholog); neuronal cell body (ortholog); neuronal dense core vesicle lumen (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: corticoliberin; corticotropin-releasing factor; CRF
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl468,484,053 - 68,486,121 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1468,481,696 - 68,486,122 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2474,349,511 - 74,653,689 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IEA,ISO)
associative learning  (ISO)
cellular response to cocaine  (ISO)
cellular response to dexamethasone stimulus  (ISO)
diterpenoid metabolic process  (ISO)
female pregnancy  (IEA)
glucocorticoid biosynthetic process  (IEA,ISO)
hormone-mediated apoptotic signaling pathway  (ISO)
hypothalamus development  (ISO)
inflammatory response  (IEA,ISO)
learning or memory  (ISO)
locomotory exploration behavior  (IEA,ISO)
long-term synaptic potentiation  (ISO)
lung development  (IEA,ISO)
monoatomic ion homeostasis  (ISO)
negative regulation of epinephrine secretion  (IBA,ISO)
negative regulation of gene expression  (ISO)
negative regulation of glucagon secretion  (IBA,ISO)
negative regulation of luteinizing hormone secretion  (ISO)
negative regulation of norepinephrine secretion  (ISO)
negative regulation of systemic arterial blood pressure  (ISO)
neuron apoptotic process  (ISO)
positive regulation of behavioral fear response  (ISO)
positive regulation of calcium ion import  (ISO)
positive regulation of cAMP/PKA signal transduction  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular process  (ISO)
positive regulation of corticosterone secretion  (ISO)
positive regulation of corticotropin secretion  (IEA,ISO)
positive regulation of cortisol secretion  (IBA,IEA)
positive regulation of digestive system process  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of protein phosphorylation  (ISO)
regulation of NMDA receptor activity  (ISO)
regulation of serotonin secretion  (ISO)
response to alcohol  (ISO)
response to aldosterone  (ISO)
response to cocaine  (ISO)
response to corticosterone  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to ether  (ISO)
response to immobilization stress  (ISO)
response to pain  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)
steroid metabolic process  (ISO)
synaptic transmission, dopaminergic  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:3878520   PMID:9734873   PMID:12030933   PMID:16483545   PMID:20431270   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CRH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl468,484,053 - 68,486,121 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1468,481,696 - 68,486,122 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2474,349,511 - 74,653,689 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38866,176,376 - 66,178,464 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl866,176,376 - 66,178,464 (-)EnsemblGRCh38hg38GRCh38
GRCh37867,088,611 - 67,090,699 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36867,251,173 - 67,253,252 (-)NCBINCBI36Build 36hg18NCBI36
Build 34867,251,172 - 67,253,252NCBI
Celera863,080,325 - 63,082,559 (-)NCBICelera
Cytogenetic Map8q13.1NCBI
HuRef862,578,767 - 62,581,001 (-)NCBIHuRef
CHM1_1867,143,265 - 67,145,499 (-)NCBICHM1_1
T2T-CHM13v2.0866,602,063 - 66,612,357 (-)NCBIT2T-CHM13v2.0
Crh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39319,747,565 - 19,749,560 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl319,747,565 - 19,749,560 (-)EnsemblGRCm39 Ensembl
GRCm38319,693,401 - 19,695,396 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl319,693,401 - 19,695,396 (-)EnsemblGRCm38mm10GRCm38
MGSCv37319,593,401 - 19,595,396 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36319,885,565 - 19,887,480 (-)NCBIMGSCv36mm8
Celera319,686,501 - 19,688,496 (-)NCBICelera
Cytogenetic Map3A2NCBI
cM Map35.75NCBI
Crh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82104,059,184 - 104,061,048 (-)NCBIGRCr8
mRatBN7.22102,143,055 - 102,144,919 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2102,143,055 - 102,144,919 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2108,674,139 - 108,676,025 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02106,795,271 - 106,797,157 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02101,764,428 - 101,766,314 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02104,459,999 - 104,461,863 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2104,459,999 - 104,461,863 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02124,182,919 - 124,184,783 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42104,764,023 - 104,765,887 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12104,708,984 - 104,710,849 (-)NCBI
Celera297,536,796 - 97,538,660 (-)NCBICelera
Cytogenetic Map2q24NCBI
Crh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544412,989,210 - 12,991,300 (+)NCBIChiLan1.0ChiLan1.0
CRH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2781,908,836 - 81,919,149 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1857,548,461 - 57,558,776 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0862,714,721 - 62,716,979 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1864,382,912 - 64,385,175 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl864,383,419 - 64,384,009 (-)Ensemblpanpan1.1panPan2
CRH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12915,831,944 - 15,840,560 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2915,831,944 - 15,834,384 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2916,146,733 - 16,149,174 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02915,890,845 - 16,097,836 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2915,910,573 - 15,913,018 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12915,940,159 - 15,942,599 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02916,042,480 - 16,044,918 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02916,298,228 - 16,300,672 (-)NCBIUU_Cfam_GSD_1.0
Crh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530367,023,855 - 67,026,364 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364967,760,532 - 7,761,122 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364967,759,656 - 7,761,555 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1862,052,155 - 62,056,424 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl862,052,592 - 62,053,182 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603979,456,894 - 79,459,404 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474425,194,495 - 25,196,488 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474425,194,458 - 25,196,658 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CRH
81 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
mesenchyme
mesoderm
nervous system
1 2 16 4 4 16

Sequence


Ensembl Acc Id: ENSSSCT00000006811   ⟹   ENSSSCP00000006626
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl468,484,053 - 68,486,121 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000090438   ⟹   ENSSSCP00000067099
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl468,484,052 - 68,486,114 (+)Ensembl
RefSeq Acc Id: NM_001113062   ⟹   NP_001106533
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1468,484,054 - 68,486,122 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021088452   ⟹   XP_020944111
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1468,481,696 - 68,486,122 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020944111   ⟸   XM_021088452
- Peptide Label: isoform X1
- UniProtKB: Q0ZLZ2 (UniProtKB/Swiss-Prot),   P06296 (UniProtKB/Swiss-Prot),   O62637 (UniProtKB/Swiss-Prot),   Q8HZV1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001106533   ⟸   NM_001113062
- Peptide Label: precursor
- UniProtKB: Q0ZLZ2 (UniProtKB/Swiss-Prot),   O62637 (UniProtKB/Swiss-Prot),   Q8HZV1 (UniProtKB/Swiss-Prot),   P06296 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSSSCP00000006626   ⟸   ENSSSCT00000006811
Ensembl Acc Id: ENSSSCP00000067099   ⟸   ENSSSCT00000090438


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006215 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00015015252 UniProtKB/Swiss-Prot
  ENSSSCG00025021688 UniProtKB/Swiss-Prot
  ENSSSCG00030033445 UniProtKB/Swiss-Prot
  ENSSSCG00035017872 UniProtKB/Swiss-Prot
  ENSSSCG00040029641 UniProtKB/Swiss-Prot
  ENSSSCG00045010902 UniProtKB/Swiss-Prot
  ENSSSCG00050017351 UniProtKB/Swiss-Prot
  ENSSSCG00055011116 UniProtKB/Swiss-Prot
  ENSSSCG00060051620 UniProtKB/Swiss-Prot
  ENSSSCG00065068899 UniProtKB/Swiss-Prot
  ENSSSCG00070020495 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000006811 ENTREZGENE
  ENSSSCT00000006811.4 UniProtKB/Swiss-Prot
  ENSSSCT00015020175.1 UniProtKB/Swiss-Prot
  ENSSSCT00015020200.1 UniProtKB/Swiss-Prot
  ENSSSCT00025029486.1 UniProtKB/Swiss-Prot
  ENSSSCT00025029504.1 UniProtKB/Swiss-Prot
  ENSSSCT00030046261.1 UniProtKB/Swiss-Prot
  ENSSSCT00030046286.1 UniProtKB/Swiss-Prot
  ENSSSCT00035023013.1 UniProtKB/Swiss-Prot
  ENSSSCT00035023017.1 UniProtKB/Swiss-Prot
  ENSSSCT00040039833.1 UniProtKB/Swiss-Prot
  ENSSSCT00040039880.1 UniProtKB/Swiss-Prot
  ENSSSCT00045018533.1 UniProtKB/Swiss-Prot
  ENSSSCT00045018560.1 UniProtKB/Swiss-Prot
  ENSSSCT00050023611.1 UniProtKB/Swiss-Prot
  ENSSSCT00050023618.1 UniProtKB/Swiss-Prot
  ENSSSCT00055021798.1 UniProtKB/Swiss-Prot
  ENSSSCT00055021821.1 UniProtKB/Swiss-Prot
  ENSSSCT00060070263.1 UniProtKB/Swiss-Prot
  ENSSSCT00060070268.1 UniProtKB/Swiss-Prot
  ENSSSCT00065094580.1 UniProtKB/Swiss-Prot
  ENSSSCT00065094586.1 UniProtKB/Swiss-Prot
  ENSSSCT00070040731.1 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.250.1920 UniProtKB/Swiss-Prot
InterPro Corticotropin-releasing_fac_CS UniProtKB/Swiss-Prot
  CRF UniProtKB/Swiss-Prot
  Urocortin_CRF UniProtKB/Swiss-Prot
KEGG Report ssc:100127468 UniProtKB/Swiss-Prot
NCBI Gene CRH ENTREZGENE
PANTHER CORTICOLIBERIN UniProtKB/Swiss-Prot
  PTHR15035 UniProtKB/Swiss-Prot
Pfam CRF UniProtKB/Swiss-Prot
PRINTS CRFFAMILY UniProtKB/Swiss-Prot
PROSITE CRF UniProtKB/Swiss-Prot
SMART CRF UniProtKB/Swiss-Prot
UniProt CRF_PIG UniProtKB/Swiss-Prot
  O62637 ENTREZGENE
  P06296 ENTREZGENE
  Q0ZLZ2 ENTREZGENE
  Q8HZV1 ENTREZGENE
UniProt Secondary O62637 UniProtKB/Swiss-Prot
  Q0ZLZ2 UniProtKB/Swiss-Prot
  Q8HZV1 UniProtKB/Swiss-Prot
VGNC ID VGNC:86992 ENTREZGENE