JUN (Jun proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: JUN (Jun proto-oncogene, AP-1 transcription factor subunit) Sus scrofa
Analyze
Symbol: JUN
Name: Jun proto-oncogene, AP-1 transcription factor subunit
RGD ID: 14217642
Description: ENCODES a protein that exhibits DNA binding; chromatin binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN cellular response to lipopolysaccharide; immune response; positive regulation of DNA-binding transcription factor activity; PARTICIPATES IN adenosine signaling pathway; endothelin signaling pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH Alcohol-Related Disorders (ortholog); angiosarcoma (ortholog); Asphyxia (ortholog); FOUND IN nucleus; chromatin (ortholog); protein-containing complex (ortholog); INTERACTS WITH cadmium atom; cadmium dichloride; clofibrate
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: activator protein 1; AP1; C-JUN; proto-oncogene c-jun; transcription factor AP-1; transcription factor AP-1 subunit Jun; transcription factor Jun; V-jun avian sarcoma virus 17 oncogene homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6153,685,682 - 153,687,636 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16153,686,425 - 153,687,635 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26141,231,122 - 141,232,332 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
apoptotic process  (ISO)
axon regeneration  (ISO)
cell population proliferation  (ISO)
cellular response to anisomycin  (ISO)
cellular response to calcium ion  (ISO)
cellular response to hypoxia  (ISO)
cellular response to lipopolysaccharide  (IDA)
cellular response to potassium ion starvation  (ISO)
cellular response to prolactin  (ISO)
cellular response to zinc ion starvation  (ISO)
circadian rhythm  (ISO)
DNA-templated transcription  (ISO)
eyelid development in camera-type eye  (ISO)
immune response  (IDA)
leading edge cell differentiation  (ISO)
learning  (ISO)
liver development  (ISO)
membrane depolarization  (ISO)
microglial cell activation  (ISO)
monocyte differentiation  (ISO)
negative regulation by host of viral transcription  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein autophosphorylation  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
outflow tract morphogenesis  (ISO)
positive regulation by host of viral transcription  (IEA)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of DNA-binding transcription factor activity  (IMP)
positive regulation of DNA-templated transcription  (IEA,IMP,ISS)
positive regulation of DNA-templated transcription initiation  (IEA)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of miRNA transcription  (IEA)
positive regulation of monocyte differentiation  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,ISO,ISS)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA)
regulation of cell cycle  (IBA,ISO)
regulation of cell population proliferation  (IBA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA)
release from viral latency  (IEA)
release of cytochrome c from mitochondria  (ISO)
response to cAMP  (ISO)
response to cytokine  (ISO)
response to endoplasmic reticulum stress  (IEA)
response to ethanol  (ISO)
response to forskolin  (ISO)
response to hydrogen peroxide  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to muscle stretch  (ISO)
response to steroid hormone  (IBA,ISO)
response to xenobiotic stimulus  (ISO)
SMAD protein signal transduction  (IEA)
transcription by RNA polymerase II  (ISO)
transforming growth factor beta receptor signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:8793856   PMID:8898353   PMID:14681463   PMID:22083952   PMID:23089279   PMID:25110868   PMID:28347884   PMID:28931675   PMID:30032202   PMID:32772776   PMID:33930700  


Genomics

Comparative Map Data
JUN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6153,685,682 - 153,687,636 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16153,686,425 - 153,687,635 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26141,231,122 - 141,232,332 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JUN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38158,780,791 - 58,784,047 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl158,776,845 - 58,784,048 (-)EnsemblGRCh38hg38GRCh38
GRCh37159,246,463 - 59,249,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36159,019,051 - 59,022,373 (-)NCBINCBI36Build 36hg18NCBI36
Build 34158,958,483 - 58,961,806NCBI
Celera157,530,296 - 57,533,618 (-)NCBICelera
Cytogenetic Map1p32.1NCBI
HuRef157,356,787 - 57,360,109 (-)NCBIHuRef
CHM1_1159,361,828 - 59,365,150 (-)NCBICHM1_1
T2T-CHM13v2.0158,659,236 - 58,662,492 (-)NCBIT2T-CHM13v2.0
Jun
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39494,937,273 - 94,940,459 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl494,937,271 - 94,940,459 (-)EnsemblGRCm39 Ensembl
GRCm38495,049,036 - 95,052,222 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl495,049,034 - 95,052,222 (-)EnsemblGRCm38mm10GRCm38
MGSCv37494,715,727 - 94,718,913 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36494,541,073 - 94,544,205 (-)NCBIMGSCv36mm8
Celera493,436,543 - 93,439,728 (-)NCBICelera
Cytogenetic Map4C5NCBI
cM Map443.34NCBI
Jun
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85115,009,900 - 115,012,993 (-)NCBIGRCr8
mRatBN7.25109,894,175 - 109,897,268 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5109,893,145 - 109,897,656 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5112,464,752 - 112,467,841 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05114,190,270 - 114,193,359 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05114,252,804 - 114,255,893 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05114,011,184 - 114,014,277 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5114,011,189 - 114,014,277 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05117,957,730 - 117,960,823 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45115,358,166 - 115,361,259 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15115,363,396 - 115,365,980 (-)NCBI
Celera5108,510,040 - 108,513,133 (-)NCBICelera
Cytogenetic Map5q33NCBI
Jun
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554641,107,598 - 1,110,326 (+)NCBIChiLan1.0ChiLan1.0
JUN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21168,063,962 - 168,067,574 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11167,218,036 - 167,219,853 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0158,042,794 - 58,045,536 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1159,747,129 - 59,750,446 (-)NCBIpanpan1.1PanPan1.1panPan2
JUN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1550,966,698 - 50,968,939 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha551,033,459 - 51,034,786 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0551,147,773 - 51,149,113 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl551,148,001 - 51,149,014 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1551,098,106 - 51,099,438 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0551,043,349 - 51,044,688 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0551,326,980 - 51,328,311 (+)NCBIUU_Cfam_GSD_1.0
Jun
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505872,379,192 - 72,381,903 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365223,035,346 - 3,036,350 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365223,034,364 - 3,037,632 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JUN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12074,204,481 - 74,207,835 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2074,205,542 - 74,206,546 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603343,155,224 - 43,158,790 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Jun
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248621,538,455 - 1,539,426 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248621,537,886 - 1,540,633 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in JUN
44 total Variants

Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSSCT00000057200   ⟹   ENSSSCP00000078233
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6153,685,682 - 153,687,636 (+)Ensembl
RefSeq Acc Id: NM_213880   ⟹   NP_999045
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16153,686,425 - 153,687,635 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999045 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB50808 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000078233
  ENSSSCP00000078233.1
  ENSSSCP00070051691.1
GenBank Protein P56432 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_999045   ⟸   NM_213880
- UniProtKB: P56432 (UniProtKB/Swiss-Prot),   A0A4X1WB31 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000078233   ⟸   ENSSSCT00000057200
Protein Domains
bZIP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000031912 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070030158 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000057200 ENTREZGENE
  ENSSSCT00000057200.3 UniProtKB/TrEMBL
  ENSSSCT00070060650.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AP-1_TF_bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  JNK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leuzip_Jun UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396913 UniProtKB/Swiss-Prot
NCBI Gene JUN ENTREZGENE
PANTHER JUN TRANSCRIPTION FACTOR-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11462:SF8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Jun UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS LEUZIPPRJUN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP A DNA-binding domain in eukaryotic transcription factors UniProtKB/TrEMBL
  Leucine zipper domain UniProtKB/TrEMBL
  SSF47454 UniProtKB/Swiss-Prot
  SSF57959 UniProtKB/Swiss-Prot
UniProt A0A4X1WB31 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FIU6_PIG UniProtKB/TrEMBL
  JUN_PIG UniProtKB/Swiss-Prot, ENTREZGENE