HSPD1 (heat shock protein family D (Hsp60) member 1) - Rat Genome Database

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Gene: HSPD1 (heat shock protein family D (Hsp60) member 1) Sus scrofa
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Symbol: HSPD1
Name: heat shock protein family D (Hsp60) member 1
RGD ID: 14202796
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activator activity (ortholog); modification-dependent protein binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN adhesion of symbiont to host (ortholog); apoptotic mitochondrial changes (ortholog); cellular response to heat (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); adenocarcinoma (ortholog); Alzheimer's disease (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); Golgi cisterna (ortholog); INTERACTS WITH chloroquine; ochratoxin A
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 60 kDa heat shock protein, mitochondrial; heat shock 60 kDa protein 1; HSP60; mitochondrial heat shock 60 kDa protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15101,360,094 - 101,373,526 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115101,360,355 - 101,373,498 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215112,534,459 - 112,547,603 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adhesion of symbiont to host  (ISO)
apoptotic mitochondrial changes  (ISO)
B cell activation  (IEA)
B cell proliferation  (IEA)
biological process involved in interaction with symbiont  (IEA)
cellular response to heat  (ISO)
cellular response to interleukin-7  (IEA,ISO)
isotype switching to IgG isotypes  (IEA)
MyD88-dependent toll-like receptor signaling pathway  (IEA)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of apoptotic process in bone marrow cell  (ISO)
negative regulation of execution phase of apoptosis  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of apoptotic process  (IEA)
positive regulation of execution phase of apoptosis  (ISO)
positive regulation of interferon-alpha production  (IEA,ISO)
positive regulation of interleukin-10 production  (IEA)
positive regulation of interleukin-12 production  (IEA)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of macrophage activation  (IEA)
positive regulation of T cell activation  (IEA)
positive regulation of T cell mediated immune response to tumor cell  (IEA)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type II interferon production  (IEA,ISO)
protein refolding  (IEA)
protein stabilization  (IEA)
response to activity  (ISO)
response to ATP  (ISO)
response to cocaine  (ISO)
response to cold  (ISS)
response to estrogen  (ISO)
response to glucocorticoid  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to ischemia  (ISO)
response to lipopolysaccharide  (ISO)
response to resveratrol  (ISO)
response to unfolded protein  (IEA)
response to xenobiotic stimulus  (ISO)
T cell activation  (IEA,ISO)

References
Additional References at PubMed
PMID:14681463   PMID:18548335   PMID:22301074   PMID:26427351   PMID:29208924   PMID:30032202  


Genomics

Comparative Map Data
HSPD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15101,360,094 - 101,373,526 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115101,360,355 - 101,373,498 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215112,534,459 - 112,547,603 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSPD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382197,486,584 - 197,500,274 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2197,486,584 - 197,516,737 (-)EnsemblGRCh38hg38GRCh38
GRCh372198,351,308 - 198,364,998 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362198,059,553 - 198,073,243 (-)NCBINCBI36Build 36hg18NCBI36
Build 342198,176,815 - 198,190,504NCBI
Celera2192,107,181 - 192,120,871 (-)NCBICelera
Cytogenetic Map2q33.1NCBI
HuRef2190,203,711 - 190,217,402 (-)NCBIHuRef
CHM1_12198,357,144 - 198,370,838 (-)NCBICHM1_1
T2T-CHM13v2.02197,970,209 - 197,983,875 (-)NCBIT2T-CHM13v2.0
Hspd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39155,116,992 - 55,127,402 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl155,116,994 - 55,127,402 (-)EnsemblGRCm39 Ensembl
GRCm38155,077,833 - 55,088,243 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl155,077,835 - 55,088,243 (-)EnsemblGRCm38mm10GRCm38
MGSCv37155,134,678 - 55,144,776 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36155,022,380 - 55,032,390 (-)NCBIMGSCv36mm8
Celera155,597,904 - 55,608,002 (-)NCBICelera
Cytogenetic Map1C1.2NCBI
cM Map128.01NCBI
Hspd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8964,073,610 - 64,084,332 (-)NCBIGRCr8
mRatBN7.2956,579,195 - 56,590,011 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl956,579,201 - 56,589,662 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx965,088,118 - 65,098,576 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0970,204,015 - 70,214,473 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0968,503,767 - 68,514,191 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0961,680,529 - 61,691,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl961,680,530 - 61,690,956 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0961,361,745 - 61,372,414 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4953,884,193 - 53,895,043 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1953,885,606 - 53,895,580 (-)NCBI
Celera954,060,669 - 54,071,096 (-)NCBICelera
Cytogenetic Map9q31NCBI
Hspd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554033,063,133 - 3,073,419 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554033,062,724 - 3,073,419 (+)NCBIChiLan1.0ChiLan1.0
HSPD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213100,100,280 - 100,114,129 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B100,115,490 - 100,129,121 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B84,729,615 - 84,743,352 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B202,623,497 - 202,637,045 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B202,623,497 - 202,636,959 (-)Ensemblpanpan1.1panPan2
HSPD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1377,010,421 - 7,025,912 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha377,956,566 - 7,967,852 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0376,900,931 - 6,911,990 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl376,900,933 - 6,911,980 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1376,899,765 - 6,910,835 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0376,866,679 - 6,877,757 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0376,889,830 - 6,900,900 (-)NCBIUU_Cfam_GSD_1.0
Hspd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303155,150,440 - 155,160,005 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365061,678,069 - 1,687,632 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11083,003,266 - 83,017,397 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1083,003,717 - 83,017,363 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040116,426,692 - 116,441,017 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hspd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248892,736,727 - 2,746,333 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HSPD1
321 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000064449   ⟹   ENSSSCP00000047456
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15101,360,094 - 101,373,526 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000102732   ⟹   ENSSSCP00000079655
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15101,360,098 - 101,373,504 (-)Ensembl
RefSeq Acc Id: NM_001254716   ⟹   NP_001241645
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115101,360,355 - 101,373,498 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001241645 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAV40980 (Get FASTA)   NCBI Sequence Viewer  
  AET99216 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000047456.1
  ENSSSCP00000079655
  ENSSSCP00000079655.1
  ENSSSCP00070039927.1
RefSeq Acc Id: NP_001241645   ⟸   NM_001254716
- UniProtKB: G9F6X6 (UniProtKB/TrEMBL),   A0A4X1VEW0 (UniProtKB/TrEMBL),   A0A8D0I470 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000047456   ⟸   ENSSSCT00000064449
Ensembl Acc Id: ENSSSCP00000079655   ⟸   ENSSSCT00000102732


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000016077 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070023722 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000064449.3 UniProtKB/TrEMBL
  ENSSSCT00000102732 ENTREZGENE
  ENSSSCT00000102732.1 UniProtKB/TrEMBL
  ENSSSCT00070047321.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.560.10 UniProtKB/TrEMBL
  3.30.260.10 UniProtKB/TrEMBL
  3.50.7.10 UniProtKB/TrEMBL
InterPro Chaperonin_Cpn60_CS UniProtKB/TrEMBL
  Chaprnin_Cpn60 UniProtKB/TrEMBL
  Cpn60/TCP-1 UniProtKB/TrEMBL
  GroEL-like_apical_dom_sf UniProtKB/TrEMBL
  GROEL-like_equatorial_sf UniProtKB/TrEMBL
  TCP-1-like_intermed_sf UniProtKB/TrEMBL
KEGG Report ssc:492279 UniProtKB/TrEMBL
NCBI Gene HSPD1 ENTREZGENE
PANTHER 60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL UniProtKB/TrEMBL
  60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam Cpn60_TCP1 UniProtKB/TrEMBL
PRINTS CHAPERONIN60 UniProtKB/TrEMBL
PROSITE CHAPERONINS_CPN60 UniProtKB/TrEMBL
Superfamily-SCOP SSF48592 UniProtKB/TrEMBL
  SSF52029 UniProtKB/TrEMBL
  SSF54849 UniProtKB/TrEMBL
UniProt A0A4X1VDY5_PIG UniProtKB/TrEMBL
  A0A4X1VEW0 ENTREZGENE
  A0A8D0I470 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FMW6_PIG UniProtKB/TrEMBL
  G9F6X6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A287ATN8 UniProtKB/TrEMBL