HSPA5 (heat shock protein family A (Hsp70) member 5) - Rat Genome Database

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Gene: HSPA5 (heat shock protein family A (Hsp70) member 5) Sus scrofa
Analyze
Symbol: HSPA5
Name: heat shock protein family A (Hsp70) member 5
RGD ID: 14191050
Description: ENCODES a protein that exhibits ATP hydrolysis activity (ortholog); unfolded protein binding (ortholog); INVOLVED IN cellular response to antibiotic (ortholog); cellular response to calcium ion (ortholog); cellular response to cAMP (ortholog); PARTICIPATES IN codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; etoposide pharmacodynamics pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Acute Lung Injury (ortholog); asbestosis (ortholog); FOUND IN COP9 signalosome (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 1,4-dithiothreitol; 3-acetyldeoxynivalenol; 4-phenylbutyric acid
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 78 kDa glucose-regulated protein; BIP; glucose-regulated protein, 78kDa; GRP78
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1265,930,045 - 265,934,894 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11265,930,044 - 265,934,959 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21299,754,103 - 299,758,617 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q2.10-q2.13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to antibiotic  (ISO)
cellular response to calcium ion  (ISO)
cellular response to cAMP  (ISO)
cellular response to gamma radiation  (ISO)
cellular response to glucose starvation  (IEA)
cellular response to interleukin-4  (IEA,ISO)
cellular response to manganese ion  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
cerebellar Purkinje cell layer development  (IEA)
cerebellum structural organization  (IEA)
chaperone cofactor-dependent protein refolding  (IBA)
chromatin looping  (IEA)
chromatin remodeling  (IEA)
endoplasmic reticulum unfolded protein response  (IBA,IEA)
ER overload response  (IEA,ISO)
ERAD pathway  (IBA)
IRE1-mediated unfolded protein response  (ISO)
luteolysis  (ISO)
maintenance of protein localization in endoplasmic reticulum  (IEA,ISS)
negative regulation of apoptotic process  (IEA)
negative regulation of IRE1-mediated unfolded protein response  (ISS)
negative regulation of PERK-mediated unfolded protein response  (IEA)
negative regulation of protein-containing complex assembly  (ISS)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
neuron apoptotic process  (ISO)
neuron differentiation  (ISO)
positive regulation of cell migration  (IEA,ISS)
positive regulation of neuron projection development  (ISO)
positive regulation of protein ubiquitination  (IEA)
post-translational protein targeting to membrane, translocation  (IEA,ISS)
protein folding  (IEA)
protein refolding  (IBA)
proteolysis involved in protein catabolic process  (IEA)
response to cocaine  (ISO)
response to endoplasmic reticulum stress  (ISO)
response to methamphetamine hydrochloride  (ISO)
stress response to metal ion  (ISO)
substantia nigra development  (ISO)

References
Additional References at PubMed
PMID:3360780   PMID:8104765   PMID:11683720   PMID:14681463   PMID:17145712   PMID:22301074   PMID:26907328   PMID:30032202   PMID:32957618   PMID:37222617  


Genomics

Comparative Map Data
HSPA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1265,930,045 - 265,934,894 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11265,930,044 - 265,934,959 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21299,754,103 - 299,758,617 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q2.10-q2.13NCBI
HSPA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389125,234,853 - 125,241,343 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9125,234,853 - 125,241,382 (-)EnsemblGRCh38hg38GRCh38
GRCh379127,997,132 - 128,003,622 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369127,036,953 - 127,043,430 (-)NCBINCBI36Build 36hg18NCBI36
Build 349125,076,687 - 125,083,163NCBI
Celera998,645,114 - 98,651,649 (-)NCBICelera
Cytogenetic Map9q33.3NCBI
HuRef997,609,713 - 97,616,253 (-)NCBIHuRef
CHM1_19128,146,874 - 128,153,413 (-)NCBICHM1_1
T2T-CHM13v2.09137,433,170 - 137,439,661 (-)NCBIT2T-CHM13v2.0
Hspa5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39234,662,102 - 34,666,541 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl234,661,982 - 34,667,559 (+)EnsemblGRCm39 Ensembl
GRCm38234,772,090 - 34,776,529 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl234,771,970 - 34,777,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv37234,627,610 - 34,632,049 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36234,594,104 - 34,598,466 (+)NCBIMGSCv36mm8
Celera234,472,567 - 34,477,006 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.94NCBI
Hspa5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8338,453,016 - 38,457,475 (+)NCBIGRCr8
mRatBN7.2318,055,507 - 18,059,969 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl318,055,405 - 18,059,891 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx321,123,611 - 21,128,067 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0329,708,632 - 29,713,088 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0327,962,245 - 27,966,702 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0313,838,304 - 13,842,763 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl313,838,304 - 13,842,762 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0319,157,874 - 19,162,333 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4313,783,825 - 13,788,022 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1313,680,196 - 13,684,394 (+)NCBI
Celera312,776,654 - 12,781,113 (+)NCBICelera
RH 3.4 Map3151.7RGD
Cytogenetic Map3p11NCBI
Hspa5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554193,055,420 - 3,062,131 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554193,055,420 - 3,060,208 (+)NCBIChiLan1.0ChiLan1.0
HSPA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21114,121,462 - 14,127,266 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1914,124,169 - 14,129,621 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0996,351,645 - 96,356,761 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19124,865,211 - 124,870,458 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9124,865,211 - 124,870,458 (-)Ensemblpanpan1.1panPan2
HSPA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1957,850,870 - 57,855,607 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl957,850,922 - 57,855,257 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha957,050,544 - 57,055,478 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0958,771,363 - 58,776,290 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl958,771,414 - 58,776,279 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1957,529,524 - 57,534,454 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0957,846,243 - 57,851,163 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0957,936,913 - 57,941,842 (+)NCBIUU_Cfam_GSD_1.0
Hspa5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947193,579,938 - 193,584,190 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648713,348,465 - 13,352,717 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648713,348,465 - 13,352,717 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11212,920,705 - 12,925,888 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1212,920,710 - 12,927,431 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660793,184,743 - 3,190,031 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hspa5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247609,986,656 - 9,995,252 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247609,986,529 - 9,991,261 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HSPA5
191 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000048425   ⟹   ENSSSCP00000055982
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1265,930,045 - 265,934,894 (-)Ensembl
RefSeq Acc Id: XM_001927795   ⟹   XP_001927830
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11265,930,044 - 265,934,959 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021068830   ⟹   XP_020924489
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11265,930,044 - 265,934,904 (-)NCBI
Sequence:
RefSeq Acc Id: XP_001927830   ⟸   XM_001927795
- Peptide Label: isoform X2
- UniProtKB: A0A480UES1 (UniProtKB/TrEMBL),   A0A4X1UFV5 (UniProtKB/TrEMBL),   A0A8D1M4S6 (UniProtKB/TrEMBL),   A0A8D1BPZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020924489   ⟸   XM_021068830
- Peptide Label: isoform X1
- UniProtKB: A0A287BIL8 (UniProtKB/TrEMBL),   A0A4X1UEN5 (UniProtKB/TrEMBL),   A0A8D2BVH4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000055982   ⟸   ENSSSCT00000048425


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000005601 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015023414 UniProtKB/TrEMBL
  ENSSSCG00025029618 UniProtKB/TrEMBL
  ENSSSCG00030047245 UniProtKB/TrEMBL
  ENSSSCG00035080321 UniProtKB/TrEMBL
  ENSSSCG00040002246 UniProtKB/TrEMBL
  ENSSSCG00045035376 UniProtKB/TrEMBL
  ENSSSCG00050033163 UniProtKB/TrEMBL
  ENSSSCG00055026810 UniProtKB/TrEMBL
  ENSSSCG00060077727 UniProtKB/TrEMBL
  ENSSSCG00065046551 UniProtKB/TrEMBL
  ENSSSCG00070016341 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000048425 ENTREZGENE
  ENSSSCT00000048425.3 UniProtKB/TrEMBL
  ENSSSCT00015031112.1 UniProtKB/TrEMBL
  ENSSSCT00025040254.1 UniProtKB/TrEMBL
  ENSSSCT00030065959.1 UniProtKB/TrEMBL
  ENSSSCT00035109967.1 UniProtKB/TrEMBL
  ENSSSCT00035109985.1 UniProtKB/TrEMBL
  ENSSSCT00035110012.1 UniProtKB/TrEMBL
  ENSSSCT00040002704.1 UniProtKB/TrEMBL
  ENSSSCT00040002721.1 UniProtKB/TrEMBL
  ENSSSCT00040002757.1 UniProtKB/TrEMBL
  ENSSSCT00045060757.1 UniProtKB/TrEMBL
  ENSSSCT00050044477.1 UniProtKB/TrEMBL
  ENSSSCT00050044490.1 UniProtKB/TrEMBL
  ENSSSCT00055052962.1 UniProtKB/TrEMBL
  ENSSSCT00055053103.1 UniProtKB/TrEMBL
  ENSSSCT00055053128.1 UniProtKB/TrEMBL
  ENSSSCT00060107133.1 UniProtKB/TrEMBL
  ENSSSCT00065063696.1 UniProtKB/TrEMBL
  ENSSSCT00065063717.1 UniProtKB/TrEMBL
  ENSSSCT00065063727.1 UniProtKB/TrEMBL
  ENSSSCT00070032163.1 UniProtKB/TrEMBL
  ENSSSCT00070032177.1 UniProtKB/TrEMBL
  ENSSSCT00070032190.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.30.30 UniProtKB/TrEMBL
  3.30.420.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIP_NBD UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:407060 UniProtKB/TrEMBL
NCBI Gene HSPA5 ENTREZGENE
PANTHER ENDOPLASMIC RETICULUM CHAPERONE BIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19375 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HSP70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HEATSHOCK70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HSP70_1 UniProtKB/TrEMBL
  HSP70_2 UniProtKB/TrEMBL
  HSP70_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF100934 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287BIL8 ENTREZGENE, UniProtKB/TrEMBL
  A0A480UES1 ENTREZGENE
  A0A4X1UEN5 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UEP5_PIG UniProtKB/TrEMBL
  A0A4X1UFV5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1BPZ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1M4S6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D2BVH4 ENTREZGENE, UniProtKB/TrEMBL
  BIP_PIG UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A480UES1 UniProtKB/TrEMBL
VGNC ID VGNC:103107 ENTREZGENE