CCNB1 (cyclin B1) - Rat Genome Database

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Gene: CCNB1 (cyclin B1) Sus scrofa
Analyze
Symbol: CCNB1
Name: cyclin B1
RGD ID: 14154597
Description: ENCODES a protein that exhibits histone kinase activity; protein kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN negative regulation of meiotic cell cycle process involved in oocyte maturation; cellular response to fatty acid (ortholog); cellular response to hypoxia (ortholog); ASSOCIATED WITH breast cancer (ortholog); cervical cancer (ortholog); COVID-19 (ortholog); FOUND IN centrosome (inferred); cyclin B1-CDK1 complex (inferred); cytoplasm (inferred); INTERACTS WITH benzo[a]pyrene; caffeine; copper(II) sulfate
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cyclin B; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1647,338,110 - 47,348,377 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11647,338,239 - 47,348,385 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,155,615 - 51,165,760 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell division  (IEA)
cellular response to fatty acid  (ISO)
cellular response to hypoxia  (ISO)
cellular response to iron(III) ion  (ISO)
cellular response to organic cyclic compound  (ISO)
chromatin remodeling  (IEA)
digestive tract development  (ISO)
G1/S transition of mitotic cell cycle  (IBA)
in utero embryonic development  (IEA,ISO)
mitotic cell cycle phase transition  (IEA)
mitotic metaphase chromosome alignment  (IBA,IEA)
mitotic spindle organization  (IEA)
negative regulation of gene expression  (ISO)
negative regulation of meiotic cell cycle process involved in oocyte maturation  (IMP)
negative regulation of protein phosphorylation  (ISO)
oocyte maturation  (ISO)
positive regulation of attachment of spindle microtubules to kinetochore  (IEA)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell cycle  (IEA,ISO)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of G2/M transition of mitotic cell cycle  (IEA)
positive regulation of mitochondrial ATP synthesis coupled electron transport  (IEA)
positive regulation of mitotic cell cycle  (IEA)
positive regulation of mRNA 3'-end processing  (ISO)
positive regulation of protein kinase activity  (ISO)
protein phosphorylation  (ISO)
protein-containing complex assembly  (ISO)
regulation of chromosome condensation  (ISO)
regulation of mitotic cell cycle spindle assembly checkpoint  (IEA)
response to DDT  (ISO)
response to mechanical stimulus  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (ISO)
spermatogenesis  (ISO)
tissue regeneration  (ISO)
ventricular cardiac muscle cell development  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:15278898   PMID:16319287   PMID:19705412   PMID:22301074   PMID:24626152   PMID:27744448   PMID:30032202  


Genomics

Comparative Map Data
CCNB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1647,338,110 - 47,348,377 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11647,338,239 - 47,348,385 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,155,615 - 51,165,760 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCNB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38569,167,150 - 69,178,245 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl569,167,135 - 69,178,245 (+)EnsemblGRCh38hg38GRCh38
GRCh37568,462,977 - 68,474,072 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36568,498,669 - 68,509,828 (+)NCBINCBI36Build 36hg18NCBI36
Build 34568,498,668 - 68,509,824NCBI
Celera565,462,166 - 65,473,328 (+)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef565,418,249 - 65,429,485 (+)NCBIHuRef
CHM1_1568,462,558 - 68,473,793 (+)NCBICHM1_1
T2T-CHM13v2.0569,989,760 - 70,000,851 (+)NCBIT2T-CHM13v2.0
Ccnb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913100,915,247 - 100,922,994 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13100,915,158 - 100,923,078 (-)EnsemblGRCm39 Ensembl
GRCm3813100,778,739 - 100,786,486 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13100,778,650 - 100,786,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713101,548,694 - 101,556,441 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613101,878,996 - 101,886,743 (-)NCBIMGSCv36mm8
Celera13104,387,574 - 104,395,322 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.23NCBI
Ccnb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8233,646,252 - 33,655,225 (-)NCBIGRCr8
mRatBN7.2231,912,190 - 31,921,163 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,912,193 - 31,921,172 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx239,046,390 - 39,055,360 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0237,087,590 - 37,096,347 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0231,945,688 - 31,954,752 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0230,782,133 - 30,791,106 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,783,915 - 30,791,221 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0249,941,586 - 49,948,770 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4231,574,600 - 31,581,784 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1231,493,947 - 31,502,123 (-)NCBI
Celera227,925,441 - 27,934,414 (-)NCBICelera
Cytogenetic Map2q12NCBI
Ccnb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955446140,093 - 149,500 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955446140,661 - 149,500 (-)NCBIChiLan1.0ChiLan1.0
CCNB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2444,745,330 - 44,756,107 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1542,898,956 - 42,909,733 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0544,826,103 - 44,836,832 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1546,394,362 - 46,405,332 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl546,394,362 - 46,405,332 (-)Ensemblpanpan1.1panPan2
CCNB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,256,957 - 54,264,749 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha251,223,809 - 51,231,591 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0254,767,756 - 54,775,584 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1251,827,069 - 51,834,879 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0252,602,043 - 52,609,862 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0253,489,618 - 53,497,458 (+)NCBIUU_Cfam_GSD_1.0
Ccnb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213191,463,462 - 191,471,154 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936480399,224 - 407,704 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936480400,287 - 407,677 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCNB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1465,265,798 - 65,276,465 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl465,265,844 - 65,277,085 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604913,995,123 - 14,005,792 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in CCNB1
274 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000024108   ⟹   ENSSSCP00000023163
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1647,338,110 - 47,348,377 (+)Ensembl
RefSeq Acc Id: NM_001170768   ⟹   NP_001164239
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11647,338,239 - 47,348,385 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001164239   ⟸   NM_001170768
- UniProtKB: D2IE28 (UniProtKB/TrEMBL),   A0A8D0S4R5 (UniProtKB/TrEMBL),   A0A4X1UFG8 (UniProtKB/TrEMBL),   A0A8D0WXL9 (UniProtKB/TrEMBL),   A0A8D0J9K7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000023163   ⟸   ENSSSCT00000024108
Protein Domains
Cyclin C-terminal   Cyclin-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000029326 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015046698 UniProtKB/TrEMBL
  ENSSSCG00025044799 UniProtKB/TrEMBL
  ENSSSCG00030044198 UniProtKB/TrEMBL
  ENSSSCG00035036070 UniProtKB/TrEMBL
  ENSSSCG00040064532 UniProtKB/TrEMBL
  ENSSSCG00045014304 UniProtKB/TrEMBL
  ENSSSCG00050054281 UniProtKB/TrEMBL
  ENSSSCG00055020200 UniProtKB/TrEMBL
  ENSSSCG00060030421 UniProtKB/TrEMBL
  ENSSSCG00065074762 UniProtKB/TrEMBL
  ENSSSCG00070017445 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000024108 ENTREZGENE
  ENSSSCT00000024108.4 UniProtKB/TrEMBL
  ENSSSCT00015062324.1 UniProtKB/TrEMBL
  ENSSSCT00025060821.1 UniProtKB/TrEMBL
  ENSSSCT00030061638.1 UniProtKB/TrEMBL
  ENSSSCT00035047810.1 UniProtKB/TrEMBL
  ENSSSCT00040088128.1 UniProtKB/TrEMBL
  ENSSSCT00045024386.1 UniProtKB/TrEMBL
  ENSSSCT00050074012.1 UniProtKB/TrEMBL
  ENSSSCT00055039625.1 UniProtKB/TrEMBL
  ENSSSCT00060041100.1 UniProtKB/TrEMBL
  ENSSSCT00065103012.1 UniProtKB/TrEMBL
  ENSSSCT00070034444.1 UniProtKB/TrEMBL
Gene3D-CATH Cyclin-like UniProtKB/TrEMBL
InterPro CCNB1_first_cyclin-box UniProtKB/TrEMBL
  Cyclin UniProtKB/TrEMBL
  Cyclin-like UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/TrEMBL
  Cyclin_A/B-like UniProtKB/TrEMBL
  Cyclin_C-dom UniProtKB/TrEMBL
  Cyclin_N UniProtKB/TrEMBL
  Cyclins_cyclin-box UniProtKB/TrEMBL
KEGG Report ssc:397662 UniProtKB/TrEMBL
NCBI Gene CCNB1 ENTREZGENE
PANTHER G2/MITOTIC-SPECIFIC CYCLIN-B1 UniProtKB/TrEMBL
  PTHR10177 UniProtKB/TrEMBL
Pfam Cyclin_C UniProtKB/TrEMBL
  Cyclin_N UniProtKB/TrEMBL
PIRSF Cyclin_A_B_D_E UniProtKB/TrEMBL
PROSITE CYCLINS UniProtKB/TrEMBL
SMART CYCLIN UniProtKB/TrEMBL
  Cyclin_C UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/TrEMBL
UniProt A0A4X1UFG8 ENTREZGENE
  A0A8D0J9K7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0S4R5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0WXL9 ENTREZGENE, UniProtKB/TrEMBL
  D2IE28 ENTREZGENE, UniProtKB/TrEMBL
  H2AM22_PIG UniProtKB/TrEMBL
  H2AM23_PIG UniProtKB/TrEMBL
VGNC ID VGNC:86349 ENTREZGENE