ATOX1 (antioxidant 1 copper chaperone) - Rat Genome Database

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Gene: ATOX1 (antioxidant 1 copper chaperone) Sus scrofa
Analyze
Symbol: ATOX1
Name: antioxidant 1 copper chaperone
RGD ID: 14150045
Description: ENCODES a protein that exhibits ATPase binding (ortholog); copper chaperone activity (ortholog); copper ion binding (ortholog); INVOLVED IN copper ion export (ortholog); copper ion transport (ortholog); intracellular copper ion homeostasis (ortholog); PARTICIPATES IN cisplatin drug pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Chronic Hepatitis (ortholog); Colorectal Neoplasms (ortholog); INTERACTS WITH copper(II) sulfate
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: antioxidant protein 1 homolog; ATX1 antioxidant protein 1 homolog; copper transport protein ATOX1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1671,299,321 - 71,314,597 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11671,299,321 - 71,314,598 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21677,444,306 - 77,444,387 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:15679890   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ATOX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1671,299,321 - 71,314,597 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11671,299,321 - 71,314,598 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21677,444,306 - 77,444,387 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATOX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385151,742,822 - 151,758,631 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5151,742,316 - 151,772,532 (-)EnsemblGRCh38hg38GRCh38
GRCh375151,122,383 - 151,138,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365151,102,576 - 151,118,403 (-)NCBINCBI36Build 36hg18NCBI36
Build 345151,102,576 - 151,118,533NCBI
Celera5147,203,796 - 147,219,624 (-)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5146,267,764 - 146,283,598 (-)NCBIHuRef
CHM1_15150,554,807 - 150,570,651 (-)NCBICHM1_1
T2T-CHM13v2.05152,281,791 - 152,297,603 (-)NCBIT2T-CHM13v2.0
Atox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391155,337,463 - 55,352,034 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1155,337,467 - 55,352,065 (-)EnsemblGRCm39 Ensembl
GRCm381155,446,637 - 55,461,208 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1155,446,641 - 55,461,239 (-)EnsemblGRCm38mm10GRCm38
MGSCv371155,260,145 - 55,274,640 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361155,931,478 - 55,946,013 (-)NCBIMGSCv36mm8
MGSCv361155,290,066 - 55,304,561 (-)NCBIMGSCv36mm8
Cytogenetic Map11B1.3NCBI
cM Map1133.07NCBI
Atox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81040,065,525 - 40,080,627 (-)NCBIGRCr8
mRatBN7.21039,564,855 - 39,579,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,564,857 - 39,579,950 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1044,248,692 - 44,263,704 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,738,793 - 43,753,805 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01039,242,467 - 39,257,480 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,790,850 - 40,805,886 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,790,845 - 40,805,941 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01040,622,323 - 40,637,362 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41040,858,190 - 40,873,226 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11040,871,817 - 40,886,834 (-)NCBI
Celera1038,896,595 - 38,911,631 (-)NCBICelera
Cytogenetic Map10q22NCBI
Atox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554086,156,334 - 6,168,607 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554086,156,334 - 6,168,423 (-)NCBIChiLan1.0ChiLan1.0
ATOX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24146,971,589 - 146,986,802 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15145,111,134 - 145,126,336 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05147,166,744 - 147,181,970 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15153,169,467 - 153,184,505 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5153,169,467 - 153,184,505 (-)Ensemblpanpan1.1panPan2
ATOX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1457,599,927 - 57,611,863 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl457,600,005 - 57,611,862 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha457,419,665 - 57,428,499 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0458,042,538 - 58,054,372 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl458,042,619 - 58,054,371 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1457,858,631 - 57,867,491 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0457,957,162 - 57,966,028 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0458,460,492 - 58,469,405 (+)NCBIUU_Cfam_GSD_1.0
Atox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213112,512,973 - 112,558,583 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651510,962,263 - 10,977,232 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651510,962,315 - 10,982,274 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103238681
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1140,631,831 - 40,632,274 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038137,908,256 - 137,908,700 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atox1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473337,295,252 - 37,310,229 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473337,295,240 - 37,310,229 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ATOX1
734 total Variants

Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSSCT00000038847   ⟹   ENSSSCP00000050334
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1671,299,321 - 71,314,597 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000098458   ⟹   ENSSSCP00000080853
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1671,306,761 - 71,314,597 (+)Ensembl
RefSeq Acc Id: NM_001167641   ⟹   NP_001161113
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11671,299,321 - 71,314,598 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001161113   ⟸   NM_001167641
- UniProtKB: D0G0C7 (UniProtKB/TrEMBL),   A0A4X1TRH4 (UniProtKB/TrEMBL),   A0A287B262 (UniProtKB/TrEMBL),   A0A8D0VDI8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000050334   ⟸   ENSSSCT00000038847
Ensembl Acc Id: ENSSSCP00000080853   ⟸   ENSSSCT00000098458
Protein Domains
HMA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000026414 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015024725 UniProtKB/TrEMBL
  ENSSSCG00025038649 UniProtKB/TrEMBL
  ENSSSCG00030007728 UniProtKB/TrEMBL
  ENSSSCG00035009159 UniProtKB/TrEMBL
  ENSSSCG00040075634 UniProtKB/TrEMBL
  ENSSSCG00045003876 UniProtKB/TrEMBL
  ENSSSCG00050057250 UniProtKB/TrEMBL
  ENSSSCG00055015182 UniProtKB/TrEMBL
  ENSSSCG00060061208 UniProtKB/TrEMBL
  ENSSSCG00065034800 UniProtKB/TrEMBL
  ENSSSCG00070011708 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000038847 ENTREZGENE
  ENSSSCT00000038847.3 UniProtKB/TrEMBL
  ENSSSCT00000098458.1 UniProtKB/TrEMBL
  ENSSSCT00015032844.1 UniProtKB/TrEMBL
  ENSSSCT00025052590.1 UniProtKB/TrEMBL
  ENSSSCT00025052646.1 UniProtKB/TrEMBL
  ENSSSCT00030010388.1 UniProtKB/TrEMBL
  ENSSSCT00035011478.1 UniProtKB/TrEMBL
  ENSSSCT00035011482.1 UniProtKB/TrEMBL
  ENSSSCT00040104985.1 UniProtKB/TrEMBL
  ENSSSCT00045006424.1 UniProtKB/TrEMBL
  ENSSSCT00050078047.1 UniProtKB/TrEMBL
  ENSSSCT00055029972.1 UniProtKB/TrEMBL
  ENSSSCT00060083546.1 UniProtKB/TrEMBL
  ENSSSCT00065047361.1 UniProtKB/TrEMBL
  ENSSSCT00065047365.1 UniProtKB/TrEMBL
  ENSSSCT00070022834.1 UniProtKB/TrEMBL
  ENSSSCT00070022839.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.100 UniProtKB/TrEMBL
InterPro Copper_transport_ATOX1-like UniProtKB/TrEMBL
  Heavy-metal-associated_CS UniProtKB/TrEMBL
  HMA_dom UniProtKB/TrEMBL
  HMA_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:100312962 UniProtKB/TrEMBL
NCBI Gene ATOX1 ENTREZGENE
PANTHER COPPER TRANSPORT PROTEIN ATOX1 UniProtKB/TrEMBL
  COPPER TRANSPORT PROTEIN ATOX1 UniProtKB/TrEMBL
Pfam HMA UniProtKB/TrEMBL
PROSITE HMA_1 UniProtKB/TrEMBL
  HMA_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF55008 UniProtKB/TrEMBL
UniProt A0A287B262 ENTREZGENE
  A0A4X1TRH4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0IR62_PIG UniProtKB/TrEMBL
  A0A8D0VDI8 ENTREZGENE, UniProtKB/TrEMBL
  D0G0C7 ENTREZGENE, UniProtKB/TrEMBL
  I3L7P7_PIG UniProtKB/TrEMBL
UniProt Secondary A0A287B262 UniProtKB/TrEMBL
  A0A4X1TUA6 UniProtKB/TrEMBL
VGNC ID VGNC:110653 ENTREZGENE