MAPK14 (mitogen-activated protein kinase 14) - Rat Genome Database

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Gene: MAPK14 (mitogen-activated protein kinase 14) Sus scrofa
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Symbol: MAPK14
Name: mitogen-activated protein kinase 14
RGD ID: 14147421
Description: ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase activity (ortholog); INVOLVED IN angiogenesis (ortholog); cell morphogenesis (ortholog); cell surface receptor protein serine/threonine kinase signaling pathway (ortholog); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; erythropoietin signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN cytosol (ortholog); glutamatergic synapse (ortholog); INTERACTS WITH cadmium nitrate; hydrogen peroxide; lipopolysaccharide
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl731,790,877 - 31,862,031 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1731,791,398 - 31,861,544 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2736,725,706 - 36,795,314 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
bone development  (IEA)
cartilage condensation  (IEA)
cell morphogenesis  (IEA,ISO)
cell surface receptor protein serine/threonine kinase signaling pathway  (IEA,ISO)
cellular response to ionizing radiation  (IEA)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to lipoteichoic acid  (IEA)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
cellular response to UV-B  (IEA)
cellular response to vascular endothelial growth factor stimulus  (IEA)
cellular response to virus  (IEA)
chondrocyte differentiation  (IEA,ISO)
D-glucose import  (IEA,ISO)
DNA damage checkpoint signaling  (IEA,ISO)
DNA damage response  (IEA,ISO)
fatty acid oxidation  (IEA,ISO)
glucose metabolic process  (IEA,ISO)
intracellular signal transduction  (IEA)
JNK cascade  (IEA)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
MAPK cascade  (IEA)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of hippo signaling  (IEA)
osteoblast differentiation  (IEA)
osteoclast differentiation  (IEA)
p38MAPK cascade  (IEA)
peptidyl-serine phosphorylation  (ISO)
phosphorylation  (ISO)
placenta development  (IEA,ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of brown fat cell differentiation  (IEA,ISO)
positive regulation of cardiac muscle cell proliferation  (IEA,ISO)
positive regulation of cyclase activity  (ISO)
positive regulation of D-glucose import  (IEA,ISO)
positive regulation of erythrocyte differentiation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of interleukin-12 production  (IEA)
positive regulation of myoblast differentiation  (IEA)
positive regulation of myoblast fusion  (IEA)
positive regulation of myotube differentiation  (IEA)
positive regulation of protein import into nucleus  (IEA,ISO)
positive regulation of reactive oxygen species metabolic process  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
regulation of cytokine production involved in inflammatory response  (IEA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of ossification  (IEA,ISO)
regulation of synaptic membrane adhesion  (IEA)
regulation of transcription by RNA polymerase II  (IEA)
response to dietary excess  (IEA)
response to glucose  (ISO)
response to insulin  (IEA)
response to lipopolysaccharide  (IEA,ISO)
response to muramyl dipeptide  (IEA,ISO)
response to muscle stretch  (IEA,ISO)
signal transduction in response to DNA damage  (IEA)
skeletal muscle tissue development  (IEA,ISO)
stem cell differentiation  (IEA,ISO)
stress-activated MAPK cascade  (IEA,ISO)
stress-activated protein kinase signaling cascade  (IEA)
stress-induced premature senescence  (IEA)
striated muscle cell differentiation  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)
vascular endothelial growth factor receptor signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:15333638   PMID:19023183   PMID:20300568   PMID:22301074   PMID:22909062   PMID:29845299   PMID:30032202   PMID:34863954  


Genomics

Comparative Map Data
MAPK14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl731,790,877 - 31,862,031 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1731,791,398 - 31,861,544 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2736,725,706 - 36,795,314 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38636,027,808 - 36,124,214 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl636,027,752 - 36,122,511 (+)EnsemblGRCh38hg38GRCh38
GRCh37635,995,585 - 36,079,013 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36636,103,551 - 36,186,513 (+)NCBINCBI36Build 36hg18NCBI36
Build 34636,103,550 - 36,186,513NCBI
Celera637,550,014 - 37,633,560 (+)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef635,715,466 - 35,798,847 (+)NCBIHuRef
CHM1_1635,997,235 - 36,080,771 (+)NCBICHM1_1
T2T-CHM13v2.0635,848,088 - 35,944,528 (+)NCBIT2T-CHM13v2.0
Mapk14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391728,910,316 - 28,967,379 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1728,910,303 - 28,967,380 (+)EnsemblGRCm39 Ensembl
GRCm381728,691,342 - 28,748,405 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1728,691,329 - 28,748,406 (+)EnsemblGRCm38mm10GRCm38
MGSCv371728,828,287 - 28,885,350 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361728,419,034 - 28,475,994 (+)NCBIMGSCv36mm8
Celera1729,246,340 - 29,303,175 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1714.85NCBI
Mapk14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8206,751,288 - 6,812,294 (+)NCBIGRCr8
mRatBN7.2206,749,646 - 6,810,590 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl206,749,670 - 6,810,589 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx207,462,299 - 7,522,955 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0206,824,146 - 6,884,804 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,305,502 - 7,366,242 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,933,290 - 5,995,137 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,933,303 - 5,995,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,968,528 - 8,028,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4206,939,249 - 7,000,378 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1206,939,475 - 7,000,605 (+)NCBI
Celera208,305,853 - 8,366,371 (+)NCBICelera
Cytogenetic Map20p12NCBI
Mapk14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554373,838,232 - 3,884,083 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554373,836,331 - 3,884,083 (+)NCBIChiLan1.0ChiLan1.0
MAPK14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2550,493,097 - 50,588,368 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1646,363,113 - 46,457,826 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0635,586,847 - 35,683,041 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1636,788,233 - 36,871,114 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl636,788,233 - 36,871,114 (+)Ensemblpanpan1.1panPan2
MAPK14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1125,145,647 - 5,221,558 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl125,146,037 - 5,220,603 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha125,166,000 - 5,239,239 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0125,493,681 - 5,569,596 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl125,493,440 - 5,569,596 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1125,148,463 - 5,221,682 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0125,227,753 - 5,300,687 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0125,327,755 - 5,400,924 (+)NCBIUU_Cfam_GSD_1.0
Mapk14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494640,650,066 - 40,722,468 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647623,237,277 - 23,310,232 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647623,237,762 - 23,310,211 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11736,012,164 - 36,095,542 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1736,014,454 - 36,095,138 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604435,975,418 - 36,065,487 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475421,527,333 - 21,597,733 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475421,528,121 - 21,598,064 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MAPK14
1172 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000001734   ⟹   ENSSSCP00000001690
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl731,790,877 - 31,861,536 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000042455   ⟹   ENSSSCP00000055917
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl731,791,654 - 31,862,031 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000050343   ⟹   ENSSSCP00000048677
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl731,791,639 - 31,861,536 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000068003   ⟹   ENSSSCP00000072999
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl731,791,639 - 31,861,536 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000070436   ⟹   ENSSSCP00000059920
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl731,791,636 - 31,836,271 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000083687   ⟹   ENSSSCP00000064942
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl731,791,651 - 31,862,038 (+)Ensembl
RefSeq Acc Id: XM_001929490   ⟹   XP_001929525
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1731,791,401 - 31,861,544 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003356615   ⟹   XP_003356663
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1731,791,398 - 31,861,544 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013977842   ⟹   XP_013833296
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1731,791,607 - 31,858,351 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001297832
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1731,791,607 - 31,861,544 (+)NCBI
Sequence:
RefSeq Acc Id: XP_003356663   ⟸   XM_003356615
- Peptide Label: isoform X2
- UniProtKB: A0A287BHS8 (UniProtKB/TrEMBL),   A0A480WTV0 (UniProtKB/TrEMBL),   A0A4X1SWQ7 (UniProtKB/TrEMBL),   A0A8D0P9L5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_001929525   ⟸   XM_001929490
- Peptide Label: isoform X1
- UniProtKB: A0A4X1SVG2 (UniProtKB/TrEMBL),   A0A8D0P9L5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013833296   ⟸   XM_013977842
- Peptide Label: isoform X3
- UniProtKB: A0A4X1SVL1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000048677   ⟸   ENSSSCT00000050343
Ensembl Acc Id: ENSSSCP00000001690   ⟸   ENSSSCT00000001734
Ensembl Acc Id: ENSSSCP00000072999   ⟸   ENSSSCT00000068003
Ensembl Acc Id: ENSSSCP00000064942   ⟸   ENSSSCT00000083687
Ensembl Acc Id: ENSSSCP00000059920   ⟸   ENSSSCT00000070436
Ensembl Acc Id: ENSSSCP00000055917   ⟸   ENSSSCT00000042455
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001556 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015046113 UniProtKB/TrEMBL
  ENSSSCG00025006703 UniProtKB/TrEMBL
  ENSSSCG00030072927 UniProtKB/TrEMBL
  ENSSSCG00035013929 UniProtKB/TrEMBL
  ENSSSCG00040008248 UniProtKB/TrEMBL
  ENSSSCG00045031748 UniProtKB/TrEMBL
  ENSSSCG00050056755 UniProtKB/TrEMBL
  ENSSSCG00055011186 UniProtKB/TrEMBL
  ENSSSCG00060078211 UniProtKB/TrEMBL
  ENSSSCG00065035139 UniProtKB/TrEMBL
  ENSSSCG00070004370 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000001734.6 UniProtKB/TrEMBL
  ENSSSCT00000042455 ENTREZGENE
  ENSSSCT00000042455.3 UniProtKB/TrEMBL
  ENSSSCT00000050343.3 UniProtKB/TrEMBL
  ENSSSCT00000068003 ENTREZGENE
  ENSSSCT00000068003.2 UniProtKB/TrEMBL
  ENSSSCT00015067851.1 UniProtKB/TrEMBL
  ENSSSCT00015067965.1 UniProtKB/TrEMBL
  ENSSSCT00015068540.1 UniProtKB/TrEMBL
  ENSSSCT00015068659.1 UniProtKB/TrEMBL
  ENSSSCT00015068744.1 UniProtKB/TrEMBL
  ENSSSCT00025008893.1 UniProtKB/TrEMBL
  ENSSSCT00025008897.1 UniProtKB/TrEMBL
  ENSSSCT00030102142.1 UniProtKB/TrEMBL
  ENSSSCT00030102231.1 UniProtKB/TrEMBL
  ENSSSCT00035017639.1 UniProtKB/TrEMBL
  ENSSSCT00035017660.1 UniProtKB/TrEMBL
  ENSSSCT00040010840.1 UniProtKB/TrEMBL
  ENSSSCT00040010874.1 UniProtKB/TrEMBL
  ENSSSCT00045056954.1 UniProtKB/TrEMBL
  ENSSSCT00045057174.1 UniProtKB/TrEMBL
  ENSSSCT00045057274.1 UniProtKB/TrEMBL
  ENSSSCT00045057386.1 UniProtKB/TrEMBL
  ENSSSCT00050077386.1 UniProtKB/TrEMBL
  ENSSSCT00050077400.1 UniProtKB/TrEMBL
  ENSSSCT00055022069.1 UniProtKB/TrEMBL
  ENSSSCT00055022137.1 UniProtKB/TrEMBL
  ENSSSCT00060107939.1 UniProtKB/TrEMBL
  ENSSSCT00060107951.1 UniProtKB/TrEMBL
  ENSSSCT00065047876.1 UniProtKB/TrEMBL
  ENSSSCT00065047898.1 UniProtKB/TrEMBL
  ENSSSCT00070008371.1 UniProtKB/TrEMBL
  ENSSSCT00070008389.1 UniProtKB/TrEMBL
  ENSSSCT00070008417.1 UniProtKB/TrEMBL
  ENSSSCT00070008425.1 UniProtKB/TrEMBL
  ENSSSCT00070008441.1 UniProtKB/TrEMBL
  ENSSSCT00070008446.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAP_kinase UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/TrEMBL
  MAPK_p38-like UniProtKB/TrEMBL
  p38alpha UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
KEGG Report ssc:100156630 UniProtKB/TrEMBL
NCBI Gene MAPK14 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE 14 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PRINTS P38MAPKINASE UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287AX01_PIG UniProtKB/TrEMBL
  A0A287BHS8 ENTREZGENE, UniProtKB/TrEMBL
  A0A480WTV0 ENTREZGENE
  A0A4X1SVG2 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SVL1 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SWQ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SWW5_PIG UniProtKB/TrEMBL
  A0A4X1SX27_PIG UniProtKB/TrEMBL
  A0A4X1SXA0_PIG UniProtKB/TrEMBL
  A0A5G2R9K2_PIG UniProtKB/TrEMBL
  A0A8D0P9L5 ENTREZGENE, UniProtKB/TrEMBL
  F1RYA1_PIG UniProtKB/TrEMBL
UniProt Secondary A0A480WTV0 UniProtKB/TrEMBL
VGNC ID VGNC:90000 ENTREZGENE