SLC22A1 (solute carrier family 22 member 1) - Rat Genome Database

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Gene: SLC22A1 (solute carrier family 22 member 1) Sus scrofa
Analyze
Symbol: SLC22A1
Name: solute carrier family 22 member 1
RGD ID: 14139896
Description: ENCODES a protein that exhibits (R)-carnitine transmembrane transporter activity (ortholog); acetylcholine transmembrane transporter activity (ortholog); dopamine:sodium symporter activity (ortholog); INVOLVED IN (R)-carnitine transmembrane transport (ortholog); acetylcholine transport (ortholog); dopamine transport (ortholog); PARTICIPATES IN lamivudine pharmacokinetics pathway; metformin pharmacokinetics pathway; tramadol pharmacokinetics pathway; ASSOCIATED WITH 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (ortholog); acute kidney failure (ortholog); asthma (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: OCT1; organic cation transporter 1; pOCT1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,340,126 - 7,365,520 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,340,442 - 7,365,543 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,139,435 - 9,164,369 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SLC22A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,340,126 - 7,365,520 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,340,442 - 7,365,543 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,139,435 - 9,164,369 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386160,121,815 - 160,158,718 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6160,121,815 - 160,158,718 (+)EnsemblGRCh38hg38GRCh38
GRCh376160,542,847 - 160,579,750 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,462,853 - 160,499,740 (+)NCBINCBI36Build 36hg18NCBI36
Build 346160,513,273 - 160,550,159NCBI
Celera6161,188,634 - 161,224,539 (+)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6158,013,550 - 158,049,540 (+)NCBIHuRef
CHM1_16160,805,108 - 160,841,995 (+)NCBICHM1_1
T2T-CHM13v2.06161,367,910 - 161,404,908 (+)NCBIT2T-CHM13v2.0
Slc22a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391712,867,761 - 12,894,725 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1712,867,756 - 12,894,716 (-)EnsemblGRCm39 Ensembl
GRCm381712,648,874 - 12,675,838 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,648,869 - 12,675,829 (-)EnsemblGRCm38mm10GRCm38
MGSCv371712,841,740 - 12,868,704 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,492,232 - 12,519,196 (-)NCBIMGSCv36mm8
Celera1712,680,587 - 12,707,864 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.63NCBI
Slc22a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,624,339 - 50,651,437 (+)NCBIGRCr8
mRatBN7.2148,076,657 - 48,103,679 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,076,666 - 48,103,678 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,768,287 - 48,795,288 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,754,091 - 54,781,071 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,843,810 - 48,870,799 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,273,639 - 48,300,645 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,273,611 - 48,300,655 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,452,604 - 51,479,610 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,351,239 - 42,378,295 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,354,183 - 42,381,239 (+)NCBI
Celera143,876,335 - 43,903,290 (+)NCBICelera
Cytogenetic Map1q11NCBI
SLC22A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25180,216,337 - 180,263,051 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16178,125,295 - 178,169,671 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06158,004,545 - 158,046,428 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16163,014,522 - 163,054,818 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6163,014,663 - 163,054,681 (+)Ensemblpanpan1.1panPan2
SLC22A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,268,978 - 49,296,522 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha150,109,085 - 50,138,635 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,451,887 - 49,481,466 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,451,182 - 49,482,182 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,334,247 - 49,363,803 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0149,205,883 - 49,235,453 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0149,820,796 - 49,850,348 (+)NCBIUU_Cfam_GSD_1.0
Slc22a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946144,281,749 - 144,305,075 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,534,095 - 11,556,745 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648911,534,095 - 11,556,759 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,744,600 - 87,780,846 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1387,745,023 - 87,781,073 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604060,132,123 - 60,167,647 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in SLC22A1
748 total Variants

Expression

RNA-SEQ Expression

mesenchyme
renal system
2 2

Sequence


Ensembl Acc Id: ENSSSCT00000004469   ⟹   ENSSSCP00000004367
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl17,340,126 - 7,365,510 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000024677   ⟹   ENSSSCP00000025828
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl17,340,450 - 7,365,520 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000046271   ⟹   ENSSSCP00000040595
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl17,340,126 - 7,365,510 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000086622   ⟹   ENSSSCP00000067372
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl17,340,450 - 7,365,464 (-)Ensembl
RefSeq Acc Id: NM_001348975   ⟹   NP_001335904
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.117,340,442 - 7,365,529 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021082548   ⟹   XP_020938207
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.117,340,442 - 7,365,543 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020938207   ⟸   XM_021082548
- Peptide Label: isoform X1
- UniProtKB: A0A4X1VQK6 (UniProtKB/TrEMBL),   I3LP03 (UniProtKB/TrEMBL),   A0A8D0SAT3 (UniProtKB/TrEMBL),   A0A8D1JT65 (UniProtKB/TrEMBL),   A0A8D1Z1N4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001335904   ⟸   NM_001348975
- UniProtKB: A0A287A9U9 (UniProtKB/TrEMBL),   A0A4X1VX46 (UniProtKB/TrEMBL),   A0A8D0S3G7 (UniProtKB/TrEMBL),   A0A8D1LCP1 (UniProtKB/TrEMBL),   A0A8D1Z261 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000025828   ⟸   ENSSSCT00000024677
Ensembl Acc Id: ENSSSCP00000067372   ⟸   ENSSSCT00000086622
Ensembl Acc Id: ENSSSCP00000040595   ⟸   ENSSSCT00000046271
Ensembl Acc Id: ENSSSCP00000004367   ⟸   ENSSSCT00000004469
Protein Domains
Major facilitator superfamily (MFS) profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004041 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015038648 UniProtKB/TrEMBL
  ENSSSCG00025045120 UniProtKB/TrEMBL
  ENSSSCG00030051155 UniProtKB/TrEMBL
  ENSSSCG00035061401 UniProtKB/TrEMBL
  ENSSSCG00040015218 UniProtKB/TrEMBL
  ENSSSCG00045016977 UniProtKB/TrEMBL
  ENSSSCG00050003566 UniProtKB/TrEMBL
  ENSSSCG00055017215 UniProtKB/TrEMBL
  ENSSSCG00065048350 UniProtKB/TrEMBL
  ENSSSCG00070026972 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000004469.5 UniProtKB/TrEMBL
  ENSSSCT00000024677 ENTREZGENE
  ENSSSCT00000024677.4 UniProtKB/TrEMBL
  ENSSSCT00000046271 ENTREZGENE
  ENSSSCT00000046271.3 UniProtKB/TrEMBL
  ENSSSCT00000086622.2 UniProtKB/TrEMBL
  ENSSSCT00015051398.1 UniProtKB/TrEMBL
  ENSSSCT00015051540.1 UniProtKB/TrEMBL
  ENSSSCT00015051623.1 UniProtKB/TrEMBL
  ENSSSCT00015051744.1 UniProtKB/TrEMBL
  ENSSSCT00025061252.1 UniProtKB/TrEMBL
  ENSSSCT00025061440.1 UniProtKB/TrEMBL
  ENSSSCT00030071287.1 UniProtKB/TrEMBL
  ENSSSCT00030071302.1 UniProtKB/TrEMBL
  ENSSSCT00030071338.1 UniProtKB/TrEMBL
  ENSSSCT00035082490.1 UniProtKB/TrEMBL
  ENSSSCT00035082503.1 UniProtKB/TrEMBL
  ENSSSCT00035082517.1 UniProtKB/TrEMBL
  ENSSSCT00040020490.1 UniProtKB/TrEMBL
  ENSSSCT00040020509.1 UniProtKB/TrEMBL
  ENSSSCT00040020541.1 UniProtKB/TrEMBL
  ENSSSCT00045028905.1 UniProtKB/TrEMBL
  ENSSSCT00045028999.1 UniProtKB/TrEMBL
  ENSSSCT00050004895.1 UniProtKB/TrEMBL
  ENSSSCT00050004935.1 UniProtKB/TrEMBL
  ENSSSCT00055033901.1 UniProtKB/TrEMBL
  ENSSSCT00055034019.1 UniProtKB/TrEMBL
  ENSSSCT00055034144.1 UniProtKB/TrEMBL
  ENSSSCT00065066126.1 UniProtKB/TrEMBL
  ENSSSCT00065066142.1 UniProtKB/TrEMBL
  ENSSSCT00065066152.1 UniProtKB/TrEMBL
  ENSSSCT00070054093.1 UniProtKB/TrEMBL
  ENSSSCT00070054095.1 UniProtKB/TrEMBL
  ENSSSCT00070054096.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MFS UniProtKB/TrEMBL
  MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_sugar_transport-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orgcat_transp/SVOP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/TrEMBL
NCBI Gene SLC22A1 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 22 MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/TrEMBL
  Sugar_tr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR_TRANSPORT_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287A9U9 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VQK6 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VW63_PIG UniProtKB/TrEMBL
  A0A4X1VX46 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QR27_PIG UniProtKB/TrEMBL
  A0A8D0NKI6_PIG UniProtKB/TrEMBL
  A0A8D0NLB8_PIG UniProtKB/TrEMBL
  A0A8D0NQS2_PIG UniProtKB/TrEMBL
  A0A8D0S3G7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0SAT3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0U2W4_PIG UniProtKB/TrEMBL
  A0A8D0X501_PIG UniProtKB/TrEMBL
  A0A8D0X8J1_PIG UniProtKB/TrEMBL
  A0A8D0X9D7_PIG UniProtKB/TrEMBL
  A0A8D1DKH7_PIG UniProtKB/TrEMBL
  A0A8D1DKW8_PIG UniProtKB/TrEMBL
  A0A8D1DLN1_PIG UniProtKB/TrEMBL
  A0A8D1HIW7_PIG UniProtKB/TrEMBL
  A0A8D1JT65 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1KXA6_PIG UniProtKB/TrEMBL
  A0A8D1LCP1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1U4T9_PIG UniProtKB/TrEMBL
  A0A8D1YY17_PIG UniProtKB/TrEMBL
  A0A8D1Z1N4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1Z261 ENTREZGENE, UniProtKB/TrEMBL
  F1SB78_PIG UniProtKB/TrEMBL
  I3LP03 ENTREZGENE, UniProtKB/TrEMBL
  Q863T6 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:103179 ENTREZGENE