PMP22 (peripheral myelin protein 22) - Rat Genome Database

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Gene: PMP22 (peripheral myelin protein 22) Sus scrofa
Analyze
Symbol: PMP22
Name: peripheral myelin protein 22
RGD ID: 14136849
Description: ENCODES a protein that exhibits cytoskeletal motor activity (ortholog); protein serine/threonine kinase inhibitor activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); adult locomotory behavior (ortholog); adult walking behavior (ortholog); ASSOCIATED WITH Abnormal Reflexes (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN bicellular tight junction (ortholog); cell surface (ortholog); compact myelin (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1258,679,775 - 58,707,925 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11258,679,773 - 58,734,195 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
adult locomotory behavior  (ISO)
adult walking behavior  (ISO)
aggresome assembly  (ISO)
apoptotic process  (IEA)
autophagy  (ISO)
axon development  (ISO)
basement membrane organization  (ISO)
bleb assembly  (IEA)
cell adhesion  (ISO)
cell differentiation  (ISO)
cellular response to heat  (ISO)
cellular response to unfolded protein  (ISO)
cholesterol metabolic process  (ISO)
fibroblast migration  (ISO)
gliogenesis  (ISO)
immune response  (ISO)
lamellipodium assembly  (ISO)
lipid metabolic process  (ISO)
mating  (ISO)
membrane raft organization  (ISO)
motor behavior  (ISO)
multicellular organism growth  (ISO)
muscle cell development  (ISO)
myelin assembly  (IBA,ISO)
myelination  (ISO)
myelination in peripheral nervous system  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of neuron projection development  (ISO)
neuromuscular junction development, skeletal muscle fiber  (ISO)
neuromuscular process  (ISO)
neuronal action potential  (ISO)
neuronal action potential propagation  (ISO)
neuronal ion channel clustering  (ISO)
paranodal junction assembly  (ISO)
peripheral nervous system development  (ISO)
peripheral nervous system neuron axonogenesis  (ISO)
positive regulation of gene expression  (ISO)
proteasomal protein catabolic process  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
regulation of apoptotic signaling pathway  (ISO)
regulation of gene expression  (ISO)
regulation of glial cell apoptotic process  (ISO)
regulation of inflammatory response  (ISO)
regulation of Schwann cell proliferation  (ISO)
response to bacterium  (ISO)
response to endoplasmic reticulum stress  (ISO)
Schwann cell development  (ISO)
Schwann cell differentiation  (ISO)
Schwann cell migration  (ISO)
striated muscle cell differentiation  (ISO)
transmission of nerve impulse  (ISO)
vestibular reflex  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:30032202  


Genomics

Comparative Map Data
PMP22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1258,679,775 - 58,707,925 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11258,679,773 - 58,734,195 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PMP22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381715,229,779 - 15,265,326 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1715,229,773 - 15,272,292 (-)EnsemblGRCh38hg38GRCh38
GRCh371715,133,096 - 15,168,643 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361715,073,821 - 15,109,369 (-)NCBINCBI36Build 36hg18NCBI36
Build 341715,073,821 - 15,104,818NCBI
Celera1715,157,676 - 15,193,224 (-)NCBICelera
Cytogenetic Map17p12NCBI
HuRef1715,027,217 - 15,062,782 (-)NCBIHuRef
CHM1_11715,141,853 - 15,177,435 (-)NCBICHM1_1
T2T-CHM13v2.01715,135,787 - 15,171,333 (-)NCBIT2T-CHM13v2.0
Pmp22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391163,019,808 - 63,050,373 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1163,019,808 - 63,050,373 (+)EnsemblGRCm39 Ensembl
GRCm381163,128,982 - 63,159,547 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1163,128,982 - 63,159,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv371162,945,012 - 62,973,048 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361162,947,705 - 62,975,741 (+)NCBIMGSCv36mm8
Celera1170,064,333 - 70,092,386 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1138.99NCBI
Pmp22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81048,294,932 - 48,324,941 (+)NCBIGRCr8
mRatBN7.21047,795,709 - 47,825,715 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1047,795,709 - 47,825,714 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1052,499,025 - 52,528,991 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01051,989,555 - 52,019,509 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01047,492,979 - 47,522,935 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01049,538,588 - 49,568,583 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1049,538,588 - 49,568,583 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01049,317,000 - 49,346,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41049,305,835 - 49,335,864 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11049,319,457 - 49,349,487 (+)NCBI
Celera1047,038,544 - 47,068,443 (+)NCBICelera
Cytogenetic Map10q23NCBI
Pmp22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554672,423,659 - 2,457,307 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554672,422,181 - 2,456,925 (+)NCBIChiLan1.0ChiLan1.0
PMP22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21958,488,213 - 58,523,897 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11763,294,798 - 63,330,410 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01736,389,549 - 36,425,161 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11741,038,286 - 41,073,872 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1741,038,302 - 41,073,872 (+)Ensemblpanpan1.1panPan2
PMP22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1538,806,731 - 38,839,002 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl538,807,826 - 38,838,971 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha538,951,486 - 38,983,753 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0538,914,812 - 38,947,091 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl538,914,813 - 38,947,074 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1538,887,774 - 38,920,037 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0538,833,093 - 38,865,352 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0539,021,339 - 39,053,622 (-)NCBIUU_Cfam_GSD_1.0
Pmp22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560257,777,101 - 57,810,336 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367241,747,005 - 1,778,141 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367241,747,015 - 1,780,298 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PMP22
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11614,527,892 - 14,563,223 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1614,527,672 - 14,563,171 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660596,655,072 - 6,690,713 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pmp22
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248773,292,244 - 3,328,660 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248773,293,980 - 3,328,337 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PMP22
1347 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000045217   ⟹   ENSSSCP00000041599
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1258,679,779 - 58,695,363 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000054126   ⟹   ENSSSCP00000040961
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1258,685,819 - 58,707,925 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000086442   ⟹   ENSSSCP00000066268
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1258,685,308 - 58,707,925 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000087039   ⟹   ENSSSCP00000072703
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1258,688,836 - 58,707,925 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000097632   ⟹   ENSSSCP00000079108
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1258,680,920 - 58,707,925 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000103415   ⟹   ENSSSCP00000080665
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1258,679,775 - 58,707,925 (-)Ensembl
RefSeq Acc Id: XM_021067894   ⟹   XP_020923553
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11258,679,773 - 58,706,024 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021067895   ⟹   XP_020923554
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11258,679,773 - 58,707,967 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021067896   ⟹   XP_020923555
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11258,679,773 - 58,734,195 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021067897   ⟹   XP_020923556
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11258,679,773 - 58,705,408 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020923555   ⟸   XM_021067896
- UniProtKB: A0A480F3W3 (UniProtKB/TrEMBL),   A0A4X1SPQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020923554   ⟸   XM_021067895
- UniProtKB: A0A480F3W3 (UniProtKB/TrEMBL),   A0A4X1SPQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020923553   ⟸   XM_021067894
- UniProtKB: A0A480F3W3 (UniProtKB/TrEMBL),   A0A4X1SPQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020923556   ⟸   XM_021067897
- UniProtKB: A0A480F3W3 (UniProtKB/TrEMBL),   A0A4X1SPQ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000040961   ⟸   ENSSSCT00000054126
Ensembl Acc Id: ENSSSCP00000041599   ⟸   ENSSSCT00000045217
Ensembl Acc Id: ENSSSCP00000066268   ⟸   ENSSSCT00000086442
Ensembl Acc Id: ENSSSCP00000072703   ⟸   ENSSSCT00000087039
Ensembl Acc Id: ENSSSCP00000079108   ⟸   ENSSSCT00000097632
Ensembl Acc Id: ENSSSCP00000080665   ⟸   ENSSSCT00000103415


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000037832 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025049749 UniProtKB/TrEMBL
  ENSSSCG00030021446 UniProtKB/TrEMBL
  ENSSSCG00035060576 UniProtKB/TrEMBL
  ENSSSCG00040035500 UniProtKB/TrEMBL
  ENSSSCG00045025168 UniProtKB/TrEMBL
  ENSSSCG00050078245 UniProtKB/TrEMBL
  ENSSSCG00055002786 UniProtKB/TrEMBL
  ENSSSCG00060076993 UniProtKB/TrEMBL
  ENSSSCG00065026630 UniProtKB/TrEMBL
  ENSSSCG00070002996 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000045217.3 UniProtKB/TrEMBL
  ENSSSCT00000086442.1 UniProtKB/TrEMBL
  ENSSSCT00000087039.1 UniProtKB/TrEMBL
  ENSSSCT00000097632.1 UniProtKB/TrEMBL
  ENSSSCT00000103415 ENTREZGENE
  ENSSSCT00000103415.1 UniProtKB/TrEMBL
  ENSSSCT00025067966.1 UniProtKB/TrEMBL
  ENSSSCT00030029775.1 UniProtKB/TrEMBL
  ENSSSCT00035081299.1 UniProtKB/TrEMBL
  ENSSSCT00040047791.1 UniProtKB/TrEMBL
  ENSSSCT00045043026.1 UniProtKB/TrEMBL
  ENSSSCT00050107861.1 UniProtKB/TrEMBL
  ENSSSCT00055005357.1 UniProtKB/TrEMBL
  ENSSSCT00060105863.1 UniProtKB/TrEMBL
  ENSSSCT00065035824.1 UniProtKB/TrEMBL
  ENSSSCT00070005633.1 UniProtKB/TrEMBL
  ENSSSCT00070005639.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.140.150 UniProtKB/TrEMBL
InterPro PMP-22/EMP/MP20 UniProtKB/TrEMBL
  PMP22 UniProtKB/TrEMBL
  PMP22/EMP/MP20/Claudin UniProtKB/TrEMBL
  PMP22_EMP_MP20 UniProtKB/TrEMBL
NCBI Gene PMP22 ENTREZGENE
PANTHER EPITHELIAL MEMBRANE PROTEIN-RELATED UniProtKB/TrEMBL
  PTHR10671:SF7 UniProtKB/TrEMBL
Pfam PMP22_Claudin UniProtKB/TrEMBL
PRINTS EPMEMFAMILY UniProtKB/TrEMBL
  PMYELIN22 UniProtKB/TrEMBL
PROSITE PMP22_1 UniProtKB/TrEMBL
  PMP22_2 UniProtKB/TrEMBL
UniProt A0A287AC58_PIG UniProtKB/TrEMBL
  A0A480F3W3 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SPL0_PIG UniProtKB/TrEMBL
  A0A4X1SPQ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QWF4_PIG UniProtKB/TrEMBL
  A0A5G2R8R2_PIG UniProtKB/TrEMBL
  A0A8W4FJN1_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91590 ENTREZGENE