GJA5 (gap junction protein alpha 5) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: GJA5 (gap junction protein alpha 5) Sus scrofa
Analyze
Symbol: GJA5
Name: gap junction protein alpha 5
RGD ID: 14068516
Description: ENCODES a protein that exhibits connexin binding (ortholog); disordered domain specific binding (ortholog); gap junction channel activity (ortholog); INVOLVED IN cellular response to platelet-derived growth factor stimulus; artery morphogenesis (ortholog); atrial septum morphogenesis (ortholog); PARTICIPATES IN connexin signaling pathway; ASSOCIATED WITH atrial fibrillation (ortholog); atrial standstill 1 (ortholog); autism spectrum disorder (ortholog); FOUND IN cell projection (ortholog); connexin complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: gap junction alpha-5 protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,854,392 - 99,871,286 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1499,854,129 - 99,871,288 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24109,687,517 - 109,704,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
artery morphogenesis  (ISO)
atrial cardiac muscle cell to AV node cell communication by electrical coupling  (IBA,IEA)
atrial septum development  (IEA)
atrial septum morphogenesis  (ISO)
atrial ventricular junction remodeling  (ISO)
AV node cell to bundle of His cell communication  (ISO)
AV node cell to bundle of His cell communication by electrical coupling  (IEA)
blood vessel development  (ISO)
blood vessel diameter maintenance  (ISO)
bundle of His cell to Purkinje myocyte communication by electrical coupling  (IEA)
cardiac conduction  (ISO)
cardiac conduction system development  (ISO)
cell communication  (IEA)
cell communication by chemical coupling  (ISO)
cell communication by electrical coupling  (ISO)
cell communication by electrical coupling involved in cardiac conduction  (IEA,ISO)
cell communication involved in cardiac conduction  (ISO)
cell-cell signaling  (IBA)
cellular response to platelet-derived growth factor stimulus  (IDA)
embryonic heart tube development  (ISO)
embryonic limb morphogenesis  (ISO)
endothelium development  (ISO)
foramen ovale closure  (ISO)
gap junction assembly  (IEA)
heart development  (IBA,ISO)
mitral valve development  (IEA)
negative regulation of blood pressure  (ISO)
negative regulation of glomerular filtration  (ISO)
outflow tract morphogenesis  (IEA)
positive regulation of cell communication by chemical coupling  (ISO)
positive regulation of vasoconstriction  (ISO)
potassium ion transport  (ISO)
pulmonary valve formation  (IEA)
regulation of atrial cardiac muscle cell action potential  (IEA)
regulation of atrial cardiac muscle cell membrane depolarization  (IEA,ISO)
regulation of AV node cell action potential  (IEA)
regulation of bundle of His cell action potential  (IEA)
regulation of cardiac muscle contraction  (IEA)
regulation of cell communication by electrical coupling  (ISO)
regulation of heart rate by cardiac conduction  (ISO)
regulation of membrane depolarization during cardiac muscle cell action potential  (ISO)
regulation of Purkinje myocyte action potential  (IEA)
regulation of renin secretion into blood stream  (ISO)
regulation of systemic arterial blood pressure  (ISO)
regulation of ventricular cardiac muscle cell membrane depolarization  (ISO)
regulation of ventricular cardiac muscle cell membrane repolarization  (ISO)
renal system process involved in regulation of systemic arterial blood pressure  (ISO)
SA node cell action potential  (ISO)
septum primum development  (ISO)
skeletal system development  (ISO)
transmembrane transport  (IEA)
vasodilation  (ISO)
vasomotion  (ISO)
ventricular cardiac muscle cell action potential  (ISO)
ventricular septum development  (IEA)
ventricular septum morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GJA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,854,392 - 99,871,286 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1499,854,129 - 99,871,288 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24109,687,517 - 109,704,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GJA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,756,199 - 147,773,351 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,756,199 - 147,773,362 (-)EnsemblGRCh38hg38GRCh38
GRCh371147,228,332 - 147,245,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361145,694,956 - 145,712,108 (-)NCBINCBI36Build 36hg18NCBI36
Build 341144,453,708 - 144,457,501NCBI
Celera1121,738,476 - 121,755,641 (+)NCBICelera
Cytogenetic Map1q21.2NCBI
HuRef1120,641,850 - 120,658,997 (-)NCBIHuRef
CHM1_11149,124,325 - 149,141,488 (-)NCBICHM1_1
T2T-CHM13v2.01147,034,309 - 147,051,468 (+)NCBIT2T-CHM13v2.0
Gja5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,939,718 - 96,960,950 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,812,009 - 96,984,732 (+)EnsemblGRCm39 Ensembl
GRCm38397,032,402 - 97,053,634 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,904,693 - 97,077,416 (+)EnsemblGRCm38mm10GRCm38
MGSCv37396,836,339 - 96,857,557 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36397,117,821 - 97,139,039 (+)NCBIMGSCv36mm8
Celera398,439,607 - 98,460,828 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map342.04NCBI
Gja5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82187,291,227 - 187,310,770 (+)NCBIGRCr8
mRatBN7.22184,602,407 - 184,621,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2184,564,475 - 184,621,952 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2192,244,465 - 192,263,988 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02190,042,684 - 190,062,193 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02184,877,034 - 184,896,564 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02199,162,745 - 199,184,942 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2199,162,745 - 199,184,939 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02218,648,368 - 218,669,354 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,824,118 - 191,843,867 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12191,786,871 - 191,806,619 (+)NCBI
Celera2177,098,223 - 177,117,685 (+)NCBICelera
Cytogenetic Map2q34NCBI
Gja5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955568635,042 - 653,349 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955568635,319 - 652,692 (+)NCBIChiLan1.0ChiLan1.0
GJA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21101,927,011 - 101,952,954 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11101,515,393 - 101,539,948 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01123,200,111 - 123,224,626 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11112,306,880 - 112,331,358 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1112,328,337 - 112,329,413 (+)Ensemblpanpan1.1panPan2
GJA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11758,289,327 - 58,305,315 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1758,289,327 - 58,305,315 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1757,757,715 - 57,773,685 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01759,286,062 - 59,301,971 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1759,285,495 - 59,302,023 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11758,159,018 - 58,175,010 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01758,219,654 - 58,235,621 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01758,946,248 - 58,962,243 (-)NCBIUU_Cfam_GSD_1.0
Gja5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505820,393,289 - 20,403,471 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936867269,477 - 279,549 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603814,460,790 - 14,478,590 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gja5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477216,813,011 - 16,814,084 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477216,810,723 - 16,828,328 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GJA5
512 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 19 1 5 14 12 19 3 4 1

Sequence


Ensembl Acc Id: ENSSSCT00000007335   ⟹   ENSSSCP00000007140
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl499,854,392 - 99,871,286 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000085228   ⟹   ENSSSCP00000065635
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl499,854,392 - 99,871,285 (+)Ensembl
RefSeq Acc Id: XM_001928300   ⟹   XP_001928335
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1499,854,138 - 99,871,288 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005653068   ⟹   XP_005653125
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1499,854,129 - 99,871,288 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013993317   ⟹   XP_013848771
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1499,854,129 - 99,871,288 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005653125   ⟸   XM_005653068
- UniProtKB: A0A4X1SLG1 (UniProtKB/TrEMBL),   A0A8D0PC11 (UniProtKB/TrEMBL),   F1SDC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013848771   ⟸   XM_013993317
- UniProtKB: A0A4X1SLG1 (UniProtKB/TrEMBL),   A0A8D0PC11 (UniProtKB/TrEMBL),   F1SDC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_001928335   ⟸   XM_001928300
- UniProtKB: A0A4X1SLG1 (UniProtKB/TrEMBL),   A0A8D0PC11 (UniProtKB/TrEMBL),   F1SDC3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000065635   ⟸   ENSSSCT00000085228
Ensembl Acc Id: ENSSSCP00000007140   ⟸   ENSSSCT00000007335
Protein Domains
Connexin N-terminal   Gap junction protein cysteine-rich


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006696 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015059816 UniProtKB/TrEMBL
  ENSSSCG00025062004 UniProtKB/TrEMBL
  ENSSSCG00030072671 UniProtKB/TrEMBL
  ENSSSCG00035074850 UniProtKB/TrEMBL
  ENSSSCG00040044693 UniProtKB/TrEMBL
  ENSSSCG00045026310 UniProtKB/TrEMBL
  ENSSSCG00050005847 UniProtKB/TrEMBL
  ENSSSCG00055029612 UniProtKB/TrEMBL
  ENSSSCG00060032506 UniProtKB/TrEMBL
  ENSSSCG00065002835 UniProtKB/TrEMBL
  ENSSSCG00070002140 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000007335 ENTREZGENE
  ENSSSCT00000007335.5 UniProtKB/TrEMBL
  ENSSSCT00000085228.1 UniProtKB/TrEMBL
  ENSSSCT00015079841.1 UniProtKB/TrEMBL
  ENSSSCT00015079921.1 UniProtKB/TrEMBL
  ENSSSCT00025084874.1 UniProtKB/TrEMBL
  ENSSSCT00025084929.1 UniProtKB/TrEMBL
  ENSSSCT00030101747.1 UniProtKB/TrEMBL
  ENSSSCT00030101758.1 UniProtKB/TrEMBL
  ENSSSCT00035101702.1 UniProtKB/TrEMBL
  ENSSSCT00035101710.1 UniProtKB/TrEMBL
  ENSSSCT00040059923.1 UniProtKB/TrEMBL
  ENSSSCT00040059952.1 UniProtKB/TrEMBL
  ENSSSCT00045044747.1 UniProtKB/TrEMBL
  ENSSSCT00045044769.1 UniProtKB/TrEMBL
  ENSSSCT00050007939.1 UniProtKB/TrEMBL
  ENSSSCT00050007944.1 UniProtKB/TrEMBL
  ENSSSCT00055058830.1 UniProtKB/TrEMBL
  ENSSSCT00055058839.1 UniProtKB/TrEMBL
  ENSSSCT00060044013.1 UniProtKB/TrEMBL
  ENSSSCT00060044015.1 UniProtKB/TrEMBL
  ENSSSCT00065003667.1 UniProtKB/TrEMBL
  ENSSSCT00065003673.1 UniProtKB/TrEMBL
  ENSSSCT00070003980.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1440.80 UniProtKB/TrEMBL
InterPro Connexin UniProtKB/TrEMBL
  Connexin40 UniProtKB/TrEMBL
  Connexin_C UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/TrEMBL
  Connexin_CS UniProtKB/TrEMBL
  Connexin_N UniProtKB/TrEMBL
  Connexin_N_sf UniProtKB/TrEMBL
  Cx40_C UniProtKB/TrEMBL
KEGG Report ssc:100157795 UniProtKB/TrEMBL
NCBI Gene GJA5 ENTREZGENE
PANTHER PTHR11984 UniProtKB/TrEMBL
  PTHR11984:SF13 UniProtKB/TrEMBL
Pfam Connexin UniProtKB/TrEMBL
  Connexin40_C UniProtKB/TrEMBL
PRINTS CONNEXIN UniProtKB/TrEMBL
  CONNEXINA5 UniProtKB/TrEMBL
PROSITE CONNEXINS_1 UniProtKB/TrEMBL
  CONNEXINS_2 UniProtKB/TrEMBL
SMART CNX UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/TrEMBL
Superfamily-SCOP SSF118220 UniProtKB/TrEMBL
UniProt A0A4X1SLG1 ENTREZGENE
  A0A8D0PC11 ENTREZGENE, UniProtKB/TrEMBL
  F1SDC3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A4X1SLG1 UniProtKB/TrEMBL
VGNC ID VGNC:88460 ENTREZGENE