NTRK3 (neurotrophic receptor tyrosine kinase 3) - Rat Genome Database

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Gene: NTRK3 (neurotrophic receptor tyrosine kinase 3) Sus scrofa
Analyze
Symbol: NTRK3
Name: neurotrophic receptor tyrosine kinase 3
RGD ID: 14067959
Description: ENCODES a protein that exhibits GPI-linked ephrin receptor activity (ortholog); INVOLVED IN cellular response to retinoic acid (ortholog); cochlea development (ortholog); heart development (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); adenoid cystic carcinoma (ortholog); Alcohol-Related Disorders (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic membrane (ortholog); INTERACTS WITH zearalenone
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: gp145-trkC; neurotrophic tyrosine kinase, receptor, type 3; NT-3 growth factor receptor; trk-C; TRKC; trkC tyrosine kinase; tyrosine kinase receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1191,535,301 - 191,925,327 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11191,535,262 - 191,941,675 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21212,938,371 - 213,258,768 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon extension involved in regeneration  (IEA)
cell communication  (IEA)
cell differentiation  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IBA,IEA)
cellular response to nerve growth factor stimulus  (IBA)
cellular response to retinoic acid  (ISO)
circadian rhythm  (IEA)
cochlea development  (ISO)
heart development  (IEA,ISS)
lens fiber cell differentiation  (IEA)
mechanoreceptor differentiation  (IEA)
myelination in peripheral nervous system  (IEA)
negative regulation of astrocyte differentiation  (ISO)
nervous system development  (IEA)
neuron fate specification  (ISO)
neuron migration  (ISO)
neuronal action potential propagation  (IEA)
neurotrophin signaling pathway  (IEA)
positive regulation of apoptotic process  (IEA)
positive regulation of axon extension involved in regeneration  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of MAPK cascade  (IEA)
positive regulation of neuron projection development  (IBA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA,IEA)
positive regulation of positive chemotaxis  (IEA)
positive regulation of synapse assembly  (IEA)
postsynaptic density assembly  (ISO)
regulation of neural precursor cell proliferation  (ISO)
regulation of presynapse assembly  (ISO)
response to axon injury  (ISO)
response to corticosterone  (ISO)
response to ethanol  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:1653651   PMID:14681463   PMID:17407547   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NTRK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1191,535,301 - 191,925,327 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11191,535,262 - 191,941,675 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21212,938,371 - 213,258,768 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NTRK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381587,859,751 - 88,256,739 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1587,859,751 - 88,256,791 (-)EnsemblGRCh38hg38GRCh38
GRCh371588,402,982 - 88,799,970 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361586,220,992 - 86,600,665 (-)NCBINCBI36Build 36hg18NCBI36
Build 341586,220,991 - 86,600,665NCBI
Celera1564,821,267 - 65,200,916 (-)NCBICelera
Cytogenetic Map15q25.3NCBI
HuRef1564,532,241 - 64,911,404 (-)NCBIHuRef
CHM1_11588,261,800 - 88,641,816 (-)NCBICHM1_1
T2T-CHM13v2.01585,614,323 - 86,011,407 (-)NCBIT2T-CHM13v2.0
Ntrk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39777,825,711 - 78,228,865 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl777,825,707 - 78,387,760 (-)EnsemblGRCm39 Ensembl
GRCm38778,179,986 - 78,581,034 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl778,175,959 - 78,738,012 (-)EnsemblGRCm38mm10GRCm38
MGSCv37785,337,000 - 85,722,724 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36778,066,072 - 78,451,488 (-)NCBIMGSCv36mm8
Celera775,610,791 - 75,991,488 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map744.01NCBI
Ntrk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81141,526,192 - 141,913,575 (-)NCBIGRCr8
mRatBN7.21132,116,472 - 132,503,849 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1132,132,849 - 132,503,286 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1140,038,778 - 140,410,193 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01147,208,513 - 147,579,935 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01140,126,320 - 140,497,270 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01139,890,537 - 140,262,503 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1139,890,560 - 140,262,503 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01140,868,261 - 141,239,954 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41133,925,530 - 134,302,139 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11134,003,872 - 134,380,482 (-)NCBI
Celera1124,206,109 - 124,576,015 (-)NCBICelera
Cytogenetic Map1q31NCBI
Ntrk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541616,652,791 - 17,018,188 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541616,652,931 - 17,018,188 (+)NCBIChiLan1.0ChiLan1.0
NTRK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21677,421,258 - 77,808,559 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11581,101,703 - 81,513,473 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01566,566,219 - 66,953,279 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11585,776,819 - 86,157,209 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1585,776,832 - 86,157,204 (-)Ensemblpanpan1.1panPan2
NTRK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1351,131,470 - 51,491,112 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl351,138,751 - 51,513,024 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha353,770,192 - 54,150,627 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0351,548,386 - 51,933,727 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl351,554,220 - 51,933,726 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1351,071,744 - 51,456,495 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0351,281,270 - 51,665,830 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0351,620,674 - 52,005,592 (-)NCBIUU_Cfam_GSD_1.0
Ntrk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640132,042,602 - 132,426,830 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648313,909,109 - 14,291,887 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648313,912,904 - 14,291,881 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTRK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1296,441,824 - 6,831,029 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl296,447,256 - 6,830,526 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605940,018,915 - 40,410,728 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ntrk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476815,252,354 - 15,619,601 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476815,239,111 - 15,619,979 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NTRK3
8172 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 2 23 3 5 10 10 23 2 6 1

Sequence


Ensembl Acc Id: ENSSSCT00000005628   ⟹   ENSSSCP00000005487
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1191,535,703 - 191,925,324 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000040145   ⟹   ENSSSCP00000058161
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1191,535,688 - 191,925,353 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000044043   ⟹   ENSSSCP00000040262
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1191,535,798 - 191,925,324 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000053046   ⟹   ENSSSCP00000044353
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1191,535,301 - 191,823,216 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000057030   ⟹   ENSSSCP00000056080
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1191,535,882 - 191,925,327 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000067108   ⟹   ENSSSCP00000066833
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1191,535,300 - 191,925,353 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000068344   ⟹   ENSSSCP00000072174
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1191,535,798 - 191,925,324 (+)Ensembl
RefSeq Acc Id: NM_214271   ⟹   NP_999436
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11191,535,266 - 191,925,342 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021083214   ⟹   XP_020938873
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11191,535,262 - 191,941,675 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021083220   ⟹   XP_020938879
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11191,535,739 - 191,941,675 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021083229   ⟹   XP_020938888
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11191,535,739 - 191,823,225 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021083231   ⟹   XP_020938890
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11191,535,739 - 191,823,225 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020938873   ⟸   XM_021083214
- Peptide Label: isoform X1
- UniProtKB: A0A4X1WDT4 (UniProtKB/TrEMBL),   A0A4X1WCV3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_999436   ⟸   NM_214271
- Peptide Label: precursor
- UniProtKB: A0A480DQD2 (UniProtKB/TrEMBL),   A0A4X1WCM2 (UniProtKB/TrEMBL),   A0A8D1U8L7 (UniProtKB/TrEMBL),   F1SRS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020938879   ⟸   XM_021083220
- Peptide Label: isoform X2
- UniProtKB: A0A4X1WCM3 (UniProtKB/TrEMBL),   A0A287A8F5 (UniProtKB/TrEMBL),   A0A8D1WEE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020938888   ⟸   XM_021083229
- Peptide Label: isoform X3
- UniProtKB: A0A480PUD4 (UniProtKB/TrEMBL),   A0A4X1WDT7 (UniProtKB/TrEMBL),   A0A287AK14 (UniProtKB/TrEMBL),   A0A8D1N7H1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020938890   ⟸   XM_021083231
- Peptide Label: isoform X4
- UniProtKB: A0A480N1D5 (UniProtKB/TrEMBL),   A0A4X1WCM8 (UniProtKB/TrEMBL),   A0A8D1N7H1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000005487   ⟸   ENSSSCT00000005628
Ensembl Acc Id: ENSSSCP00000058161   ⟸   ENSSSCT00000040145
Ensembl Acc Id: ENSSSCP00000040262   ⟸   ENSSSCT00000044043
Ensembl Acc Id: ENSSSCP00000072174   ⟸   ENSSSCT00000068344
Ensembl Acc Id: ENSSSCP00000044353   ⟸   ENSSSCT00000053046
Ensembl Acc Id: ENSSSCP00000056080   ⟸   ENSSSCT00000057030
Ensembl Acc Id: ENSSSCP00000066833   ⟸   ENSSSCT00000067108
Protein Domains
Ig-like   Ig-like C2-type   LRRCT   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000005106 Ensembl, ENTREZGENE
Ensembl Transcript ENSSSCT00000005628 ENTREZGENE
  ENSSSCT00000053046 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  3.80.10.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Immunoglobulin UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
  NTRK_C2 UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RTK UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kin_neurotrophic_rcpt_3 UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_NGF_rcpt UniProtKB/Swiss-Prot
  Tyr_kinase_rcpt_2_CS UniProtKB/Swiss-Prot
KEGG Report ssc:397511 UniProtKB/Swiss-Prot
NCBI Gene NTRK3 ENTREZGENE
PANTHER NT-3 GROWTH FACTOR RECEPTOR UniProtKB/Swiss-Prot
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot
Pfam LRR_8 UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
  PF00047 UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
  TPKR_C2 UniProtKB/Swiss-Prot
PRINTS NTKRECEPTOR UniProtKB/Swiss-Prot
  NTKRECEPTOR3 UniProtKB/Swiss-Prot
  TYRKINASE UniProtKB/Swiss-Prot
PROSITE IG_LIKE UniProtKB/Swiss-Prot
  LRR UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  RECEPTOR_TYR_KIN_II UniProtKB/Swiss-Prot
SMART LRRCT UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
  SSF48726 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A287A8F5 ENTREZGENE, UniProtKB/TrEMBL
  A0A287AK14 ENTREZGENE, UniProtKB/TrEMBL
  A0A287BIA0_PIG UniProtKB/TrEMBL
  A0A480DQD2 ENTREZGENE, UniProtKB/TrEMBL
  A0A480N1D5 ENTREZGENE, UniProtKB/TrEMBL
  A0A480PUD4 ENTREZGENE
  A0A4X1W782_PIG UniProtKB/TrEMBL
  A0A4X1WCM2 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1WCM3 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1WCM7_PIG UniProtKB/TrEMBL
  A0A4X1WCM8 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1WCV3 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1WDT4 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1WDT7 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2RJR4_PIG UniProtKB/TrEMBL
  A0A8D0MKY6_PIG UniProtKB/TrEMBL
  A0A8D0TVE7_PIG UniProtKB/TrEMBL
  A0A8D0V6E9_PIG UniProtKB/TrEMBL
  A0A8D0V6Y7_PIG UniProtKB/TrEMBL
  A0A8D0YBZ6_PIG UniProtKB/TrEMBL
  A0A8D1GG21_PIG UniProtKB/TrEMBL
  A0A8D1GLX8_PIG UniProtKB/TrEMBL
  A0A8D1N7H1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1U8L7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1WEE4 ENTREZGENE, UniProtKB/TrEMBL
  F1SRS9 ENTREZGENE, UniProtKB/TrEMBL
  NTRK3_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:103142 ENTREZGENE