OCLN (occludin) - Rat Genome Database

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Gene: OCLN (occludin) Sus scrofa
Analyze
Symbol: OCLN
Name: occludin
RGD ID: 14021365
Description: ENCODES a protein that exhibits protein domain specific binding (inferred); INVOLVED IN cell-cell junction organization (ortholog); cellular response to tumor necrosis factor (ortholog); negative regulation of protein phosphorylation (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); allergic rhinitis (ortholog); amenorrhea (ortholog); FOUND IN apical plasma membrane (ortholog); cell leading edge (ortholog); cell surface (ortholog); INTERACTS WITH (S)-nicotine; 3-acetyldeoxynivalenol; 4-phenylbutyric acid
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1647,600,212 - 47,654,033 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11647,600,175 - 47,652,435 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,547,473 - 51,598,116 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:9247194   PMID:14681463   PMID:19267955   PMID:20197061   PMID:21338560   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
OCLN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1647,600,212 - 47,654,033 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11647,600,175 - 47,652,435 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,547,473 - 51,598,116 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OCLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38569,492,547 - 69,558,104 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl569,492,292 - 69,558,104 (+)EnsemblGRCh38hg38GRCh38
GRCh37568,788,374 - 68,853,931 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36568,823,875 - 68,885,889 (+)NCBINCBI36Build 36hg18NCBI36
Build 34568,823,874 - 68,885,887NCBI
Cytogenetic Map5q13.2NCBI
HuRef565,800,577 - 65,803,347 (+)NCBIHuRef
HuRef565,744,381 - 65,800,380 (+)NCBIHuRef
CHM1_1568,787,783 - 68,853,763 (+)NCBICHM1_1
T2T-CHM13v2.0570,316,240 - 70,383,882 (+)NCBIT2T-CHM13v2.0
Ocln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913100,633,012 - 100,689,226 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13100,633,015 - 100,689,226 (-)EnsemblGRCm39 Ensembl
GRCm3813100,496,504 - 100,552,718 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13100,496,507 - 100,552,718 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713101,267,322 - 101,322,453 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613101,597,624 - 101,652,755 (-)NCBIMGSCv36mm8
Celera13104,112,684 - 104,167,697 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.23NCBI
Ocln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8233,391,303 - 33,442,207 (-)NCBIGRCr8
mRatBN7.2231,657,217 - 31,707,466 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,657,220 - 31,764,150 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx238,791,782 - 38,841,944 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0236,819,361 - 36,869,279 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0231,690,347 - 31,739,905 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0230,527,327 - 30,577,218 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,527,715 - 30,577,218 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0249,686,707 - 49,737,380 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4231,317,090 - 31,367,485 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1231,237,461 - 31,287,854 (-)NCBI
Celera227,670,881 - 27,719,967 (-)NCBICelera
Cytogenetic Map2q12NCBI
Ocln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955575163,646 - 210,379 (+)NCBIChiLan1.0ChiLan1.0
OCLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2444,366,263 - 44,428,662 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1542,519,888 - 42,582,278 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0544,447,230 - 44,509,637 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1546,022,538 - 46,080,549 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl546,023,437 - 46,069,342 (-)Ensemblpanpan1.1panPan2
OCLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,500,299 - 54,545,430 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl254,500,299 - 54,545,430 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha251,466,637 - 51,511,781 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0255,004,936 - 55,058,838 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl255,005,004 - 55,058,769 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1252,076,201 - 52,121,488 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0252,843,313 - 52,888,432 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0253,733,721 - 53,779,092 (+)NCBIUU_Cfam_GSD_1.0
Ocln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213191,162,311 - 191,216,242 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648098,371 - 152,413 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648099,516 - 152,834 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OCLN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1465,581,943 - 65,641,516 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl465,582,460 - 65,644,787 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604914,326,566 - 14,386,556 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ocln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624905333,864 - 388,880 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624905333,853 - 388,990 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in OCLN
1384 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 5 14 12 23 3 6 1

Sequence


Ensembl Acc Id: ENSSSCT00000057617   ⟹   ENSSSCP00000044638
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1647,612,815 - 47,654,033 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000060865   ⟹   ENSSSCP00000041435
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1647,600,498 - 47,654,033 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000094252   ⟹   ENSSSCP00000079905
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1647,600,212 - 47,654,033 (+)Ensembl
RefSeq Acc Id: NM_001163647   ⟹   NP_001157119
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11647,600,522 - 47,650,674 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005672521   ⟹   XP_005672578
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11647,600,491 - 47,652,435 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005672522   ⟹   XP_005672579
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11647,600,175 - 47,652,435 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005672523   ⟹   XP_005672580
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11647,600,599 - 47,652,435 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005672524   ⟹   XP_005672581
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11647,600,504 - 47,652,435 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005672525   ⟹   XP_005672582
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11647,601,367 - 47,652,435 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005672579   ⟸   XM_005672522
- Peptide Label: isoform X1
- UniProtKB: F1SK31 (UniProtKB/TrEMBL),   A0A8D0NRZ7 (UniProtKB/TrEMBL),   I3LGZ9 (UniProtKB/TrEMBL),   A0A4X1UHZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005672578   ⟸   XM_005672521
- Peptide Label: isoform X1
- UniProtKB: F1SK31 (UniProtKB/TrEMBL),   A0A8D0NRZ7 (UniProtKB/TrEMBL),   I3LGZ9 (UniProtKB/TrEMBL),   A0A4X1UHZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005672581   ⟸   XM_005672524
- Peptide Label: isoform X1
- UniProtKB: F1SK31 (UniProtKB/TrEMBL),   A0A8D0NRZ7 (UniProtKB/TrEMBL),   I3LGZ9 (UniProtKB/TrEMBL),   A0A4X1UHZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157119   ⟸   NM_001163647
- UniProtKB: C5JA71 (UniProtKB/TrEMBL),   A0A4X1UHZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005672580   ⟸   XM_005672523
- Peptide Label: isoform X1
- UniProtKB: F1SK31 (UniProtKB/TrEMBL),   A0A8D0NRZ7 (UniProtKB/TrEMBL),   I3LGZ9 (UniProtKB/TrEMBL),   A0A4X1UHZ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005672582   ⟸   XM_005672525
- Peptide Label: isoform X1
- UniProtKB: F1SK31 (UniProtKB/TrEMBL),   A0A8D0NRZ7 (UniProtKB/TrEMBL),   I3LGZ9 (UniProtKB/TrEMBL),   A0A4X1UHZ7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000041435   ⟸   ENSSSCT00000060865
Ensembl Acc Id: ENSSSCP00000044638   ⟸   ENSSSCT00000057617
Ensembl Acc Id: ENSSSCP00000079905   ⟸   ENSSSCT00000094252
Protein Domains
MARVEL   OCEL


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000021514 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015043094 UniProtKB/TrEMBL
  ENSSSCG00025036187 UniProtKB/TrEMBL
  ENSSSCG00030045709 UniProtKB/TrEMBL
  ENSSSCG00035039694 UniProtKB/TrEMBL
  ENSSSCG00040044002 UniProtKB/TrEMBL
  ENSSSCG00045030834 UniProtKB/TrEMBL
  ENSSSCG00050057772 UniProtKB/TrEMBL
  ENSSSCG00055021997 UniProtKB/TrEMBL
  ENSSSCG00060067345 UniProtKB/TrEMBL
  ENSSSCG00065075738 UniProtKB/TrEMBL
  ENSSSCG00070017114 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000057617.2 UniProtKB/TrEMBL
  ENSSSCT00000060865 ENTREZGENE
  ENSSSCT00000060865.2 UniProtKB/TrEMBL
  ENSSSCT00000094252 ENTREZGENE
  ENSSSCT00000094252.1 UniProtKB/TrEMBL
  ENSSSCT00015057759.1 UniProtKB/TrEMBL
  ENSSSCT00025049303.1 UniProtKB/TrEMBL
  ENSSSCT00030063856.1 UniProtKB/TrEMBL
  ENSSSCT00035052719.1 UniProtKB/TrEMBL
  ENSSSCT00035052723.1 UniProtKB/TrEMBL
  ENSSSCT00040059685.1 UniProtKB/TrEMBL
  ENSSSCT00045052716.1 UniProtKB/TrEMBL
  ENSSSCT00050078818.1 UniProtKB/TrEMBL
  ENSSSCT00055043329.1 UniProtKB/TrEMBL
  ENSSSCT00060091928.1 UniProtKB/TrEMBL
  ENSSSCT00065104571.1 UniProtKB/TrEMBL
  ENSSSCT00070033757.1 UniProtKB/TrEMBL
  ENSSSCT00070033768.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.340 UniProtKB/TrEMBL
InterPro ELL/occludin UniProtKB/TrEMBL
  Marvel UniProtKB/TrEMBL
  Occludin UniProtKB/TrEMBL
  Occludin_ELL UniProtKB/TrEMBL
NCBI Gene OCLN ENTREZGENE
PANTHER PTHR23288 UniProtKB/TrEMBL
  PTHR23288:SF4 UniProtKB/TrEMBL
Pfam MARVEL UniProtKB/TrEMBL
  Occludin_ELL UniProtKB/TrEMBL
PIRSF Occludin UniProtKB/TrEMBL
PRINTS OCCLUDIN UniProtKB/TrEMBL
PROSITE MARVEL UniProtKB/TrEMBL
  OCEL UniProtKB/TrEMBL
Superfamily-SCOP occludin/ELL-like UniProtKB/TrEMBL
UniProt A0A287AL69_PIG UniProtKB/TrEMBL
  A0A4X1UHY5_PIG UniProtKB/TrEMBL
  A0A4X1UHZ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0NRZ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FNN0_PIG UniProtKB/TrEMBL
  C5JA71 ENTREZGENE
  F1SK31 ENTREZGENE, UniProtKB/TrEMBL
  I3LGZ9 ENTREZGENE
UniProt Secondary I3LGZ9 UniProtKB/TrEMBL
VGNC ID VGNC:91013 ENTREZGENE