COX17 (cytochrome c oxidase copper chaperone COX17) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: COX17 (cytochrome c oxidase copper chaperone COX17) Sus scrofa
Analyze
Symbol: COX17
Name: cytochrome c oxidase copper chaperone COX17
RGD ID: 14005153
Description: ENCODES a protein that exhibits copper chaperone activity; INVOLVED IN heart development (ortholog); positive regulation of cytochrome-c oxidase activity (ortholog); ASSOCIATED WITH Chronic Hepatitis (ortholog); Lung Neoplasms (ortholog); FOUND IN mitochondrion (ortholog); INTERACTS WITH copper(II) sulfate
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: COX17 cytochrome c oxidase assembly homolog; cytochrome c oxidase copper chaperone; Dopuin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13140,584,363 - 140,587,621 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113140,584,286 - 140,594,636 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213149,914,913 - 149,944,656 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:9370362   PMID:17182746   PMID:17407547   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
COX17
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13140,584,363 - 140,587,621 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113140,584,286 - 140,594,636 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213149,914,913 - 149,944,656 (+)NCBISscrofa10.2Sscrofa10.2susScr3
COX17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383119,663,975 - 119,677,406 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3119,654,513 - 119,677,454 (-)EnsemblGRCh38hg38GRCh38
GRCh373119,382,822 - 119,396,253 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363120,871,062 - 120,878,933 (-)NCBINCBI36Build 36hg18NCBI36
Build 343120,871,061 - 120,878,933NCBI
Celera3117,796,888 - 117,804,750 (-)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3116,764,172 - 116,772,021 (-)NCBIHuRef
CHM1_13119,351,879 - 119,359,738 (-)NCBICHM1_1
T2T-CHM13v2.03122,383,687 - 122,397,091 (-)NCBIT2T-CHM13v2.0
Cox17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391638,167,332 - 38,173,125 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1638,167,353 - 38,182,659 (+)EnsemblGRCm39 Ensembl
GRCm381638,346,983 - 38,352,763 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1638,346,991 - 38,352,763 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl1638,347,040 - 38,362,297 (+)EnsemblGRCm38mm10GRCm38
MGSCv371638,347,085 - 38,352,849 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361638,266,238 - 38,272,002 (+)NCBIMGSCv36mm8
Celera1638,757,318 - 38,763,078 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1626.77NCBI
Cox17
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81175,906,245 - 75,912,036 (-)NCBIGRCr8
mRatBN7.21162,400,733 - 62,406,507 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1171,213,255 - 71,219,029 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01163,875,474 - 63,881,248 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01162,925,841 - 62,931,615 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01164,962,663 - 64,968,437 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,962,666 - 64,968,437 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01167,113,608 - 67,119,382 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,183,573 - 64,185,985 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11164,241,161 - 64,243,574 (-)NCBI
Celera1161,901,400 - 61,907,174 (-)NCBICelera
Cytogenetic Map11q21NCBI
LOC102021151
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542719,376,482 - 19,384,270 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542719,376,482 - 19,384,270 (-)NCBIChiLan1.0ChiLan1.0
LOC100970363
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22117,635,812 - 117,651,655 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13117,640,582 - 117,656,437 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03116,786,430 - 116,796,888 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13123,696,145 - 123,709,178 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3123,701,288 - 123,709,205 (-)Ensemblpanpan1.1panPan2
COX17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13323,305,119 - 23,313,022 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3323,305,085 - 23,313,064 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3323,335,000 - 23,342,902 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03323,542,750 - 23,550,698 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3323,542,719 - 23,550,757 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13323,345,044 - 23,352,977 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03323,380,906 - 23,388,783 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03323,950,638 - 23,958,576 (-)NCBIUU_Cfam_GSD_1.0
LOC101975509
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602130,925,823 - 130,947,006 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365366,560,329 - 6,596,259 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365366,575,010 - 6,596,172 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COX17
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12261,143,400 - 61,151,348 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2261,143,462 - 61,151,299 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041105,160,833 - 105,168,998 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101702679
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473128,481,594 - 28,488,528 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473128,481,591 - 28,488,395 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in COX17
266 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000049241   ⟹   ENSSSCP00000047675
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13140,584,363 - 140,587,621 (+)Ensembl
RefSeq Acc Id: NM_001348525   ⟹   NP_001335454
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113140,584,286 - 140,594,636 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068256   ⟹   XP_020923915
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113140,584,308 - 140,587,623 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001335454   ⟸   NM_001348525
- UniProtKB: P81045 (UniProtKB/Swiss-Prot),   D2XUP7 (UniProtKB/TrEMBL),   A0A4X1T3X0 (UniProtKB/TrEMBL),   A0A8D1IAS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020923915   ⟸   XM_021068256
- Peptide Label: isoform X1
- UniProtKB: P81045 (UniProtKB/Swiss-Prot),   A0A4X1T3X0 (UniProtKB/TrEMBL),   D2XUP7 (UniProtKB/TrEMBL),   A0A8D1IAS9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000047675   ⟸   ENSSSCT00000049241
Protein Domains
CHCH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000011893 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015041044 UniProtKB/TrEMBL
  ENSSSCG00025070640 UniProtKB/TrEMBL
  ENSSSCG00030044731 UniProtKB/TrEMBL
  ENSSSCG00035002501 UniProtKB/TrEMBL
  ENSSSCG00040070772 UniProtKB/TrEMBL
  ENSSSCG00045024441 UniProtKB/TrEMBL
  ENSSSCG00050073590 UniProtKB/TrEMBL
  ENSSSCG00055001566 UniProtKB/TrEMBL
  ENSSSCG00060074591 UniProtKB/TrEMBL
  ENSSSCG00065029582 UniProtKB/TrEMBL
  ENSSSCG00070006191 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000049241 ENTREZGENE
  ENSSSCT00000049241.3 UniProtKB/TrEMBL
  ENSSSCT00015055111.1 UniProtKB/TrEMBL
  ENSSSCT00025097090.1 UniProtKB/TrEMBL
  ENSSSCT00030062441.1 UniProtKB/TrEMBL
  ENSSSCT00035003130.1 UniProtKB/TrEMBL
  ENSSSCT00040097240.1 UniProtKB/TrEMBL
  ENSSSCT00045041697.1 UniProtKB/TrEMBL
  ENSSSCT00050100651.1 UniProtKB/TrEMBL
  ENSSSCT00055002881.1 UniProtKB/TrEMBL
  ENSSSCT00055002887.1 UniProtKB/TrEMBL
  ENSSSCT00060102212.1 UniProtKB/TrEMBL
  ENSSSCT00065039922.1 UniProtKB/TrEMBL
  ENSSSCT00070011789.1 UniProtKB/TrEMBL
  ENSSSCT00070011797.1 UniProtKB/TrEMBL
  ENSSSCT00070011806.1 UniProtKB/TrEMBL
Gene3D-CATH CytochromE C oxidase copper chaperone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cys_alpha_HP_mot_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_c_oxidase_Cu-chaperone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100156799 UniProtKB/TrEMBL
NCBI Gene COX17 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE COPPER CHAPERONE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR16719 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam COX17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CHCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47072 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1T3X0 ENTREZGENE
  A0A8D1IAS9 ENTREZGENE, UniProtKB/TrEMBL
  COX17_PIG UniProtKB/Swiss-Prot
  D2XUP7 ENTREZGENE, UniProtKB/TrEMBL
  P81045 ENTREZGENE
UniProt Secondary A0A4X1T3X0 UniProtKB/TrEMBL
VGNC ID VGNC:86921 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-03-04 COX17  cytochrome c oxidase copper chaperone COX17  COX17  COX17 cytochrome c oxidase assembly homolog  Symbol and/or name change 5135510 APPROVED