DND1 (DND microRNA-mediated repression inhibitor 1) - Rat Genome Database

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Gene: DND1 (DND microRNA-mediated repression inhibitor 1) Sus scrofa
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Symbol: DND1
Name: DND microRNA-mediated repression inhibitor 1
RGD ID: 13972047
Description: ENCODES a protein that exhibits mRNA binding; miRNA binding (ortholog); mRNA 3'-UTR binding (ortholog); INVOLVED IN germ cell development (ortholog); negative regulation of miRNA-mediated gene silencing (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH autosomal dominant intellectual developmental disorder 31 (ortholog); familial adenomatous polyposis 1 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm; nucleus
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dead end homolog 1; dead end protein homolog 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2142,384,532 - 142,387,199 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12142,384,526 - 142,387,407 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22148,328,709 - 148,331,639 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IDA,IEA)
nucleoplasm  (IEA)
nucleus  (IBA,IDA,IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DND1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2142,384,532 - 142,387,199 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12142,384,526 - 142,387,407 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22148,328,709 - 148,331,639 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DND1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385140,670,794 - 140,673,576 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5140,670,794 - 140,673,576 (-)EnsemblGRCh38hg38GRCh38
GRCh375140,050,379 - 140,053,161 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365140,030,565 - 140,033,355 (-)NCBINCBI36Build 36hg18NCBI36
Build 345140,030,565 - 140,033,355NCBI
Celera5136,127,128 - 136,129,918 (-)NCBICelera
Cytogenetic Map5q31.3NCBI
HuRef5135,195,622 - 135,198,412 (-)NCBIHuRef
CHM1_15139,483,630 - 139,486,420 (-)NCBICHM1_1
T2T-CHM13v2.05141,196,191 - 141,198,973 (-)NCBIT2T-CHM13v2.0
Dnd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391836,896,724 - 36,899,267 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1836,896,724 - 36,899,267 (-)EnsemblGRCm39 Ensembl
GRCm381836,763,671 - 36,766,214 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1836,763,671 - 36,766,214 (-)EnsemblGRCm38mm10GRCm38
MGSCv371836,923,325 - 36,925,868 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361836,889,645 - 36,892,188 (-)NCBIMGSCv36mm8
Celera1837,215,735 - 37,218,278 (-)NCBICelera
Cytogenetic Map18B2NCBI
cM Map1819.46NCBI
Dnd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81828,652,712 - 28,655,336 (-)NCBIGRCr8
mRatBN7.21828,378,692 - 28,381,316 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1828,378,692 - 28,381,316 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1828,505,841 - 28,508,465 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01829,267,915 - 29,270,539 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01828,603,143 - 28,605,767 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01829,608,588 - 29,611,212 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1829,608,588 - 29,611,212 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01829,312,395 - 29,315,019 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41829,464,691 - 29,467,315 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1828,099,244 - 28,101,868 (-)NCBICelera
Cytogenetic Map18p11NCBI
Dnd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541830,893 - 32,936 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541830,795 - 33,394 (+)NCBIChiLan1.0ChiLan1.0
DND1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24135,928,635 - 135,931,488 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15134,068,186 - 134,071,155 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05136,035,464 - 136,038,524 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15142,151,441 - 142,154,262 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5142,151,441 - 142,154,262 (-)Ensemblpanpan1.1panPan2
DND1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1235,825,154 - 35,827,913 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl235,825,636 - 35,827,840 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha232,864,141 - 32,867,086 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0236,280,764 - 36,283,709 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl236,281,246 - 36,283,450 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1233,333,099 - 33,336,044 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0234,200,879 - 34,203,823 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0234,953,593 - 34,956,538 (-)NCBIUU_Cfam_GSD_1.0
Dnd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213152,001,258 - 152,003,846 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365319,607,906 - 9,609,965 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365319,607,678 - 9,610,245 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DND1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12343,304,482 - 43,307,479 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2343,304,976 - 43,307,209 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603434,577,251 - 34,580,051 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474333,421,810 - 33,424,635 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474333,421,810 - 33,424,515 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DND1
65 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 1 1 1 3 1 14 1
Below cutoff 7 3 2 2 8 2 2

Sequence


RefSeq Acc Id: ENSSSCT00000015704   ⟹   ENSSSCP00000015291
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2142,384,532 - 142,387,199 (-)Ensembl
RefSeq Acc Id: XM_003124043   ⟹   XP_003124091
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12142,384,526 - 142,387,407 (-)NCBI
Sequence:
RefSeq Acc Id: XP_003124091   ⟸   XM_003124043
- UniProtKB: F1RGE0 (UniProtKB/TrEMBL),   A0A4X1SG21 (UniProtKB/TrEMBL),   A0A8D0MG90 (UniProtKB/TrEMBL),   A0A8D2BJY5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000015291   ⟸   ENSSSCT00000015704
Protein Domains
RRM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000014374 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015005845 UniProtKB/TrEMBL
  ENSSSCG00025053549 UniProtKB/TrEMBL
  ENSSSCG00035078510 UniProtKB/TrEMBL
  ENSSSCG00045015871 UniProtKB/TrEMBL
  ENSSSCG00055002901 UniProtKB/TrEMBL
  ENSSSCG00060041671 UniProtKB/TrEMBL
  ENSSSCG00065077691 UniProtKB/TrEMBL
  ENSSSCG00070000733 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000015704 ENTREZGENE
  ENSSSCT00000015704.3 UniProtKB/TrEMBL
  ENSSSCT00015007804.1 UniProtKB/TrEMBL
  ENSSSCT00025073241.1 UniProtKB/TrEMBL
  ENSSSCT00035107126.1 UniProtKB/TrEMBL
  ENSSSCT00045026968.1 UniProtKB/TrEMBL
  ENSSSCT00055005558.1 UniProtKB/TrEMBL
  ENSSSCT00060056504.1 UniProtKB/TrEMBL
  ENSSSCT00065107506.1 UniProtKB/TrEMBL
  ENSSSCT00070001380.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
InterPro DND1_DSRM UniProtKB/TrEMBL
  DND1_RRM1 UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
KEGG Report ssc:100520423 UniProtKB/TrEMBL
NCBI Gene DND1 ENTREZGENE
PANTHER DEAD END PROTEIN HOMOLOG 1 UniProtKB/TrEMBL
  HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN UniProtKB/TrEMBL
Pfam DND1_DSRM UniProtKB/TrEMBL
  RRM_1 UniProtKB/TrEMBL
PROSITE RRM UniProtKB/TrEMBL
SMART RRM UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A4X1SG21 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0MG90 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D2BJY5 ENTREZGENE, UniProtKB/TrEMBL
  F1RGE0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:87378 ENTREZGENE