AKR1D1 (aldo-keto reductase family 1 member D1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: AKR1D1 (aldo-keto reductase family 1 member D1) Sus scrofa
Analyze
Symbol: AKR1D1
Name: aldo-keto reductase family 1 member D1
RGD ID: 13971239
Description: ENCODES a protein that exhibits 3-oxo-5-beta-steroid 4-dehydrogenase activity (ortholog); INVOLVED IN bile acid biosynthetic process (ortholog); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; ASSOCIATED WITH congenital bile acid synthesis defect (ortholog); congenital bile acid synthesis defect 2 (ortholog); genetic disease (ortholog); FOUND IN cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 3-oxo-5-beta-steroid 4-dehydrogenase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1811,416,068 - 11,531,726 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11811,416,065 - 11,532,846 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21812,091,380 - 12,134,240 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IEA)

References
Additional References at PubMed
PMID:14681463   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AKR1D1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1811,416,068 - 11,531,726 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11811,416,065 - 11,532,846 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21812,091,380 - 12,134,240 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AKR1D1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387138,076,459 - 138,118,305 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7138,002,324 - 138,118,305 (+)EnsemblGRCh38hg38GRCh38
GRCh377137,761,205 - 137,803,051 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367137,411,736 - 137,453,590 (+)NCBINCBI36Build 36hg18NCBI36
Build 347137,218,450 - 137,260,305NCBI
Celera7132,499,985 - 132,541,839 (+)NCBICelera
Cytogenetic Map7q33NCBI
HuRef7132,069,181 - 132,111,033 (+)NCBIHuRef
CHM1_17137,694,698 - 137,736,587 (+)NCBICHM1_1
T2T-CHM13v2.07139,311,690 - 139,427,796 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27137,106,397 - 137,148,256 (+)NCBI
Akr1d1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39637,506,913 - 37,551,856 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl637,507,108 - 37,545,750 (+)EnsemblGRCm39 Ensembl
GRCm38637,529,978 - 37,574,921 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl637,530,173 - 37,568,815 (+)EnsemblGRCm38mm10GRCm38
MGSCv37637,480,173 - 37,518,815 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36637,459,781 - 37,498,003 (+)NCBIMGSCv36mm8
Celera637,517,252 - 37,556,030 (+)NCBICelera
Cytogenetic Map6B1NCBI
cM Map616.44NCBI
Akr1d1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8467,121,288 - 67,154,543 (+)NCBIGRCr8
mRatBN7.2466,154,246 - 66,187,505 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl466,154,248 - 66,186,372 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx471,096,251 - 71,129,493 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0467,017,336 - 67,050,578 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0465,407,781 - 65,440,769 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0465,110,706 - 65,143,930 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl465,110,746 - 65,143,941 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0464,933,143 - 64,965,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4464,972,908 - 65,005,896 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1465,249,037 - 65,282,026 (+)NCBI
Celera461,186,796 - 61,219,854 (+)NCBICelera
Cytogenetic Map4q23NCBI
Akr1d1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554944,799,450 - 4,854,696 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554944,799,706 - 4,856,100 (-)NCBIChiLan1.0ChiLan1.0
AKR1D1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26174,889,295 - 174,931,548 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1726,899,547 - 26,941,800 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07130,023,017 - 130,076,397 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17142,514,914 - 142,568,052 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7142,525,467 - 142,571,331 (+)Ensemblpanpan1.1panPan2
AKR1D1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1161,499,251 - 1,583,965 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1611,172,153 - 11,677,722 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01610,254,191 - 10,279,758 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11610,201,202 - 10,250,574 (-)NCBIUMICH_Zoey_3.1
Akr1d1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511816,696,579 - 16,727,564 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365922,491,681 - 2,522,796 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365922,486,219 - 2,522,796 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKR1D1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121106,705,197 - 106,822,194 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21106,780,339 - 106,822,696 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660723,643,056 - 3,684,108 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akr1d1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476518,406,758 - 18,475,918 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476518,406,859 - 18,474,905 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in AKR1D1
3950 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 2 21 3 2 4 7 7 21 1 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000017987   ⟹   ENSSSCP00000017503
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1811,416,068 - 11,531,726 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000079844   ⟹   ENSSSCP00000072578
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1811,416,068 - 11,531,726 (-)Ensembl
RefSeq Acc Id: XM_021078690   ⟹   XP_020934349
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11811,416,065 - 11,532,821 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021078691   ⟹   XP_020934350
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11811,416,065 - 11,532,846 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021078692   ⟹   XP_020934351
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11811,416,065 - 11,462,111 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020934350   ⟸   XM_021078691
- Peptide Label: isoform X2
- UniProtKB: A0A8D1IJ53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020934349   ⟸   XM_021078690
- Peptide Label: isoform X1
- UniProtKB: A0A4X1VG53 (UniProtKB/TrEMBL),   F1SNJ5 (UniProtKB/TrEMBL),   A0A8D1FCR9 (UniProtKB/TrEMBL),   A0A8D1UHX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020934351   ⟸   XM_021078692
- Peptide Label: isoform X3
- UniProtKB: A0A8D1FCR9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000072578   ⟸   ENSSSCT00000079844
Ensembl Acc Id: ENSSSCP00000017503   ⟸   ENSSSCT00000017987
Protein Domains
NADP-dependent oxidoreductase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000016519 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015074748 UniProtKB/TrEMBL
  ENSSSCG00025055874 UniProtKB/TrEMBL
  ENSSSCG00035028200 UniProtKB/TrEMBL
  ENSSSCG00040061122 UniProtKB/TrEMBL
  ENSSSCG00045028933 UniProtKB/TrEMBL
  ENSSSCG00050038222 UniProtKB/TrEMBL
  ENSSSCG00055027496 UniProtKB/TrEMBL
  ENSSSCG00060010479 UniProtKB/TrEMBL
  ENSSSCG00065049407 UniProtKB/TrEMBL
  ENSSSCG00070025054 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000017987 ENTREZGENE
  ENSSSCT00000017987.5 UniProtKB/TrEMBL
  ENSSSCT00000079844.2 UniProtKB/TrEMBL
  ENSSSCT00015100632.1 UniProtKB/TrEMBL
  ENSSSCT00015100688.1 UniProtKB/TrEMBL
  ENSSSCT00025076471.1 UniProtKB/TrEMBL
  ENSSSCT00025076601.1 UniProtKB/TrEMBL
  ENSSSCT00035037300.1 UniProtKB/TrEMBL
  ENSSSCT00035037304.1 UniProtKB/TrEMBL
  ENSSSCT00040083219.1 UniProtKB/TrEMBL
  ENSSSCT00045049374.1 UniProtKB/TrEMBL
  ENSSSCT00050051543.1 UniProtKB/TrEMBL
  ENSSSCT00050051551.1 UniProtKB/TrEMBL
  ENSSSCT00055054405.1 UniProtKB/TrEMBL
  ENSSSCT00055054453.1 UniProtKB/TrEMBL
  ENSSSCT00060013619.1 UniProtKB/TrEMBL
  ENSSSCT00060013620.1 UniProtKB/TrEMBL
  ENSSSCT00065067637.1 UniProtKB/TrEMBL
  ENSSSCT00065067640.1 UniProtKB/TrEMBL
  ENSSSCT00070050129.1 UniProtKB/TrEMBL
  ENSSSCT00070050153.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/TrEMBL
InterPro AKR1D1 UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/TrEMBL
  Aldo/keto_reductase UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/TrEMBL
NCBI Gene AKR1D1 ENTREZGENE
PANTHER ALDO-KETO REDUCTASE FAMILY 1 MEMBER D1 UniProtKB/TrEMBL
  ALDO/KETO REDUCTASE UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/TrEMBL
PIRSF AKR UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_2 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF51430 UniProtKB/TrEMBL
UniProt A0A4X1VG53 ENTREZGENE
  A0A4X1VK97_PIG UniProtKB/TrEMBL
  A0A8D0Q070_PIG UniProtKB/TrEMBL
  A0A8D1FCR9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1IJ53 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1UHX2 ENTREZGENE, UniProtKB/TrEMBL
  F1SNJ5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A4X1VG53 UniProtKB/TrEMBL
  A0A5G2R8D2 UniProtKB/TrEMBL
VGNC ID VGNC:85230 ENTREZGENE