SPEN (spen family transcriptional repressor) - Rat Genome Database
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Gene: SPEN (spen family transcriptional repressor) Sus scrofa
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Symbol: SPEN
Name: spen family transcriptional repressor
RGD ID: 13970706
Description: ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); single-stranded DNA binding (ortholog); INVOLVED IN negative regulation of transcription, DNA-templated (ortholog); positive regulation of transcription, DNA-templated (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH breast ductal carcinoma (ortholog); Prostatic Neoplasms (ortholog); FOUND IN nucleoplasm (inferred); transcription repressor complex (inferred); INTERACTS WITH resveratrol
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: msx2-interacting protein; spen homolog, transcriptional regulator
Orthologs:
Homo sapiens (human) : SPEN (spen family transcriptional repressor)  HGNC  Alliance
Mus musculus (house mouse) : Spen (spen family transcription repressor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Spen (spen family transcriptional repressor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spen (spen family transcriptional repressor)
Pan paniscus (bonobo/pygmy chimpanzee) : SPEN (spen family transcriptional repressor)
Canis lupus familiaris (dog) : SPEN (spen family transcriptional repressor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spen (spen family transcriptional repressor)
Chlorocebus sabaeus (African green monkey) : SPEN (spen family transcriptional repressor)
Heterocephalus glaber (naked mole-rat) : Spen (spen family transcriptional repressor)
more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl675,015,521 - 75,107,033 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1675,015,565 - 75,107,468 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
resveratrol  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
SPEN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl675,015,521 - 75,107,033 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1675,015,565 - 75,107,468 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SPEN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl115,836,095 - 15,940,456 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl115,847,707 - 15,940,456 (+)EnsemblGRCh38hg38GRCh38
GRCh38115,847,707 - 15,940,456 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37116,174,359 - 16,266,951 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,046,946 - 16,139,537 (+)NCBINCBI36hg18NCBI36
Build 34115,919,664 - 16,012,256NCBI
Celera114,654,230 - 14,746,824 (+)NCBI
Cytogenetic Map1p36.21-p36.13NCBI
HuRef114,692,961 - 14,785,958 (+)NCBIHuRef
CHM1_1115,972,883 - 16,065,485 (+)NCBICHM1_1
Spen
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,195,199 - 141,265,955 (-)NCBI
GRCm384141,467,885 - 141,538,644 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,467,890 - 141,538,597 (-)EnsemblGRCm38mm10GRCm38
MGSCv374141,023,805 - 141,094,512 (-)NCBIGRCm37mm9NCBIm37
MGSCv364140,740,934 - 140,794,407 (-)NCBImm8
Celera4143,285,155 - 143,361,424 (-)NCBICelera
Cytogenetic Map4D3NCBI
Spen
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05160,015,573 - 160,070,915 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5160,015,454 - 160,070,965 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05163,735,389 - 163,790,132 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,359,738 - 160,414,311 (-)NCBIRGSC3.4rn4RGSC3.4
Celera5152,134,833 - 152,205,318 (-)NCBICelera
Cytogenetic Map5q36NCBI
Spen
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555272,280,459 - 2,343,262 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555272,279,438 - 2,343,263 (-)NCBIChiLan1.0ChiLan1.0
SPEN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1116,004,908 - 16,072,585 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,004,473 - 16,072,585 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0114,987,415 - 15,079,477 (+)NCBIMhudiblu_PPA_v0panPan3
SPEN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,683,824 - 81,775,904 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Spen
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364743,473,892 - 3,535,307 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPEN
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl20116,361,008 - 116,458,064 (-)Ensembl
ChlSab1.120116,359,981 - 116,458,156 (-)NCBI
Spen
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247642,058,689 - 2,144,640 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 2 3 5 1 12 1 3 3
Low 2 2 1 11 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000042154   ⟹   ENSSSCP00000057938
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl675,015,521 - 75,103,474 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000064339   ⟹   ENSSSCP00000031666
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl675,015,521 - 75,103,474 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000080789   ⟹   ENSSSCP00000073372
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl675,096,707 - 75,107,033 (+)Ensembl
RefSeq Acc Id: XM_021095393   ⟹   XP_020951052
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1675,015,565 - 75,107,468 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020951052 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein JAG69140 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020951052   ⟸   XM_021095393
- Sequence:
RefSeq Acc Id: ENSSSCP00000031666   ⟸   ENSSSCT00000064339
RefSeq Acc Id: ENSSSCP00000073372   ⟸   ENSSSCT00000080789
RefSeq Acc Id: ENSSSCP00000057938   ⟸   ENSSSCT00000042154
Protein Domains
RRM   SPOC


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000034484 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000031666 UniProtKB/TrEMBL
  ENSSSCP00000057938 UniProtKB/TrEMBL
  ENSSSCP00000073372 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000042154 UniProtKB/TrEMBL
  ENSSSCT00000064339 UniProtKB/TrEMBL
  ENSSSCT00000080789 UniProtKB/TrEMBL
Gene3D-CATH 2.40.290.10 UniProtKB/TrEMBL
  3.30.70.330 UniProtKB/TrEMBL
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
  SHARP_RRM3 UniProtKB/TrEMBL
  SHARP_RRM4 UniProtKB/TrEMBL
  SPOC-like_C_dom_sf UniProtKB/TrEMBL
  SPOC_C UniProtKB/TrEMBL
  SPOC_met UniProtKB/TrEMBL
NCBI Gene SPEN ENTREZGENE
Pfam RRM_1 UniProtKB/TrEMBL
  SPOC UniProtKB/TrEMBL
PROSITE RRM UniProtKB/TrEMBL
  SPOC UniProtKB/TrEMBL
SMART RRM UniProtKB/TrEMBL
Superfamily-SCOP SSF100939 UniProtKB/TrEMBL
  SSF54928 UniProtKB/TrEMBL
UniProt A0A286ZJD3_PIG UniProtKB/TrEMBL
  A0A287BPC2_PIG UniProtKB/TrEMBL
  A0A5G2RF57_PIG UniProtKB/TrEMBL
VGNC ID VGNC:93400 ENTREZGENE