CCR5 (C-C motif chemokine receptor 5) - Rat Genome Database

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Gene: CCR5 (C-C motif chemokine receptor 5) Sus scrofa
Analyze
Symbol: CCR5
Name: C-C motif chemokine receptor 5
RGD ID: 13966324
Description: ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN apoptotic process (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); cellular response to tumor necrosis factor (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; ASSOCIATED WITH acquired immunodeficiency syndrome (ortholog); Acute Hepatitis (ortholog); acute kidney failure (ortholog); FOUND IN cell surface (ortholog); endosome (ortholog); INTERACTS WITH bis(2-chloroethyl) sulfide; dibromine; prostaglandin F2alpha
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-C chemokine receptor type 5; chemokine (C-C motif) receptor 5
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,383,303 - 29,387,895 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,382,383 - 29,387,902 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,546,545 - 32,551,732 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (ISO)
Acute Hepatitis  (ISO)
acute kidney failure  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
anterior uveitis  (ISO)
Arterial Injury  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
Birth Injuries  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chlamydia  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Coronavirus infectious disease  (ISO)
cutaneous leishmaniasis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Disease Progression  (ISO)
dry eye syndrome  (ISO)
end stage renal disease  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Experimental Seizures  (ISO)
fallopian tube disease  (ISO)
Fever  (ISO)
Flaviviridae Infections  (ISO)
gallbladder cancer  (ISO)
glaucoma  (ISO)
graft-versus-host disease  (ISO)
granulomatosis with polyangiitis  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
Herpes Simplex Encephalitis  (ISO)
herpes simplex virus keratitis  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
Inflammation  (ISO)
interstitial lung disease  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kawasaki disease  (ISO)
keratoconjunctivitis sicca  (ISO)
leishmaniasis  (ISO)
Liver Injury  (ISO)
Lymphatic Metastasis  (ISO)
metabolic dysfunction and alcohol associated liver disease  (ISO)
multiple sclerosis  (ISO)
Mycoplasma Infections  (ISO)
Mycoplasma pneumoniae pneumonia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
optic neuritis  (ISO)
Oral Lichen Planus  (ISO)
orchitis  (ISO)
ovarian carcinoma  (ISO)
pancreatic cancer  (ISO)
paracoccidioidomycosis  (ISO)
Perennial Allergic Rhinitis  (ISO)
plague  (ISO)
pleural tuberculosis  (ISO)
pneumonia  (ISO)
posterior uveitis  (ISO)
Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy  (ISO)
psoriasis  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Respirovirus Infections  (ISO)
rheumatoid arthritis  (ISO)
sarcoidosis  (ISO)
Sjogren's syndrome  (ISO)
status epilepticus  (ISO)
syphilis  (ISO)
systemic lupus erythematosus  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 1 diabetes mellitus 22  (ISO)
type 2 diabetes mellitus  (ISO)
Ulcer  (ISO)
urticaria  (ISO)
uveitis  (ISO)
visceral leishmaniasis  (ISO)
West Nile fever  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (ISO)
calcium ion transport  (IEA)
calcium-mediated signaling  (IBA,IEA)
cell chemotaxis  (IBA)
cell-cell signaling  (IEA)
cellular response to lipopolysaccharide  (IEA)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
chemokine-mediated signaling pathway  (IEA)
chemotaxis  (IEA)
defense response  (ISO)
defense response to bacterium  (ISO)
fat cell differentiation  (ISO)
forebrain development  (ISO)
G protein-coupled receptor signaling pathway  (IEA)
immune response  (IBA,IEA)
inflammatory response  (IBA,IEA)
inflammatory response to antigenic stimulus  (ISO)
MAPK cascade  (IEA)
negative regulation of axon extension  (ISO)
negative regulation of macrophage apoptotic process  (ISO)
negative regulation of neural precursor cell proliferation  (ISO)
positive regulation of cell killing  (ISO)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of cytosolic calcium ion concentration  (IBA,ISO)
positive regulation of fever generation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
regulation of cell migration  (ISO)
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (IEA)
response to cholesterol  (IEA)
response to ionizing radiation  (ISO)
response to lipopolysaccharide  (ISO)
signaling  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:15777643   PMID:16926016   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CCR5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,383,303 - 29,387,895 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,382,383 - 29,387,902 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,546,545 - 32,551,732 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCR5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,370,142 - 46,376,206 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,370,946 - 46,376,206 (+)EnsemblGRCh38hg38GRCh38
GRCh37346,411,633 - 46,417,697 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,386,637 - 46,392,701 (+)NCBINCBI36Build 36hg18NCBI36
Celera346,348,960 - 46,355,024 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,455,276 - 46,461,340 (+)NCBIHuRef
CHM1_1346,361,630 - 46,367,689 (+)NCBICHM1_1
T2T-CHM13v2.0346,385,976 - 46,392,040 (+)NCBIT2T-CHM13v2.0
Ccr5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,921,557 - 123,934,153 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9123,921,580 - 123,947,736 (+)EnsemblGRCm39 Ensembl
GRCm389124,121,543 - 124,127,183 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9124,121,543 - 124,147,699 (+)EnsemblGRCm38mm10GRCm38
MGSCv379124,036,282 - 124,041,922 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera9124,872,533 - 124,878,180 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map975.05NCBI
Ccr5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,629,097 - 132,660,980 (+)NCBIGRCr8
mRatBN7.28123,752,423 - 123,757,538 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,752,325 - 123,759,260 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8129,343,076 - 129,348,190 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08127,542,196 - 127,547,310 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08125,360,117 - 125,365,231 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08133,192,398 - 133,215,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8133,197,032 - 133,215,614 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08132,362,664 - 132,367,779 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,907,157 - 128,912,272 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18128,929,594 - 128,932,000 (+)NCBI
Celera8122,847,673 - 122,852,786 (+)NCBICelera
Cytogenetic Map8q32NCBI
CCR5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,330,233 - 46,335,608 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,335,001 - 46,340,376 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,273,096 - 46,278,471 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,377,564 - 47,383,625 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,380,321 - 47,381,379 (+)Ensemblpanpan1.1panPan2
CCR5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,293,288 - 42,297,952 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,294,996 - 42,297,952 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,210,909 - 42,213,866 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02042,775,514 - 42,780,183 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,775,514 - 42,780,191 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12042,018,434 - 42,021,393 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,419,865 - 42,422,824 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,700,801 - 42,703,760 (-)NCBIUU_Cfam_GSD_1.0
CCR5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,803,794 - 7,818,112 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041159,335,032 - 159,341,705 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in CCR5
142 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000025459   ⟹   ENSSSCP00000019995
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1329,383,303 - 29,387,895 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000079611   ⟹   ENSSSCP00000072998
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1329,383,370 - 29,387,874 (+)Ensembl
RefSeq Acc Id: NM_001001618   ⟹   NP_001001618
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11329,383,336 - 29,387,900 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013981569   ⟹   XP_013837023
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11329,382,383 - 29,387,902 (+)NCBI
Sequence:
RefSeq Acc Id: XP_013837023   ⟸   XM_013981569
- Peptide Label: isoform X1
- UniProtKB: A0A4X1TA26 (UniProtKB/TrEMBL),   A0A8D0ZJ93 (UniProtKB/TrEMBL),   A0A8D1N8F0 (UniProtKB/TrEMBL),   Q6YT41 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001001618   ⟸   NM_001001618
- UniProtKB: A0A4X1TA26 (UniProtKB/TrEMBL),   A0A8D0ZJ93 (UniProtKB/TrEMBL),   A0A8D1N8F0 (UniProtKB/TrEMBL),   Q6YT41 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000019995   ⟸   ENSSSCT00000025459
Ensembl Acc Id: ENSSSCP00000072998   ⟸   ENSSSCT00000079611

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000024344 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015022312 UniProtKB/TrEMBL
  ENSSSCG00025051997 UniProtKB/TrEMBL
  ENSSSCG00030034520 UniProtKB/TrEMBL
  ENSSSCG00035036016 UniProtKB/TrEMBL
  ENSSSCG00040029255 UniProtKB/TrEMBL
  ENSSSCG00050058514 UniProtKB/TrEMBL
  ENSSSCG00055008336 UniProtKB/TrEMBL
  ENSSSCG00060004232 UniProtKB/TrEMBL
  ENSSSCG00065032644 UniProtKB/TrEMBL
  ENSSSCG00070007506 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000025459 ENTREZGENE
  ENSSSCT00000025459.4 UniProtKB/TrEMBL
  ENSSSCT00000079611.1 UniProtKB/TrEMBL
  ENSSSCT00015029519.1 UniProtKB/TrEMBL
  ENSSSCT00015029557.1 UniProtKB/TrEMBL
  ENSSSCT00015029608.1 UniProtKB/TrEMBL
  ENSSSCT00025071118.1 UniProtKB/TrEMBL
  ENSSSCT00025071181.1 UniProtKB/TrEMBL
  ENSSSCT00025071225.1 UniProtKB/TrEMBL
  ENSSSCT00030047767.1 UniProtKB/TrEMBL
  ENSSSCT00030047786.1 UniProtKB/TrEMBL
  ENSSSCT00030047813.1 UniProtKB/TrEMBL
  ENSSSCT00035047733.1 UniProtKB/TrEMBL
  ENSSSCT00040039330.1 UniProtKB/TrEMBL
  ENSSSCT00040039349.1 UniProtKB/TrEMBL
  ENSSSCT00040039384.1 UniProtKB/TrEMBL
  ENSSSCT00050079758.1 UniProtKB/TrEMBL
  ENSSSCT00050079764.1 UniProtKB/TrEMBL
  ENSSSCT00050079767.1 UniProtKB/TrEMBL
  ENSSSCT00055016258.1 UniProtKB/TrEMBL
  ENSSSCT00055016297.1 UniProtKB/TrEMBL
  ENSSSCT00055016314.1 UniProtKB/TrEMBL
  ENSSSCT00060005240.1 UniProtKB/TrEMBL
  ENSSSCT00060005251.1 UniProtKB/TrEMBL
  ENSSSCT00060005256.1 UniProtKB/TrEMBL
  ENSSSCT00065044278.1 UniProtKB/TrEMBL
  ENSSSCT00065044288.1 UniProtKB/TrEMBL
  ENSSSCT00065044297.1 UniProtKB/TrEMBL
  ENSSSCT00070014464.1 UniProtKB/TrEMBL
  ENSSSCT00070014470.1 UniProtKB/TrEMBL
  ENSSSCT00070014473.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro Chemokine_CCR5 UniProtKB/TrEMBL
  Chemokine_rcpt UniProtKB/TrEMBL
  GPCR1 UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
KEGG Report ssc:414371 UniProtKB/TrEMBL
NCBI Gene CCR5 ENTREZGENE
PANTHER C-C CHEMOKINE RECEPTOR TYPE 5 UniProtKB/TrEMBL
  CELL ADHESION MOLECULE UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS CCCHEMOKINER UniProtKB/TrEMBL
  CHEMOKINER5 UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A4X1T973_PIG UniProtKB/TrEMBL
  A0A4X1TA26 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2RL73_PIG UniProtKB/TrEMBL
  A0A8D0WIK1_PIG UniProtKB/TrEMBL
  A0A8D0WK72_PIG UniProtKB/TrEMBL
  A0A8D0ZJ93 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1N8F0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1SG86_PIG UniProtKB/TrEMBL
  Q6YT41 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:108636 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-02-14 CCR5  C-C motif chemokine receptor 5  CCR5  chemokine (C-C motif) receptor 5  Symbol and/or name change 19259463 PROVISIONAL