AKR1E2 (aldo-keto reductase family 1 member E2) - Rat Genome Database

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Gene: AKR1E2 (aldo-keto reductase family 1 member E2) Sus scrofa
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Symbol: AKR1E2
Name: aldo-keto reductase family 1 member E2
RGD ID: 13951230
Description: ENCODES a protein that exhibits 1,5-anhydro-D-fructose reductase activity (inferred); oxidoreductase activity (inferred); ASSOCIATED WITH hypoparathyroidism-deafness-renal disease syndrome (ortholog); schizophrenia (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1,5-anhydro-D-fructose reductase; AF reductase; AKR1CL2; Aldo-keto reductase family 1 member C-like protein 2; Aldo-keto reductase family 1 member CL2; putative aldo-keto reductase family 1 member CL2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1065,680,332 - 65,702,190 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11065,680,314 - 65,704,701 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21072,108,978 - 72,133,547 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA)

Molecular Function

References
Additional References at PubMed
PMID:9504428   PMID:14681463   PMID:15808308   PMID:16970816   PMID:17145712   PMID:30032202  


Genomics

Comparative Map Data
AKR1E2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1065,680,332 - 65,702,190 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11065,680,314 - 65,704,701 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21072,108,978 - 72,133,547 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AKR1E2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38104,824,973 - 4,873,237 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl104,786,629 - 4,848,062 (+)EnsemblGRCh38hg38GRCh38
GRCh37104,868,369 - 4,890,254 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36104,858,402 - 4,880,254 (+)NCBINCBI36Build 36hg18NCBI36
Build 34104,858,425 - 4,880,249NCBI
Celera104,811,323 - 4,833,177 (+)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef104,802,403 - 4,824,264 (+)NCBIHuRef
CHM1_1104,868,717 - 4,890,574 (+)NCBICHM1_1
T2T-CHM13v2.0104,825,330 - 4,873,573 (+)NCBIT2T-CHM13v2.0
Akr1e1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,641,122 - 4,659,163 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl134,640,749 - 4,659,173 (-)EnsemblGRCm39 Ensembl
GRCm38134,591,123 - 4,609,164 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,590,750 - 4,609,174 (-)EnsemblGRCm38mm10GRCm38
MGSCv37134,591,736 - 4,608,410 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36134,591,777 - 4,608,381 (-)NCBIMGSCv36mm8
Celera134,571,016 - 4,587,416 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map132.57NCBI
Akr1e2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81770,645,835 - 70,660,366 (+)NCBIGRCr8
mRatBN7.21765,735,909 - 65,750,441 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1765,735,943 - 65,750,441 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1769,231,629 - 69,246,118 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,060,477 - 73,074,961 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,103,460 - 67,117,949 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,365,437 - 69,379,944 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,365,453 - 69,379,947 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01771,079,217 - 71,093,701 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,011,336 - 77,025,824 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11777,022,168 - 77,036,651 (+)NCBI
Celera1765,268,655 - 65,283,123 (+)NCBICelera
Cytogenetic Map17q12.2NCBI
Akr1e2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955429715,157 - 731,303 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955429714,843 - 731,285 (-)NCBIChiLan1.0ChiLan1.0
AKR1E2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2817,376,873 - 17,506,881 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11017,379,890 - 17,404,469 (+)NCBINHGRI_mPanPan1
PanPan1.1104,850,001 - 4,872,215 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl104,850,001 - 4,872,210 (+)Ensemblpanpan1.1panPan2
AKR1E2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1230,694,119 - 30,706,693 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl230,694,249 - 30,706,637 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha227,723,671 - 27,736,248 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0231,074,880 - 31,087,459 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl231,074,883 - 31,087,898 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1228,164,234 - 28,176,774 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0229,001,557 - 29,014,106 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0229,725,464 - 29,738,044 (-)NCBIUU_Cfam_GSD_1.0
Akr1e2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934433,305,613 - 33,325,444 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364849,474,458 - 9,490,676 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364849,472,920 - 9,490,624 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKR1E2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.195,012,793 - 5,033,946 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl95,013,032 - 5,033,947 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605110,188,747 - 10,209,140 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in AKR1E2
756 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 1 5 14 12 23 3 6 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001044568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_145511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013980351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013980352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021064075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021064076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002336115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB337983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF180028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB808243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ474064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FP016195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FP085453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01091812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSSCT00000012204   ⟹   ENSSSCP00000011891
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1065,680,332 - 65,704,867 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000041150   ⟹   ENSSSCP00000033922
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1065,680,365 - 65,693,469 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000052191   ⟹   ENSSSCP00000046702
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1065,680,332 - 65,702,190 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000065406   ⟹   ENSSSCP00000038101
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1065,680,365 - 65,691,642 (-)Ensembl
RefSeq Acc Id: NM_001044568   ⟹   NP_001038033
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11065,680,314 - 65,693,449 (-)NCBI
Sequence:
RefSeq Acc Id: NR_145511
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11065,680,314 - 65,693,449 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013980351   ⟹   XP_013835805
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11065,680,318 - 65,704,691 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013980352   ⟹   XP_013835806
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11065,680,318 - 65,704,691 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021064075   ⟹   XP_020919734
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11065,680,318 - 65,704,701 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021064076   ⟹   XP_020919735
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11065,680,318 - 65,704,115 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002336115
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11065,680,318 - 65,704,691 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001038033   ⟸   NM_001044568
- UniProtKB: Q1KLB5 (UniProtKB/Swiss-Prot),   P82125 (UniProtKB/Swiss-Prot),   A0A480M8G9 (UniProtKB/TrEMBL),   A0A481C947 (UniProtKB/TrEMBL),   A0A8D0P836 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020919734   ⟸   XM_021064075
- Peptide Label: isoform X1
- UniProtKB: P82125 (UniProtKB/Swiss-Prot),   Q1KLB5 (UniProtKB/Swiss-Prot),   A0A480M8G9 (UniProtKB/TrEMBL),   A0A481C947 (UniProtKB/TrEMBL),   A0A8D0P836 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013835806   ⟸   XM_013980352
- Peptide Label: isoform X1
- UniProtKB: Q1KLB5 (UniProtKB/Swiss-Prot),   P82125 (UniProtKB/Swiss-Prot),   A0A480M8G9 (UniProtKB/TrEMBL),   A0A481C947 (UniProtKB/TrEMBL),   A0A8D0P836 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013835805   ⟸   XM_013980351
- Peptide Label: isoform X1
- UniProtKB: Q1KLB5 (UniProtKB/Swiss-Prot),   P82125 (UniProtKB/Swiss-Prot),   A0A480M8G9 (UniProtKB/TrEMBL),   A0A481C947 (UniProtKB/TrEMBL),   A0A8D0P836 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020919735   ⟸   XM_021064076
- Peptide Label: isoform X1
- UniProtKB: P82125 (UniProtKB/Swiss-Prot),   Q1KLB5 (UniProtKB/Swiss-Prot),   A0A480M8G9 (UniProtKB/TrEMBL),   A0A481C947 (UniProtKB/TrEMBL),   A0A8D0P836 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000033922   ⟸   ENSSSCT00000041150
Ensembl Acc Id: ENSSSCP00000038101   ⟸   ENSSSCT00000065406
Ensembl Acc Id: ENSSSCP00000011891   ⟸   ENSSSCT00000012204
Ensembl Acc Id: ENSSSCP00000046702   ⟸   ENSSSCT00000052191

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000036941 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00005018482 UniProtKB/Swiss-Prot
  ENSSSCG00015054786 UniProtKB/TrEMBL
  ENSSSCG00025024226 UniProtKB/Swiss-Prot
  ENSSSCG00030061720 UniProtKB/TrEMBL
  ENSSSCG00035022798 UniProtKB/Swiss-Prot
  ENSSSCG00045028552 UniProtKB/Swiss-Prot
  ENSSSCG00050016185 UniProtKB/TrEMBL
  ENSSSCG00055001205 UniProtKB/Swiss-Prot
  ENSSSCG00060063649 UniProtKB/Swiss-Prot
  ENSSSCG00065062289 UniProtKB/Swiss-Prot
  ENSSSCG00070006087 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000041150 ENTREZGENE
  ENSSSCT00000041150.3 UniProtKB/TrEMBL
  ENSSSCT00000052191 ENTREZGENE
  ENSSSCT00000052191.2 UniProtKB/Swiss-Prot
  ENSSSCT00000065406 ENTREZGENE
  ENSSSCT00000065406.3 UniProtKB/TrEMBL
  ENSSSCT00005029791.1 UniProtKB/Swiss-Prot
  ENSSSCT00005029824.1 UniProtKB/Swiss-Prot
  ENSSSCT00005029849.1 UniProtKB/Swiss-Prot
  ENSSSCT00015073130.1 UniProtKB/TrEMBL
  ENSSSCT00025032851.1 UniProtKB/Swiss-Prot
  ENSSSCT00030086308.1 UniProtKB/TrEMBL
  ENSSSCT00035029808.1 UniProtKB/Swiss-Prot
  ENSSSCT00045048830.1 UniProtKB/Swiss-Prot
  ENSSSCT00050022046.1 UniProtKB/TrEMBL
  ENSSSCT00055002173.1 UniProtKB/Swiss-Prot
  ENSSSCT00060086891.1 UniProtKB/Swiss-Prot
  ENSSSCT00065085447.1 UniProtKB/Swiss-Prot
  ENSSSCT00065085458.1 UniProtKB/Swiss-Prot
  ENSSSCT00070011622.1 UniProtKB/Swiss-Prot
  ENSSSCT00070011628.1 UniProtKB/Swiss-Prot
  ENSSSCT00070011653.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AKR1E2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldo/keto_reductase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:733633 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene AKR1E2 ENTREZGENE
PANTHER 1,5-ANHYDRO-D-FRUCTOSE REDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDO/KETO REDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF AKR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A286ZQQ7_PIG UniProtKB/TrEMBL
  A0A480M8G9 ENTREZGENE, UniProtKB/TrEMBL
  A0A481C947 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1T442_PIG UniProtKB/TrEMBL
  A0A5S6HCI3_PIG UniProtKB/TrEMBL
  A0A8D0P836 ENTREZGENE, UniProtKB/TrEMBL
  AKCL2_PIG UniProtKB/Swiss-Prot, ENTREZGENE
  Q1KLB5 ENTREZGENE
UniProt Secondary Q1KLB5 UniProtKB/Swiss-Prot
VGNC ID VGNC:96003 ENTREZGENE