UCP2 (uncoupling protein 2) - Rat Genome Database

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Gene: UCP2 (uncoupling protein 2) Sus scrofa
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Symbol: UCP2
Name: uncoupling protein 2
RGD ID: 13948817
Description: ENCODES a protein that exhibits antiporter activity (ortholog); L-aspartate transmembrane transporter activity (ortholog); malate transmembrane transporter activity (ortholog); INVOLVED IN C4-dicarboxylate transport (ortholog); cellular response to amino acid starvation (ortholog); cellular response to glucose stimulus (ortholog); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH 3-methylglutaconic aciduria type 7b (ortholog); Acute Liver Failure (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN membrane (inferred); mitochondrial inner membrane (inferred); mitochondrial membrane (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dicarboxylate carrier SLC25A8; dicarboxylate carrier UCP2; mitochondrial uncoupling protein 2; SLC25A8; solute carrier family 25 member 8; UCP 2; uncoupling protein homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl98,358,025 - 8,365,547 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.198,358,559 - 8,364,552 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.299,147,996 - 9,155,017 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9p24-p21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive thermogenesis  (IBA)
C4-dicarboxylate transport  (IEA,ISS)
cellular response to amino acid starvation  (ISO)
cellular response to glucose stimulus  (IEA,ISO,ISS)
cellular response to hormone stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to lead ion  (ISO)
chloride transmembrane transport  (IEA)
glutamine metabolic process  (IEA,ISS)
glycolytic process  (IEA,ISS)
inorganic anion transport  (IEA)
L-aspartate transmembrane transport  (IEA)
liver regeneration  (ISO)
long-chain fatty acid transport  (IEA)
macrophage differentiation  (IEA,ISS)
malate transmembrane transport  (IEA)
mitochondrial fission  (IEA,ISS)
mitochondrial transmembrane transport  (IBA,IEA,ISS)
mitochondrial transport  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of calcium import into the mitochondrion  (IEA)
negative regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
negative regulation of neuron apoptotic process  (IEA,ISO)
oxaloacetate(2-) transmembrane transport  (IEA)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of response to biotic stimulus  (ISO)
proton transmembrane transport  (IEA)
reactive oxygen species metabolic process  (IEA,ISS)
regulation of mitochondrial membrane potential  (IEA)
response to cold  (IBA)
response to dexamethasone  (ISO)
response to fatty acid  (ISO)
response to glucose  (ISO)
response to hypoxia  (IEA,ISO)
response to superoxide  (ISO)
sulfate transmembrane transport  (IEA)
transmembrane transport  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:10442987   PMID:14681463   PMID:16335813   PMID:17221299   PMID:17383207   PMID:22301074   PMID:25199570   PMID:30032202  


Genomics

Comparative Map Data
UCP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl98,358,025 - 8,365,547 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.198,358,559 - 8,364,552 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.299,147,996 - 9,155,017 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9p24-p21NCBI
UCP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381173,974,672 - 73,983,202 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1173,974,061 - 73,982,843 (-)EnsemblGRCh38hg38GRCh38
GRCh371173,685,717 - 73,694,247 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361173,363,364 - 73,371,537 (-)NCBINCBI36Build 36hg18NCBI36
Build 341173,363,363 - 73,371,537NCBI
Celera1170,992,461 - 71,000,634 (-)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1169,981,482 - 69,989,655 (-)NCBIHuRef
CHM1_11173,569,569 - 73,577,739 (-)NCBICHM1_1
T2T-CHM13v2.01173,903,817 - 73,912,347 (-)NCBIT2T-CHM13v2.0
Ucp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397100,142,565 - 100,148,832 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7100,142,544 - 100,151,227 (+)EnsemblGRCm39 Ensembl
GRCm387100,493,337 - 100,499,629 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7100,493,337 - 100,502,020 (+)EnsemblGRCm38mm10GRCm38
MGSCv377107,641,854 - 107,650,682 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367100,367,446 - 100,376,102 (+)NCBIMGSCv36mm8
Celera7100,830,936 - 100,839,747 (+)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.36NCBI
Ucp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81164,251,373 - 164,257,742 (+)NCBIGRCr8
mRatBN7.21154,839,242 - 154,845,612 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1154,839,209 - 154,845,611 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1162,834,282 - 162,840,647 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,014,387 - 170,020,752 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01162,888,256 - 162,894,621 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,506,375 - 165,512,744 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,506,361 - 165,512,744 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01171,707,625 - 171,713,991 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,925,514 - 157,928,222 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11158,000,971 - 158,007,311 (+)NCBI
Celera1152,922,529 - 152,928,898 (+)NCBICelera
RH 3.4 Map11261.4RGD
Cytogenetic Map1q32NCBI
Ucp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541417,592,914 - 17,596,477 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541417,592,914 - 17,596,477 (+)NCBIChiLan1.0ChiLan1.0
UCP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2974,916,276 - 74,923,240 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11175,960,189 - 75,967,154 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01169,047,397 - 69,056,056 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11172,354,529 - 72,363,185 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1172,354,529 - 72,363,185 (-)Ensemblpanpan1.1panPan2
UCP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12124,304,410 - 24,311,392 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2124,304,457 - 24,311,128 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2124,075,387 - 24,078,118 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02124,510,583 - 24,517,796 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2124,510,627 - 24,520,713 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12124,310,265 - 24,312,996 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02124,510,181 - 24,512,912 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02124,425,514 - 24,428,245 (+)NCBIUU_Cfam_GSD_1.0
Ucp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494761,460,097 - 61,466,425 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364983,059,297 - 3,066,197 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364983,059,700 - 3,066,112 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UCP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1165,238,311 - 65,246,841 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl165,235,775 - 65,246,450 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604360,637,629 - 60,646,847 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ucp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248173,067,320 - 3,075,043 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248173,067,358 - 3,075,045 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in UCP2
291 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000016185   ⟹   ENSSSCP00000015752
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl98,358,025 - 8,365,547 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000084408   ⟹   ENSSSCP00000064413
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl98,358,914 - 8,365,558 (-)Ensembl
RefSeq Acc Id: NM_214289   ⟹   NP_999454
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.198,358,559 - 8,364,552 (-)NCBI
Sequence:
RefSeq Acc Id: NP_999454   ⟸   NM_214289
- UniProtKB: Q5XQS5 (UniProtKB/Swiss-Prot),   Q19B01 (UniProtKB/Swiss-Prot),   Q9GK29 (UniProtKB/Swiss-Prot),   O97562 (UniProtKB/Swiss-Prot),   A0A480XUE6 (UniProtKB/TrEMBL),   A0A480QLM5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000015752   ⟸   ENSSSCT00000016185
Ensembl Acc Id: ENSSSCP00000064413   ⟸   ENSSSCT00000084408


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000014833 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015050844 UniProtKB/TrEMBL
  ENSSSCG00030024297 UniProtKB/TrEMBL
  ENSSSCG00035035967 UniProtKB/TrEMBL
  ENSSSCG00040029057 UniProtKB/TrEMBL
  ENSSSCG00045022808 UniProtKB/TrEMBL
  ENSSSCG00050042146 UniProtKB/TrEMBL
  ENSSSCG00055026778 UniProtKB/TrEMBL
  ENSSSCG00070018943 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00090022935 UniProtKB/Swiss-Prot
  ENSSSCG00105009085 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000016185 ENTREZGENE
  ENSSSCT00000016185.5 UniProtKB/TrEMBL
  ENSSSCT00015068227.1 UniProtKB/TrEMBL
  ENSSSCT00030033832.1 UniProtKB/TrEMBL
  ENSSSCT00035047673.1 UniProtKB/TrEMBL
  ENSSSCT00035047680.1 UniProtKB/TrEMBL
  ENSSSCT00040039074.1 UniProtKB/TrEMBL
  ENSSSCT00045039020.1 UniProtKB/TrEMBL
  ENSSSCT00045039144.1 UniProtKB/TrEMBL
  ENSSSCT00050057262.1 UniProtKB/TrEMBL
  ENSSSCT00055052942.1 UniProtKB/TrEMBL
  ENSSSCT00070037381.1 UniProtKB/TrEMBL
  ENSSSCT00070037407.1 UniProtKB/Swiss-Prot
  ENSSSCT00070037422.1 UniProtKB/TrEMBL
  ENSSSCT00090040674 UniProtKB/Swiss-Prot
  ENSSSCT00105017975 UniProtKB/Swiss-Prot
Gene3D-CATH 1.50.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Mit_carrier UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mito_Metabolite_Transporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mitochondrial_sb/sol_carrier UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mt_carrier_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397549 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene UCP2 ENTREZGENE
PANTHER MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Mito_carr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MTUNCOUPLING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SOLCAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103506 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2C9F3B4_PIG UniProtKB/TrEMBL
  A0A480QLM5 ENTREZGENE, UniProtKB/TrEMBL
  A0A480XUE6 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1USK8_PIG UniProtKB/TrEMBL
  A0A8D0ZJ74_PIG UniProtKB/TrEMBL
  A1YVX1_PIG UniProtKB/TrEMBL
  D2CU47_PIG UniProtKB/TrEMBL
  O97562 ENTREZGENE
  Q0E5B0_PIG UniProtKB/TrEMBL
  Q0E5B1_PIG UniProtKB/TrEMBL
  Q19B01 ENTREZGENE
  Q56V26_PIG UniProtKB/TrEMBL
  Q5XQS5 ENTREZGENE
  Q9GK29 ENTREZGENE
  UCP2_PIG UniProtKB/Swiss-Prot
UniProt Secondary Q19B01 UniProtKB/Swiss-Prot
  Q5XQS5 UniProtKB/Swiss-Prot
  Q9GK29 UniProtKB/Swiss-Prot