HSP90AA1 (heat shock protein 90 alpha family class A member 1) - Rat Genome Database

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Gene: HSP90AA1 (heat shock protein 90 alpha family class A member 1) Sus scrofa
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Symbol: HSP90AA1
Name: heat shock protein 90 alpha family class A member 1
RGD ID: 13936954
Description: ENCODES a protein that exhibits ATP binding (ortholog); CTP binding (ortholog); dATP binding (ortholog); INVOLVED IN activation of innate immune response (ortholog); cardiac muscle cell apoptotic process (ortholog); cellular response to virus (ortholog); PARTICIPATES IN aldosterone signaling pathway; androgen signaling pathway; chaperone mediated autophagy pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); anaplastic large cell lymphoma (ortholog); Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); brush border membrane (ortholog); INTERACTS WITH glutathione; paraquat
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 90-kDa heat shock protein; heat shock protein HSP 90-alpha; HSP90; HSP90A; Hspca
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.27129,758,754 - 129,760,542 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
glutathione  (EXP)
paraquat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:8751722   PMID:9931505   PMID:14681463   PMID:17145712   PMID:17337508   PMID:18215117   PMID:19293389   PMID:20580074   PMID:20693398   PMID:22301074   PMID:27264891   PMID:27553861  
PMID:29935435   PMID:30032202   PMID:33242760  


Genomics

Comparative Map Data
HSP90AA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.27129,758,754 - 129,760,542 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSP90AA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814102,080,742 - 102,139,749 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14102,080,742 - 102,139,699 (-)EnsemblGRCh38hg38GRCh38
GRCh3714102,547,079 - 102,606,086 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614101,616,828 - 101,675,839 (-)NCBINCBI36Build 36hg18NCBI36
Build 3414101,617,144 - 101,623,135NCBI
Celera1482,601,564 - 82,660,582 (-)NCBICelera
Cytogenetic Map14q32.31NCBI
HuRef1482,725,979 - 82,785,051 (-)NCBIHuRef
CHM1_114102,484,935 - 102,543,941 (-)NCBICHM1_1
T2T-CHM13v2.01496,316,329 - 96,375,332 (-)NCBIT2T-CHM13v2.0
Hsp90aa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912110,657,470 - 110,662,829 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12110,657,039 - 110,669,162 (-)EnsemblGRCm39 Ensembl
GRCm3812110,691,036 - 110,696,395 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12110,690,605 - 110,702,728 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712111,929,246 - 111,934,605 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612111,138,843 - 111,144,202 (-)NCBIMGSCv36mm8
Celera12111,881,002 - 111,886,365 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.75NCBI
Hsp90aa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86135,523,604 - 135,529,687 (-)NCBIGRCr8
mRatBN7.26129,702,376 - 129,707,907 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6129,702,383 - 129,707,268 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6129,879,675 - 129,884,976 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06130,175,668 - 130,180,969 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06129,539,256 - 129,544,788 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06135,107,262 - 135,112,793 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6135,045,363 - 135,049,728 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl6135,107,271 - 135,112,775 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06144,182,009 - 144,187,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46135,413,616 - 135,419,147 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16135,419,806 - 135,425,334 (-)NCBI
Celera6127,272,361 - 127,277,892 (-)NCBICelera
Cytogenetic Map6q32NCBI
Hsp90aa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555381,469,544 - 1,475,019 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555381,469,544 - 1,475,010 (-)NCBIChiLan1.0ChiLan1.0
HSP90AA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215103,233,362 - 103,292,106 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114102,449,856 - 102,456,012 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01482,700,881 - 82,707,020 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114102,519,033 - 102,524,639 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14102,519,699 - 102,576,723 (-)Ensemblpanpan1.1panPan2
HSP90AA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1870,091,203 - 70,096,107 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl870,092,217 - 70,095,243 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha869,605,578 - 69,611,507 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0870,369,324 - 70,375,263 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl870,369,667 - 70,374,704 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1870,033,441 - 70,039,369 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0870,098,797 - 70,104,717 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0870,498,429 - 70,504,357 (-)NCBIUU_Cfam_GSD_1.0
Hsp90aa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086403,873,950 - 3,879,144 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936835316,767 - 321,990 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936835316,767 - 321,999 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSP90AA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12480,016,352 - 80,019,130 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2480,016,232 - 80,019,120 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605367,207,536 - 67,213,629 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsp90aa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247342,233,547 - 2,241,436 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247342,233,932 - 2,239,687 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Protein Domains
Histidine kinase/HSP90-like ATPase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000002535 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015010858 UniProtKB/TrEMBL
  ENSSSCG00025026657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00030037509 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00035056819 UniProtKB/TrEMBL
  ENSSSCG00040075632 UniProtKB/Swiss-Prot
  ENSSSCG00045009069 UniProtKB/TrEMBL
  ENSSSCG00050002300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00055020126 UniProtKB/TrEMBL
  ENSSSCG00060008700 UniProtKB/TrEMBL
  ENSSSCG00065071916 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00070011114 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000002815.5 UniProtKB/TrEMBL
  ENSSSCT00000045247.3 UniProtKB/TrEMBL
  ENSSSCT00000058545 ENTREZGENE
  ENSSSCT00000058545.3 UniProtKB/TrEMBL
  ENSSSCT00015014249.1 UniProtKB/TrEMBL
  ENSSSCT00025036060.1 UniProtKB/TrEMBL
  ENSSSCT00025036188.1 UniProtKB/TrEMBL
  ENSSSCT00025036343.1 UniProtKB/Swiss-Prot
  ENSSSCT00030052204.1 UniProtKB/TrEMBL
  ENSSSCT00030052232.1 UniProtKB/TrEMBL
  ENSSSCT00030052297.1 UniProtKB/Swiss-Prot
  ENSSSCT00035075945.1 UniProtKB/TrEMBL
  ENSSSCT00035075951.1 UniProtKB/TrEMBL
  ENSSSCT00040105032.1 UniProtKB/Swiss-Prot
  ENSSSCT00045015387.1 UniProtKB/TrEMBL
  ENSSSCT00045015453.1 UniProtKB/TrEMBL
  ENSSSCT00050002846.1 UniProtKB/TrEMBL
  ENSSSCT00050002867.1 UniProtKB/TrEMBL
  ENSSSCT00050002917.1 UniProtKB/Swiss-Prot
  ENSSSCT00055039731.1 UniProtKB/TrEMBL
  ENSSSCT00060011169.1 UniProtKB/TrEMBL
  ENSSSCT00065099486.1 UniProtKB/TrEMBL
  ENSSSCT00065099496.1 UniProtKB/Swiss-Prot
  ENSSSCT00070021734.1 UniProtKB/TrEMBL
  ENSSSCT00070021740.1 UniProtKB/TrEMBL
  ENSSSCT00070021746.1 UniProtKB/Swiss-Prot
  ENSSSCT00070021764.1 UniProtKB/TrEMBL
  ENSSSCT00070021768.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.790 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.230.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.11260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HATPase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_protein_90_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP90_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp90_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp90_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397028 UniProtKB/Swiss-Prot
NCBI Gene HSP90AA1 ENTREZGENE
PANTHER HEAT SHOCK PROTEIN HSP 90-ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11528 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HATPase_c_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Hsp90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HEATSHOCK90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HSP90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HATPase_c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF110942 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287AQK7_PIG UniProtKB/TrEMBL
  A0A287B8J5_PIG UniProtKB/TrEMBL
  A0A4X1TM49_PIG UniProtKB/TrEMBL
  A0A4X1TS03_PIG UniProtKB/TrEMBL
  A0A4X1TS11_PIG UniProtKB/TrEMBL
  A0A4X1TS37_PIG UniProtKB/TrEMBL
  A0A8D1R9S0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I8C3K7_PIG UniProtKB/TrEMBL
  HS90A_PIG UniProtKB/Swiss-Prot, ENTREZGENE