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Gene: MDH1 (malate dehydrogenase 1) Sus scrofa

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Symbol:

MDH1

Name:

malate dehydrogenase 1

RGD ID:

13920774

Description:

ENCODES a protein that exhibits NAD binding; L-malate dehydrogenase (NAD+) activity (ortholog); malate dehydrogenase activity (ortholog); INVOLVED IN malate metabolic process (ortholog); NAD metabolic process (ortholog); NADH metabolic process (ortholog); PARTICIPATES IN Leigh disease pathway; nicotinamide adenine dinucleotide metabolic pathway; primary hyperoxaluria type 2 pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); adult respiratory distress syndrome (ortholog); Bardet-Biedl syndrome (ortholog); FOUND IN cytosol; INTERACTS WITH deoxynivalenol

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

aromatic alpha-keto acid reductase; cytosolic malate dehydrogenase; KAR; malate dehydrogenase 1, NAD (soluble); malate dehydrogenase, cytoplasmic; MDH

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MDH1 (malate dehydrogenase 1)	HGNC	Inparanoid, NCBI, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Mdh1 (malate dehydrogenase 1, NAD (soluble))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Mdh1 (malate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mdh1 (malate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MDH1 (malate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MDH1 (malate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mdh1 (malate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MDH1 (malate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mdh1 (malate dehydrogenase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	78,244,999 - 78,268,600 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	78,247,229 - 78,263,085 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	82,274,663 - 82,280,460 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Liver Failure (ISO)

adult respiratory distress syndrome (ISO)

Bardet-Biedl syndrome (ISO)

Chemical and Drug Induced Liver Injury (ISO)

developmental and epileptic encephalopathy 88 (ISO)

Experimental Liver Cirrhosis (ISO)

hypertension (ISO)

Liver Injury (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

deoxynivalenol (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

malate metabolic process (IBA,IEA,ISO)

malate-aspartate shuttle (IEA)

NAD metabolic process (ISO)

NADH metabolic process (IBA,IEA,ISO)

NADP metabolic process (IEA)

oxaloacetate metabolic process (IBA,ISO)

tricarboxylic acid cycle (IBA,IEA)

Cellular Component

centrosome (IEA)

cytoplasm (IEA)

cytosol (IBA,IDA,IEA)

Molecular Function

hydroxyphenylpyruvate reductase activity (IEA)

L-malate dehydrogenase (NAD+) activity (IBA,IEA,ISO)

malate dehydrogenase activity (IEA,ISO)

NAD binding (IDA,ISO)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Leigh disease pathway (ISO)

nicotinamide adenine dinucleotide metabolic pathway (ISO)

primary hyperoxaluria type 2 pathway (ISO)

pyruvate decarboxylase deficiency pathway (ISO)

pyruvate dehydrogenase E1 deficiency pathway (ISO)

pyruvate kinase deficiency of red cells pathway (ISO)

pyruvate metabolic pathway (ISO)

References

Additional References at PubMed

PMID:2775751	PMID:3312200	PMID:3606987	PMID:8682322	PMID:10075524	PMID:14681463	PMID:17145712	PMID:19015805	PMID:21152271	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

MDH1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	78,244,999 - 78,268,600 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	78,247,229 - 78,263,085 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	82,274,663 - 82,280,460 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MDH1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	63,588,963 - 63,607,197 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	63,588,609 - 63,607,197 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	63,816,097 - 63,834,331 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	63,669,626 - 63,687,832 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	63,727,772 - 63,745,979	NCBI
Celera	2	63,661,163 - 63,679,336 (+)	NCBI		Celera
Cytogenetic Map	2	p15	NCBI
HuRef	2	63,556,773 - 63,575,326 (+)	NCBI		HuRef
CHM1_1	2	63,745,880 - 63,764,431 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	63,596,617 - 63,614,818 (+)	NCBI		T2T-CHM13v2.0

Mdh1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	21,506,692 - 21,521,934 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	21,506,692 - 21,522,367 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	21,556,692 - 21,571,934 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	21,556,692 - 21,572,367 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	21,456,695 - 21,471,937 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	21,456,790 - 21,471,832 (-)	NCBI		MGSCv36	mm8
Celera	11	23,704,959 - 23,720,201 (-)	NCBI		Celera
Cytogenetic Map	11	A3.1	NCBI
cM Map	11	13.89	NCBI

Mdh1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	99,831,934 - 99,847,227 (-)	NCBI		GRCr8
mRatBN7.2	14	95,630,625 - 95,645,920 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	95,630,306 - 95,645,925 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	99,982,791 - 99,997,990 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	101,223,133 - 101,238,332 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	97,696,668 - 97,711,868 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	106,378,349 - 106,393,642 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	106,378,942 - 106,393,670 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	106,449,337 - 106,463,995 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	102,259,130 - 102,273,788 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	102,278,343 - 102,292,999 (-)	NCBI
Celera	14	94,639,971 - 94,655,156 (-)	NCBI		Celera
Cytogenetic Map	14	q22	NCBI

Mdh1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	20,706,058 - 20,723,493 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	20,707,765 - 20,723,493 (-)	NCBI	ChiLan1.0	ChiLan1.0

MDH1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	62,789,858 - 62,808,152 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	62,793,808 - 62,812,102 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	63,658,933 - 63,677,257 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	64,785,132 - 64,803,631 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	64,785,132 - 64,803,631 (+)	Ensembl	panpan1.1		panPan2

MDH1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	63,316,818 - 63,334,556 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	63,316,831 - 63,361,735 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	63,205,783 - 63,223,532 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	64,325,732 - 64,343,477 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	64,325,748 - 64,393,190 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	64,008,394 - 64,026,100 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	64,316,618 - 64,334,341 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	64,609,207 - 64,626,872 (+)	NCBI		UU_Cfam_GSD_1.0

Mdh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	19,984,379 - 20,000,470 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936491	8,570,472 - 8,587,686 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936491	8,570,472 - 8,586,914 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MDH1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	43,406,502 - 43,425,525 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	43,406,499 - 43,425,095 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	68,435,625 - 68,454,293 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mdh1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624762	9,881,950 - 9,901,372 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624762	9,884,521 - 9,900,593 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in MDH1
353 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	hemolymphoid system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
10	4	23	3	2	5	14	12	23	3	6	3

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_213874	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK230576	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK238703	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK391973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK392418	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK400089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01019446	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M29463	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U44846	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000009164 ⟹ ENSSSCP00000008933

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	3	78,247,166 - 78,268,600 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000025091 ⟹ ENSSSCP00000027164

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	3	78,244,999 - 78,263,151 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000071972 ⟹ ENSSSCP00000065815

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	3	78,244,999 - 78,268,168 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000073046 ⟹ ENSSSCP00000064114

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	3	78,244,999 - 78,263,845 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000084364 ⟹ ENSSSCP00000062212

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	3	78,244,999 - 78,268,248 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000085792 ⟹ ENSSSCP00000063893

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	3	78,244,999 - 78,268,168 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000087195 ⟹ ENSSSCP00000062430

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	3	78,244,999 - 78,263,087 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000101739 ⟹ ENSSSCP00000076649

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	3	78,244,999 - 78,257,431 (-)	Ensembl

RefSeq Acc Id:

NM_213874 ⟹ NP_999039

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	3	78,247,229 - 78,263,085 (-)	NCBI

Sequence:

show sequence

ATGTCTGAACCAATCAGAGTGCTTGTGACTGGAGCAGCTGGTCAGATTGCATATTCACTGCTGT
ACAGTATTGGAAATGGATCTGTCTTCGGTAAAGACCAGCCTATCATCCTTGTGCTGTTGGATAT
CACCCCTATGATGGGTGTCCTGGATGGTGTCCTGATGGAGCTGCAGGACTGTGCCCTTCCCCTC
CTGAAAGATGTCATTGCAACAGATAAAGAAGAGATTGCCTTCAAAGACCTGGACGTTGCCATTC
TCGTGGGTTCCATGCCAAGAAGGGATGGCATGGAGAGGAAAGATTTACTCAAAGCAAATGTGAA
AATCTTCAAATGCCAGGGTGCTGCCTTGGACAAATATGCTAAGAAGTCAGTTAAGGTTATCGTG
GTGGGAAACCCAGCCAATACCAACTGCCTGACTGCCTCCAAGTCGGCTCCATCCATTCCCAAGG
AGAACTTCAGCTGCTTGACTCGTTTGGATCACAACCGAGCTAAAGCACAGATTGCTCTCAAACT
TGGTGTGACTTCTGATGATGTCAAGAATGTCATCATCTGGGGAAACCATTCCTCAACTCAGTAT
CCAGATGTCAACCATGCCAAGGTGAAACTGCAGGCAAAGGAAGTTGGTGTTTATGAAGCTGTGA
AGGATGACAGCTGGCTCAAGGGAGAGTTCATCACGACTGTGCAGCAGCGCGGTGCTGCTGTCAT
CAAGGCTCGAAAACTGTCCAGTGCAATGTCTGCGGCAAAAGCCATTTGTGACCATGTCAGAGAC
ATCTGGTTTGGAACCCCAGAGGGAGAGTTTGTGTCCATGGGCATTATCTCTGATGGCAACTCCT
ATGGTGTTCCTGATGATCTGCTCTACTCATTCCCTGTTACAATCAAGGATAAGACCTGGAAAAT
TGTTGAAGGTCTCCCTATTAATGATTTCTCTCGTGAGAAGATGGACCTCACTGCAAAGGAACTA
GCAGAAGAAAAAGAAACTGCATTTGAATTTCTTTCCTCTGCCTGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_999039	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA31072	(Get FASTA)	NCBI Sequence Viewer
	AAC48610	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000008933
	ENSSSCP00000008933.5
	ENSSSCP00000027164.3
	ENSSSCP00000062212.1
	ENSSSCP00000062430.2
	ENSSSCP00000063893.1
	ENSSSCP00000064114.2
	ENSSSCP00000065815.1
	ENSSSCP00000076649.1
	ENSSSCP00015026700.1
	ENSSSCP00015026794.1
	ENSSSCP00015026843.1
	ENSSSCP00025010511.1
	ENSSSCP00025010522.1
	ENSSSCP00025010537.1
	ENSSSCP00030001739.1
	ENSSSCP00030001751.1
	ENSSSCP00030001760.1
	ENSSSCP00035036265.1
	ENSSSCP00035036275.1
	ENSSSCP00035036282.1
	ENSSSCP00040000351.1
	ENSSSCP00040000357.1
	ENSSSCP00045024175.1
	ENSSSCP00045024253.1
	ENSSSCP00045024317.1
	ENSSSCP00055032460.1
	ENSSSCP00055032609.1
	ENSSSCP00055032681.1
	ENSSSCP00060027214.1
	ENSSSCP00060027217.1
	ENSSSCP00060027222.1
	ENSSSCP00065034720.1
	ENSSSCP00065034726.1
	ENSSSCP00065034729.1
	ENSSSCP00070051692.1
	ENSSSCP00070051693.1
	ENSSSCP00070051709.1
	ENSSSCP00070051711.1
	ENSSSCP00070051712.1
	ENSSSCP00070051717.1
	ENSSSCP00085015811
	ENSSSCP00090021887
	ENSSSCP00105007769
	ENSSSCP00110001925
	ENSSSCP00130029009
GenBank Protein	P11708	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_999039 ⟸ NM_213874

- UniProtKB:

Q29560 (UniProtKB/Swiss-Prot), P11708 (UniProtKB/Swiss-Prot), A0A480JV95 (UniProtKB/TrEMBL), A0A8D1BFV6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPL
LKDVIATDKEEIAFKDLDVAILVGSMPRRDGMERKDLLKANVKIFKCQGAALDKYAKKSVKVIV
VGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTSDDVKNVIIWGNHSSTQY
PDVNHAKVKLQAKEVGVYEAVKDDSWLKGEFITTVQQRGAAVIKARKLSSAMSAAKAICDHVRD
IWFGTPEGEFVSMGIISDGNSYGVPDDLLYSFPVTIKDKTWKIVEGLPINDFSREKMDLTAKEL
AEEKETAFEFLSSA

hide sequence

Ensembl Acc Id:

ENSSSCP00000027164 ⟸ ENSSSCT00000025091

Ensembl Acc Id:

ENSSSCP00000008933 ⟸ ENSSSCT00000009164

Ensembl Acc Id:

ENSSSCP00000062212 ⟸ ENSSSCT00000084364

Ensembl Acc Id:

ENSSSCP00000063893 ⟸ ENSSSCT00000085792

Ensembl Acc Id:

ENSSSCP00000065815 ⟸ ENSSSCT00000071972

Ensembl Acc Id:

ENSSSCP00000062430 ⟸ ENSSSCT00000087195

Ensembl Acc Id:

ENSSSCP00000064114 ⟸ ENSSSCT00000073046

Ensembl Acc Id:

ENSSSCP00000076649 ⟸ ENSSSCT00000101739

Protein Domains

Lactate/malate dehydrogenase C-terminal Lactate/malate dehydrogenase N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000025751	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSSSCG00015049456	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSSSCG00025018263	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSSSCG00030003287	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSSSCG00035064600	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSSSCG00040001107	UniProtKB/TrEMBL
	ENSSSCG00045020269	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSSSCG00055020633	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSSSCG00060046704	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSSSCG00065058308	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSSSCG00070030148	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSSSCG00085012240	UniProtKB/Swiss-Prot
	ENSSSCG00090019826	UniProtKB/Swiss-Prot
	ENSSSCG00105005152	UniProtKB/Swiss-Prot
	ENSSSCG00110001173	UniProtKB/Swiss-Prot
	ENSSSCG00130021213	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSSSCT00000009164	ENTREZGENE
	ENSSSCT00000009164.5	UniProtKB/TrEMBL
	ENSSSCT00000025091.4	UniProtKB/TrEMBL
	ENSSSCT00000071972.2	UniProtKB/TrEMBL
	ENSSSCT00000073046.2	UniProtKB/TrEMBL
	ENSSSCT00000084364.1	UniProtKB/Swiss-Prot
	ENSSSCT00000085792.2	UniProtKB/TrEMBL
	ENSSSCT00000087195.2	UniProtKB/TrEMBL
	ENSSSCT00000101739.1	UniProtKB/TrEMBL
	ENSSSCT00015066598.1	UniProtKB/Swiss-Prot
	ENSSSCT00015066818.1	UniProtKB/Swiss-Prot
	ENSSSCT00015066917.1	UniProtKB/TrEMBL
	ENSSSCT00025024872.1	UniProtKB/Swiss-Prot
	ENSSSCT00025024902.1	UniProtKB/Swiss-Prot
	ENSSSCT00025024932.1	UniProtKB/TrEMBL
	ENSSSCT00030004373.1	UniProtKB/Swiss-Prot
	ENSSSCT00030004398.1	UniProtKB/Swiss-Prot
	ENSSSCT00030004423.1	UniProtKB/TrEMBL
	ENSSSCT00035086982.1	UniProtKB/Swiss-Prot
	ENSSSCT00035086994.1	UniProtKB/Swiss-Prot
	ENSSSCT00035087008.1	UniProtKB/TrEMBL
	ENSSSCT00040001403.1	UniProtKB/TrEMBL
	ENSSSCT00040001421.1	UniProtKB/TrEMBL
	ENSSSCT00045034851.1	UniProtKB/Swiss-Prot
	ENSSSCT00045034956.1	UniProtKB/Swiss-Prot
	ENSSSCT00045035045.1	UniProtKB/TrEMBL
	ENSSSCT00055040807.1	UniProtKB/Swiss-Prot
	ENSSSCT00055040984.1	UniProtKB/Swiss-Prot
	ENSSSCT00055041074.1	UniProtKB/TrEMBL
	ENSSSCT00060063466.1	UniProtKB/Swiss-Prot
	ENSSSCT00060063473.1	UniProtKB/Swiss-Prot
	ENSSSCT00060063486.1	UniProtKB/TrEMBL
	ENSSSCT00065079812.1	UniProtKB/Swiss-Prot
	ENSSSCT00065079828.1	UniProtKB/Swiss-Prot
	ENSSSCT00065079831.1	UniProtKB/TrEMBL
	ENSSSCT00070060652.1	UniProtKB/Swiss-Prot
	ENSSSCT00070060653.1	UniProtKB/TrEMBL
	ENSSSCT00070060669.1	UniProtKB/TrEMBL
	ENSSSCT00070060671.1	UniProtKB/TrEMBL
	ENSSSCT00070060672.1	UniProtKB/Swiss-Prot
	ENSSSCT00070060677.1	UniProtKB/TrEMBL
	ENSSSCT00085023006	UniProtKB/Swiss-Prot
	ENSSSCT00090035135	UniProtKB/Swiss-Prot
	ENSSSCT00105010568	UniProtKB/Swiss-Prot
	ENSSSCT00110002488	UniProtKB/Swiss-Prot
	ENSSSCT00130041178	UniProtKB/Swiss-Prot
Gene3D-CATH	3.90.110.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NAD(P)-binding Rossmann-like Domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	L-lactate/malate_DH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Lactate/malate_DH_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Lactate/malate_DH_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Lactate_DH/Glyco_Ohase_4_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Malate_DH_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Malate_DH_NAD-dep_euk	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Malate_DH_type2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	ssc:396894	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	MDH1	ENTREZGENE
PANTHER	PTHR23382	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Ldh_1_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ldh_1_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF	Lac_mal_DH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	MDH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF56327	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A480JV95	ENTREZGENE, UniProtKB/TrEMBL
	A0A4X1W5L3_PIG	UniProtKB/TrEMBL
	A0A4X1WBE3_PIG	UniProtKB/TrEMBL
	A0A4X1WCL2_PIG	UniProtKB/TrEMBL
	A0A4X1WCL6_PIG	UniProtKB/TrEMBL
	A0A5G2QFC2_PIG	UniProtKB/TrEMBL
	A0A5G2QP21_PIG	UniProtKB/TrEMBL
	A0A5G2QP84_PIG	UniProtKB/TrEMBL
	A0A5G2QPX2_PIG	UniProtKB/TrEMBL
	A0A5S8KKT9_PIG	UniProtKB/TrEMBL
	A0A8D1AXH1_PIG	UniProtKB/TrEMBL
	A0A8D1BFV6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8W4FBF0_PIG	UniProtKB/TrEMBL
	MDHC_PIG	UniProtKB/Swiss-Prot, ENTREZGENE
	Q29560	ENTREZGENE
UniProt Secondary	A0A900PKR1	UniProtKB/TrEMBL
	Q29560	UniProtKB/Swiss-Prot
VGNC ID	VGNC:109461	ENTREZGENE

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InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB