CDKN1B (cyclin dependent kinase inhibitor 1B) - Rat Genome Database

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Gene: CDKN1B (cyclin dependent kinase inhibitor 1B) Sus scrofa
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Symbol: CDKN1B
Name: cyclin dependent kinase inhibitor 1B
RGD ID: 13906352
Description: ENCODES a protein that exhibits cyclin-dependent protein kinase activating kinase regulator activity (ortholog); Hsp70 protein binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN apoptotic process (ortholog); cellular response to antibiotic (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN forkhead class A signaling pathway; G1/S transition pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); acute myeloid leukemia (ortholog); autosomal dominant intellectual developmental disorder 6 (ortholog); FOUND IN protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cyclin-dependent kinase inhibitor 1B; p27Kip1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl559,731,206 - 59,735,831 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1559,731,224 - 59,735,831 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
acute myeloid leukemia  (ISO)
autosomal dominant intellectual developmental disorder 6  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
cataract  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chloracne  (ISO)
chronic myeloid leukemia  (ISO)
Diabetic Nephropathies  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Fallopian Tube Neoplasms  (ISO)
Familial Prostate Cancer  (ISO)
Fibrosis  (ISO)
glaucoma  (ISO)
Helicobacter Infections  (ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hyperthyroidism  (ISO)
infertility  (ISO)
influenza  (ISO)
Intestinal Neoplasms  (ISO)
Kidney Neoplasms  (ISO)
Left Ventricular Hypertrophy  (ISO)
Leukoencephalopathies  (ISO)
Leydig cell tumor  (ISO)
Liver Neoplasms  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
membranoproliferative glomerulonephritis  (ISO)
membranous glomerulonephritis  (ISO)
Mesothelioma  (ISO)
multiple endocrine neoplasia  (ISO)
multiple endocrine neoplasia type 4  (ISO)
myelodysplastic syndrome  (ISO)
myocardial infarction  (ISO)
nephroblastoma  (ISO)
neuroendocrine tumor  (ISO)
obesity  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
paraganglioma  (ISO)
pheochromocytoma  (ISO)
pituitary adenoma  (ISO)
Pituitary Neoplasms  (ISO)
primary hyperparathyroidism  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
rectal benign neoplasm  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
sciatic neuropathy  (ISO)
senile cataract  (ISO)
Sezary's disease  (ISO)
Spinal Cord Injuries  (ISO)
Stomach Neoplasms  (ISO)
Testicular Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Uterine Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA,ISO)
autophagic cell death  (IEA)
cellular response to antibiotic  (IEA,ISO)
cellular response to hypoxia  (ISO)
cellular response to lithium ion  (IEA,ISO)
epithelial cell apoptotic process  (IEA,ISO)
epithelial cell proliferation involved in prostate gland development  (IEA,ISO)
G1/S transition of mitotic cell cycle  (IBA,IEA)
heart development  (IEA)
inner ear development  (IEA,ISO)
negative regulation of cardiac muscle tissue regeneration  (IEA)
negative regulation of cell growth  (IEA)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of cyclin-dependent protein kinase activity  (ISO)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of epithelial cell apoptotic process  (IEA,ISO)
negative regulation of epithelial cell proliferation  (IBA,IEA,ISO)
negative regulation of epithelial cell proliferation involved in prostate gland development  (IEA,ISO)
negative regulation of kinase activity  (ISO)
negative regulation of mitotic cell cycle  (IBA)
negative regulation of phosphorylation  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
Notch signaling pathway  (IEA,ISO)
nuclear export  (IEA)
obsolete cellular response to organic cyclic compound  (IEA,ISO)
placenta development  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of cellular process  (ISO)
positive regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
positive regulation of microtubule polymerization  (IEA,ISO)
positive regulation of protein catabolic process  (IEA,ISO)
positive regulation of protein phosphorylation  (ISO)
potassium ion transport  (IEA,ISO)
regulation of cell cycle  (IEA)
regulation of cell cycle G1/S phase transition  (IEA)
regulation of cell migration  (IEA,ISO)
regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
regulation of exit from mitosis  (IEA,ISO)
regulation of G1/S transition of mitotic cell cycle  (IEA)
regulation of lens fiber cell differentiation  (IEA,ISO)
regulation of mitotic cell cycle  (IEA,ISO)
response to amino acid  (ISO)
response to cadmium ion  (ISO)
response to estradiol  (ISO)
response to genistein  (ISO)
response to glucose  (ISO)
response to hypoxia  (ISO)
response to peptide hormone  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of sound  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:8973354   PMID:9349726   PMID:10542271   PMID:11115398   PMID:15087469   PMID:17868934   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CDKN1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl559,731,206 - 59,735,831 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1559,731,224 - 59,735,831 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CDKN1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381212,717,368 - 12,722,369 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1212,685,498 - 12,722,369 (+)EnsemblGRCh38hg38GRCh38
GRCh371212,870,302 - 12,875,303 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361212,761,576 - 12,766,570 (+)NCBINCBI36Build 36hg18NCBI36
Build 341212,761,575 - 12,766,569NCBI
Celera1218,018,828 - 18,023,831 (+)NCBICelera
Cytogenetic Map12p13.1NCBI
HuRef1212,639,893 - 12,644,900 (+)NCBIHuRef
CHM1_11212,835,677 - 12,840,684 (+)NCBICHM1_1
T2T-CHM13v2.01212,590,905 - 12,595,906 (+)NCBIT2T-CHM13v2.0
Cdkn1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396134,897,364 - 134,902,488 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6134,897,364 - 134,902,476 (+)EnsemblGRCm39 Ensembl
GRCm386134,920,401 - 134,925,525 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6134,920,401 - 134,925,513 (+)EnsemblGRCm38mm10GRCm38
MGSCv376134,870,419 - 134,875,543 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366134,886,110 - 134,889,751 (+)NCBIMGSCv36mm8
Celera6137,877,174 - 137,882,301 (+)NCBICelera
Cytogenetic Map6G1NCBI
cM Map665.77NCBI
Cdkn1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84169,491,273 - 169,496,500 (+)NCBIGRCr8
mRatBN7.24167,760,067 - 167,765,177 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4167,760,181 - 167,764,982 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4174,053,581 - 174,058,382 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04169,836,661 - 169,841,462 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04168,460,545 - 168,465,348 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04168,689,043 - 168,694,159 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4168,689,163 - 168,693,964 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04232,962,218 - 232,967,323 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44171,841,705 - 171,846,506 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14172,086,631 - 172,091,508 (+)NCBI
Celera4156,357,827 - 156,362,628 (+)NCBICelera
Cytogenetic Map4q43NCBI
Cdkn1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554139,615,542 - 9,620,542 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554139,615,542 - 9,620,542 (+)NCBIChiLan1.0ChiLan1.0
CDKN1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21018,185,665 - 18,190,870 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11218,182,491 - 18,187,630 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01212,742,258 - 12,747,404 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11213,120,306 - 13,125,541 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1213,120,306 - 13,125,541 (+)Ensemblpanpan1.1panPan2
CDKN1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12733,609,154 - 33,613,558 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2733,611,760 - 33,612,906 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2712,832,036 - 12,833,182 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02733,916,284 - 33,921,570 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2733,916,288 - 33,921,501 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12733,812,098 - 33,813,242 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02733,762,117 - 33,763,263 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02712,566,389 - 12,567,535 (+)NCBIUU_Cfam_GSD_1.0
Cdkn1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494594,845,531 - 94,850,821 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365874,572,728 - 4,578,461 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365874,573,166 - 4,578,480 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDKN1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11112,612,064 - 12,617,228 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1112,612,079 - 12,617,531 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606922,701,998 - 22,707,306 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdkn1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475225,203,474 - 25,207,114 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475225,202,474 - 25,207,107 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CDKN1B
27 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000040352   ⟹   ENSSSCP00000045015
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl559,731,206 - 59,735,831 (-)Ensembl
RefSeq Acc Id: NM_214316   ⟹   NP_999481
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1559,731,224 - 59,735,831 (-)NCBI
Sequence:
RefSeq Acc Id: NP_999481   ⟸   NM_214316
- UniProtKB: Q9BDC3 (UniProtKB/TrEMBL),   A0A4X1V4V1 (UniProtKB/TrEMBL),   Q5KTZ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000045015   ⟸   ENSSSCT00000040352

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000037144 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015052413 UniProtKB/TrEMBL
  ENSSSCG00025039653 UniProtKB/TrEMBL
  ENSSSCG00030046903 UniProtKB/TrEMBL
  ENSSSCG00035053604 UniProtKB/TrEMBL
  ENSSSCG00040027399 UniProtKB/TrEMBL
  ENSSSCG00045005056 UniProtKB/TrEMBL
  ENSSSCG00050038509 UniProtKB/TrEMBL
  ENSSSCG00055007665 UniProtKB/TrEMBL
  ENSSSCG00060057911 UniProtKB/TrEMBL
  ENSSSCG00065070497 UniProtKB/TrEMBL
  ENSSSCG00070021885 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000040352 ENTREZGENE
  ENSSSCT00000040352.2 UniProtKB/TrEMBL
  ENSSSCT00015069872.1 UniProtKB/TrEMBL
  ENSSSCT00025053886.1 UniProtKB/TrEMBL
  ENSSSCT00030065419.1 UniProtKB/TrEMBL
  ENSSSCT00035071509.1 UniProtKB/TrEMBL
  ENSSSCT00040036680.1 UniProtKB/TrEMBL
  ENSSSCT00045008432.1 UniProtKB/TrEMBL
  ENSSSCT00050051953.1 UniProtKB/TrEMBL
  ENSSSCT00055014990.1 UniProtKB/TrEMBL
  ENSSSCT00060078910.1 UniProtKB/TrEMBL
  ENSSSCT00065096831.1 UniProtKB/TrEMBL
  ENSSSCT00070043497.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.365.10 UniProtKB/TrEMBL
InterPro CDI UniProtKB/TrEMBL
  CDI_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:397584 UniProtKB/TrEMBL
NCBI Gene CDKN1B ENTREZGENE
PANTHER CYCLIN-DEPENDENT KINASE INHIBITOR 1 UniProtKB/TrEMBL
  PTHR10265:SF9 UniProtKB/TrEMBL
Pfam CDI UniProtKB/TrEMBL
UniProt A0A4X1V4V1 ENTREZGENE, UniProtKB/TrEMBL
  Q5KTZ8 ENTREZGENE, UniProtKB/TrEMBL
  Q9BDC3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:86515 ENTREZGENE