ADAM30 (ADAM metallopeptidase domain 30)

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Gene: ADAM30 (ADAM metallopeptidase domain 30) Sus scrofa

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Symbol:

ADAM30

Name:

ADAM metallopeptidase domain 30

RGD ID:

13883544

Description:

ENCODES a protein that exhibits metal ion binding (inferred); metalloendopeptidase activity (inferred); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH Hajdu-Cheney syndrome (ortholog); PHGDH deficiency (ortholog); FOUND IN external side of plasma membrane (inferred); membrane (inferred); sperm head plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

disintegrin and metalloproteinase domain-containing protein 30

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	101,314,710 - 101,316,893 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	101,314,710 - 101,316,974 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	111,215,977 - 111,218,587 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Hajdu-Cheney syndrome (ISO)

PHGDH deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proteolysis (IEA)

Cellular Component

external side of plasma membrane (IEA)

membrane (IEA)

sperm head plasma membrane (IEA)

Molecular Function

metal ion binding (IEA)

metalloendopeptidase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ADAM30
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	101,314,710 - 101,316,893 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	101,314,710 - 101,316,974 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	111,215,977 - 111,218,587 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADAM30
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	119,893,533 - 119,896,515 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	119,893,533 - 119,896,515 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	120,436,156 - 120,439,138 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	120,237,679 - 120,240,636 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	120,148,198 - 120,151,155	NCBI
Celera	1	118,666,878 - 118,669,835 (-)	NCBI		Celera
Cytogenetic Map	1	p12	ENTREZGENE
HuRef	1	118,294,693 - 118,297,684 (-)	NCBI		HuRef
CHM1_1	1	120,551,650 - 120,554,641 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	119,906,790 - 119,909,772 (-)	NCBI		T2T-CHM13v2.0

Adam30
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	98,067,950 - 98,071,485 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	98,067,946 - 98,071,485 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	98,160,634 - 98,164,169 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	98,160,630 - 98,164,169 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	97,964,735 - 97,967,096 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	98,246,217 - 98,248,578 (+)	NCBI		MGSCv36	mm8
Celera	3	99,560,033 - 99,562,394 (+)	NCBI		Celera
Cytogenetic Map	3	F2.2	NCBI
cM Map	3	42.63	NCBI

Adam30
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	188,440,918 - 188,444,358 (+)	NCBI		GRCr8
mRatBN7.2	2	185,752,183 - 185,755,623 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	185,752,072 - 185,755,599 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	193,400,568 - 193,404,009 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	191,208,751 - 191,212,192 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	186,033,146 - 186,036,587 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	200,328,498 - 200,331,938 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	200,328,387 - 200,331,914 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	219,804,507 - 219,807,947 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	192,997,466 - 193,000,906 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	178,242,634 - 178,246,074 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

ADAM30
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	112,535,910 - 112,542,053 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	112,138,361 - 112,144,504 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	82,630,734 - 82,633,448 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	117,628,391 - 117,631,178 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	117,628,573 - 117,631,026 (+)	Ensembl	panpan1.1		panPan2

LOC100682600
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	56,768,324 - 56,772,594 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	56,399,802 - 56,401,549 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	57,649,632 - 57,651,326 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	17	56,686,190 - 56,687,884 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	56,711,459 - 56,713,150 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	57,328,617 - 57,330,326 (-)	NCBI		UU_Cfam_GSD_1.0

Adam30
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	2,557,503 - 2,560,461 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936872	578,616 - 580,853 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADAM30
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	13,887,509 - 13,890,543 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	13,887,666 - 13,890,095 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	16,517,240 - 16,520,650 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in ADAM30
20 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	mesenchyme
2	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_001926562	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000024	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU468974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000007354 ⟹ ENSSSCP00000007159

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	4	101,314,710 - 101,316,893 (+)	Ensembl

RefSeq Acc Id:

XM_001926562 ⟹ XP_001926597

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	4	101,314,710 - 101,316,974 (+)	NCBI

Sequence:

show sequence

ATGAGGTCAGTGAGGACCTTCCTCTCCCAAGGCCCTTTGCTCCCCACATTAGTCCTGGTGGTGC
TCCTTGTTGACTCCCTTGGCAAGGATTTAAATCTCCCCCCTGGGTGGGACTTTGACTCCTATGA
AATCACCATCCCCAAGAAGCTGAGCTTCCGGGGAGGGGTCCAGGGTGTAGCCAAGCACGTGTCC
TACCTCCTGCAAGTAAAAGGCAAGAGCCATGTTCTCCACCTGTGGCCCAAGAGATTTCTACTGC
CCCGGAATCTGCAGGTTTTCTCCTTCACAGAACTGGGGAGACTCTGGGAGGATCACCCTTACAT
ACCCAGCAACTGCAACTATATGGGCTTGGTTGAAGGAAATCAGGATTCTGAAGCTACTTTAAGT
ACCTGCATGGGGGTTCTGCGGGGCATATTGAAAATTGATGCCAGTCATTACCAAATCGAACCCC
TCAAGGCTTCTTCCAGTTTTGAACATGTCATATATCTCCTGAAGAAAGAGGAGGAATTTCCCCA
TCAGATCTGCGGCTTAACTGATGATGAAACATTAAAGCAGATGGCCCAGCATAAGAACGTGGCC
CGGATAAGTGACTTTTCTCAGTCGTATATGCACCAAAAATACTTGGAATTAGCCTTGGTCTTTG
ATCACAGTAGATATATATTTTTAAACTCCAATCTTTCTCGAGTCATAAATGATGCCATTCTTCT
GTCTTCTATTATGGACACTTACTTTCAAGATGTCCGTATGAGAATACATCTAACAGGTGTTGAA
GTATGGACAGATGAAGACAAAATAAGACTTACGTATCCAAAGTTAGAACAAGTTTTAGGCCAGT
TTATGGTATACAGAACAAGTGTACTAAATGCTCGGTTTCCAGTAGACTGGATACATCTGTACCT
TAAAAGAAATTATTCTGATTCACTCGCACTGTACTTGGGAAATGTATGTACTAAGTTTCATGCT
GGATCTACAAGTGTTTTTCCAGATGTAAATGTTCTTGGACCTGCCACTTGGTCCACTCATGCAC
TGGGCCATGGTGTGGGAATGCGCCATGATGAAGAATATTGCCAATGTAAGGGAAGGCATAGTTG
CATCATGGGCAGTGGTCAATATGGGTTTAGTAATTGTAGTTATGCCCATTTTTTTGCACACGTA
TATTCAGGAGCAAAGTGTCTAACTAATATCCCAGAACTAAGTTATGTAGTTAAGAGATGCGGAA
ACAAAATTGTGGAAGAAGACGAAGAATGTGATTGTGGTTCAATAGAGGACTGTAAAAATGACCA
CTGTTGTCAACCAGATTGTAAATTCAAACATGGTGCTAAGTGTAGCATTGGGCTTTGCTGTCAT
AAATGCCAATTTCGTCCATCTGGATATAAATGTAGGCTGGAAGAAAATGAATGTGACCTTGCAG
AGTACTGCAATGGGACCTCAGCACTCTGCCCAAGTGACACTTATAAGCAGGATGGAACTCCTTG
CAAGGATGAAGCCCATTGTTTCAACAAGGCTTGCCAATCCAGATTTATGCAGTGCCAAAAAATA
TTTGGACCTGATGCCACAGAGGCTCCTCTTCAGTGCTATGTTGCTATTAATGTAATAGGTGACC
AGTATGGGAACTGTGGTATTTCAGGAGTTCGTGAATATAGAAAGTGTAACAGGAGAAATGCATT
ATGTGGCAGGATACAGTGTATAAATGTCAATACTATCCCCGATATGCCAGATCATACTATTTTA
ATTTCCACTCATCTCCACGATGAAAATCTCAAGTGCTGGGGCATAGGCTACCATCCAGCCATGG
TACCTATGGGGTTGCCTGACCTGGGTGTGGTAAGCGATGGTACTTCCTGTGGTAGGAACAACGT
ATGTTTTAATAGAAATTGTGTGAATAGCTCAGTCCTGAAGTTTGACTGTTTTCCTGAGAAGTGC
AACCACCGAGGCGTTTGTAACAATAACAAAAACTGCCACTGCATGTATGGCTGGTCCCCTCCGT
TGTGTGAGGAGTTAGGGTATGGAGGAAGCATTGATAGCGGGCCACCAGGACCACTAAAAGAGGG
GGTACCCACCTCGGTTCAGGTTGTGTCCCTTATGTTTGTACGCCTTATTTTCTTAATTATCTCA
GTGATTGTTGTGTTTTTCAAGAAAATCATAGGAAACTTTAAAACCCAAAGAGAAAGTAACCCCA
CCACTTAAATCTGGAGCAATTCAAGGCAAAAAAAAAGGTCAAGAAGACACAAAAGTAATCAAGC
AATCTCTCTATAACACAGGGTCATA

hide sequence

Protein Sequences


Protein RefSeqs	XP_001926597	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000007159
	ENSSSCP00000007159.2
	ENSSSCP00015017653.1
	ENSSSCP00025028795.1
	ENSSSCP00030044859.1
	ENSSSCP00035003747.1
	ENSSSCP00040032659.1
	ENSSSCP00045020376.1
	ENSSSCP00050005612.1
	ENSSSCP00055009297.1
	ENSSSCP00060008304.1
	ENSSSCP00065030657.1
	ENSSSCP00070012973.1

RefSeq Acc Id:

XP_001926597 ⟸ XM_001926562

- UniProtKB:

F1SB05 (UniProtKB/TrEMBL), A0A4X1TA74 (UniProtKB/TrEMBL), A0A8D0NIG7 (UniProtKB/TrEMBL), A0A8D1Z248 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRSVRTFLSQGPLLPTLVLVVLLVDSLGKDLNLPPGWDFDSYEITIPKKLSFRGGVQGVAKHVS
YLLQVKGKSHVLHLWPKRFLLPRNLQVFSFTELGRLWEDHPYIPSNCNYMGLVEGNQDSEATLS
TCMGVLRGILKIDASHYQIEPLKASSSFEHVIYLLKKEEEFPHQICGLTDDETLKQMAQHKNVA
RISDFSQSYMHQKYLELALVFDHSRYIFLNSNLSRVINDAILLSSIMDTYFQDVRMRIHLTGVE
VWTDEDKIRLTYPKLEQVLGQFMVYRTSVLNARFPVDWIHLYLKRNYSDSLALYLGNVCTKFHA
GSTSVFPDVNVLGPATWSTHALGHGVGMRHDEEYCQCKGRHSCIMGSGQYGFSNCSYAHFFAHV
YSGAKCLTNIPELSYVVKRCGNKIVEEDEECDCGSIEDCKNDHCCQPDCKFKHGAKCSIGLCCH
KCQFRPSGYKCRLEENECDLAEYCNGTSALCPSDTYKQDGTPCKDEAHCFNKACQSRFMQCQKI
FGPDATEAPLQCYVAINVIGDQYGNCGISGVREYRKCNRRNALCGRIQCINVNTIPDMPDHTIL
ISTHLHDENLKCWGIGYHPAMVPMGLPDLGVVSDGTSCGRNNVCFNRNCVNSSVLKFDCFPEKC
NHRGVCNNNKNCHCMYGWSPPLCEELGYGGSIDSGPPGPLKEGVPTSVQVVSLMFVRLIFLIIS
VIVVFFKKIIGNFKTQRESNPTT

hide sequence

Ensembl Acc Id:

ENSSSCP00000007159 ⟸ ENSSSCT00000007354

Protein Domains

Disintegrin EGF-like Peptidase M12B

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000006713	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00015033736	UniProtKB/TrEMBL
	ENSSSCG00025049427	UniProtKB/TrEMBL
	ENSSSCG00030069579	UniProtKB/TrEMBL
	ENSSSCG00035008783	UniProtKB/TrEMBL
	ENSSSCG00040056097	UniProtKB/TrEMBL
	ENSSSCG00045017296	UniProtKB/TrEMBL
	ENSSSCG00050010112	UniProtKB/TrEMBL
	ENSSSCG00055006063	UniProtKB/TrEMBL
	ENSSSCG00060015260	UniProtKB/TrEMBL
	ENSSSCG00065051352	UniProtKB/TrEMBL
	ENSSSCG00070008111	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000007354	ENTREZGENE
	ENSSSCT00000007354.2	UniProtKB/TrEMBL
	ENSSSCT00015044660.1	UniProtKB/TrEMBL
	ENSSSCT00025067289.1	UniProtKB/TrEMBL
	ENSSSCT00030097343.1	UniProtKB/TrEMBL
	ENSSSCT00035010985.1	UniProtKB/TrEMBL
	ENSSSCT00040076007.1	UniProtKB/TrEMBL
	ENSSSCT00045029408.1	UniProtKB/TrEMBL
	ENSSSCT00050013599.1	UniProtKB/TrEMBL
	ENSSSCT00055011743.1	UniProtKB/TrEMBL
	ENSSSCT00060020299.1	UniProtKB/TrEMBL
	ENSSSCT00065070329.1	UniProtKB/TrEMBL
	ENSSSCT00070015681.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.390.10	UniProtKB/TrEMBL
	4.10.70.10	UniProtKB/TrEMBL
InterPro	ADAM_Cys-rich	UniProtKB/TrEMBL
	Disintegrin_CS	UniProtKB/TrEMBL
	Disintegrin_dom	UniProtKB/TrEMBL
	Disintegrin_dom_sf	UniProtKB/TrEMBL
	EGF-like_dom	UniProtKB/TrEMBL
	MetalloPept_cat_dom_sf	UniProtKB/TrEMBL
	Peptidase_M12B	UniProtKB/TrEMBL
	Peptidase_M12B_N	UniProtKB/TrEMBL
	Reprolysin_adamalysin	UniProtKB/TrEMBL
KEGG Report	ssc:100156604	UniProtKB/TrEMBL
NCBI Gene	ADAM30	ENTREZGENE
PANTHER	ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN	UniProtKB/TrEMBL
	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 30	UniProtKB/TrEMBL
Pfam	ADAM_CR	UniProtKB/TrEMBL
	Disintegrin	UniProtKB/TrEMBL
	Pep_M12B_propep	UniProtKB/TrEMBL
	Reprolysin	UniProtKB/TrEMBL
PRINTS	DISINTEGRIN	UniProtKB/TrEMBL
PROSITE	ADAM_MEPRO	UniProtKB/TrEMBL
	DISINTEGRIN_1	UniProtKB/TrEMBL
	DISINTEGRIN_2	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
SMART	ACR	UniProtKB/TrEMBL
	DISIN	UniProtKB/TrEMBL
Superfamily-SCOP	Metalloproteases ('zincins'), catalytic domain	UniProtKB/TrEMBL
	SSF57552	UniProtKB/TrEMBL
UniProt	A0A4X1TA74	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D0NIG7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1Z248	ENTREZGENE, UniProtKB/TrEMBL
	F1SB05	ENTREZGENE
UniProt Secondary	F1SB05	UniProtKB/TrEMBL
VGNC ID	VGNC:85069	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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