ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide) - Rat Genome Database

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Gene: ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide) Sus scrofa
Analyze
Symbol: ADH4
Name: alcohol dehydrogenase 4 (class II), pi polypeptide
RGD ID: 13881002
Description: ENCODES a protein that exhibits alcohol dehydrogenase (NAD+) activity (inferred); aldose reductase (NADPH) activity (inferred); all-trans retinal binding (inferred); INVOLVED IN alcohol catabolic process (ortholog); aldehyde metabolic process (ortholog); ethanol metabolic process (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); autism spectrum disorder (ortholog); Binge Drinking (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alcohol dehydrogenase 4; all-trans-retinol dehydrogenase [NAD(+)] ADH4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8121,225,656 - 121,261,746 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18121,225,485 - 121,259,262 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X98,582,002 - 98,583,002 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28130,409,996 - 130,434,606 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IEA)
nucleoplasm  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADH4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8121,225,656 - 121,261,746 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18121,225,485 - 121,259,262 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X98,582,002 - 98,583,002 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28130,409,996 - 130,434,606 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADH4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38499,123,658 - 99,144,297 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl499,123,657 - 99,157,792 (-)EnsemblGRCh38hg38GRCh38
GRCh374100,044,809 - 100,065,448 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364100,263,855 - 100,284,472 (-)NCBINCBI36Build 36hg18NCBI36
Build 344100,401,812 - 100,423,028NCBI
Celera497,342,359 - 97,362,981 (-)NCBICelera
Cytogenetic Map4q23NCBI
HuRef495,782,906 - 95,803,527 (-)NCBIHuRef
CHM1_14100,021,522 - 100,042,141 (-)NCBICHM1_1
T2T-CHM13v2.04102,438,693 - 102,459,340 (-)NCBIT2T-CHM13v2.0
Adh4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393138,121,217 - 138,138,444 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3138,121,227 - 138,136,653 (+)EnsemblGRCm39 Ensembl
GRCm383138,415,456 - 138,432,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3138,415,466 - 138,430,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv373138,078,461 - 138,093,856 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363138,352,896 - 138,368,279 (+)NCBIMGSCv36mm8
Celera3144,836,181 - 144,853,583 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map364.24NCBI
Adh4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82229,622,092 - 229,640,120 (+)NCBIGRCr8
mRatBN7.22226,948,717 - 226,966,747 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2226,947,466 - 226,987,591 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2234,697,253 - 234,715,474 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02232,596,984 - 232,615,201 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02227,461,666 - 227,479,885 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02243,702,035 - 243,720,063 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,700,784 - 243,740,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02262,237,059 - 262,254,499 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42235,952,313 - 235,970,671 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12235,939,028 - 235,957,343 (+)NCBI
Celera2219,105,553 - 219,122,791 (+)NCBICelera
Cytogenetic Map2q44NCBI
ADH4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2397,188,649 - 97,209,293 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1497,464,601 - 97,485,231 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0491,522,444 - 91,543,086 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14102,186,670 - 102,206,923 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4102,183,956 - 102,206,923 (-)Ensemblpanpan1.1panPan2
ADH4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13221,282,526 - 21,299,387 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3221,282,890 - 21,299,328 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3220,631,099 - 20,647,963 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03221,468,468 - 21,485,373 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3221,468,474 - 21,485,323 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13221,433,849 - 21,450,220 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03221,260,783 - 21,277,661 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03218,617,963 - 18,634,846 (+)NCBIUU_Cfam_GSD_1.0
ADH4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1747,226,787 - 47,248,518 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl747,226,191 - 47,248,234 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603725,658,415 - 25,678,570 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in ADH4
6 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 2 22 3 4 10 8 22 3 6 1

Sequence


Ensembl Acc Id: ENSSSCT00000010057   ⟹   ENSSSCP00000009794
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8121,225,656 - 121,251,793 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000087051   ⟹   ENSSSCP00000072135
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8121,225,657 - 121,261,746 (+)Ensembl
RefSeq Acc Id: NM_001315670   ⟹   NP_001302599
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X98,582,002 - 98,583,002 (-)NCBI
Sscrofa11.18121,225,485 - 121,259,262 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001302599 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AKV89664 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000009794
  ENSSSCP00000009794.3
  ENSSSCP00000072135.1
  ENSSSCP00015040688.1
  ENSSSCP00035011016.1
  ENSSSCP00055017499.1
  ENSSSCP00060007733.1
  ENSSSCP00065001089.1
RefSeq Acc Id: NP_001302599   ⟸   NM_001315670
- UniProtKB: A0A0K1TQM8 (UniProtKB/TrEMBL),   A0A8D0PZV4 (UniProtKB/TrEMBL),   A0A8D1QD04 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000009794   ⟸   ENSSSCT00000010057
Ensembl Acc Id: ENSSSCP00000072135   ⟸   ENSSSCT00000087051
Protein Domains
Enoyl reductase (ER)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000009184 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015073275 UniProtKB/TrEMBL
  ENSSSCG00035021909 UniProtKB/TrEMBL
  ENSSSCG00055011229 UniProtKB/TrEMBL
  ENSSSCG00060014419 UniProtKB/TrEMBL
  ENSSSCG00065002442 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000010057 ENTREZGENE
  ENSSSCT00000010057.5 UniProtKB/TrEMBL
  ENSSSCT00000087051.2 UniProtKB/TrEMBL
  ENSSSCT00015098674.1 UniProtKB/TrEMBL
  ENSSSCT00035028585.1 UniProtKB/TrEMBL
  ENSSSCT00055022098.1 UniProtKB/TrEMBL
  ENSSSCT00060019099.1 UniProtKB/TrEMBL
  ENSSSCT00065003152.1 UniProtKB/TrEMBL
Gene3D-CATH Medium-chain alcohol dehydrogenases, catalytic domain UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro ADH_C UniProtKB/TrEMBL
  ADH_N UniProtKB/TrEMBL
  ADH_Zn_CS UniProtKB/TrEMBL
  GroES-like_sf UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  PKS_ER UniProtKB/TrEMBL
KEGG Report ssc:100513366 UniProtKB/TrEMBL
NCBI Gene ADH4 ENTREZGENE
PANTHER ALCOHOL DEHYDROGENASE UniProtKB/TrEMBL
  PTHR43880:SF14 UniProtKB/TrEMBL
Pfam ADH_N UniProtKB/TrEMBL
  ADH_zinc_N UniProtKB/TrEMBL
PROSITE ADH_ZINC UniProtKB/TrEMBL
SMART PKS_ER UniProtKB/TrEMBL
Superfamily-SCOP SSF50129 UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
UniProt A0A0K1TQM8 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2R726_PIG UniProtKB/TrEMBL
  A0A8D0PZV4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1QD04 ENTREZGENE, UniProtKB/TrEMBL
  F1S0Y8_PIG UniProtKB/TrEMBL