AKR1C3 (aldo-keto reductase family 1 member C3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: AKR1C3 (aldo-keto reductase family 1 member C3) Sus scrofa
Analyze
Symbol: AKR1C3 (Ensembl: AKR1C2)
Name: aldo-keto reductase family 1 member C3 (Ensembl:aldo-keto reductase family 1, member C1)
RGD ID: 13857599
Description: ENCODES a protein that exhibits 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity (ortholog); aldo-keto reductase (NADPH) activity (ortholog); aldose reductase (NADPH) activity (ortholog); INVOLVED IN cellular response to follicle-stimulating hormone stimulus (ortholog); cellular response to forskolin (ortholog); cellular response to gonadotropin-releasing hormone (ortholog); PARTICIPATES IN isoprenoid metabolic pathway; prostaglandin biosynthetic pathway; ASSOCIATED WITH myeloid neoplasm (ortholog); polycystic ovary syndrome (ortholog); pre-eclampsia (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AKR1C1; aldo-keto reductase family 1 member C1; aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1, 20-alpha (3-alpha)-hydroxysteroid dehydrogenase); putative aldo-keto reductase family 1 member C3
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1065,576,464 - 65,678,248 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11065,650,223 - 65,679,878 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21071,902,088 - 71,931,228 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:19320734   PMID:22014308   PMID:24303814   PMID:24875897   PMID:25583233   PMID:30032202  


Genomics

Variants

.
Variants in AKR1C3
864 total Variants

Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001044618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005668230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005668231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005668232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005668236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013980354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021064078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021064079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021064080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB527065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AEMK02000074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK233202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK393235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK393546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK400494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU972427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ474067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ494490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01001462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: NM_001044618   ⟹   NP_001038083
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11065,650,373 - 65,678,294 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005668230   ⟹   XP_005668287
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11065,650,223 - 65,679,878 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005668231   ⟹   XP_005668288
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11065,650,251 - 65,679,878 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005668232   ⟹   XP_005668289
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11065,650,251 - 65,679,878 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005668236   ⟹   XP_005668293
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11065,655,607 - 65,679,878 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013980354   ⟹   XP_013835808
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11065,655,623 - 65,679,878 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021064078   ⟹   XP_020919737
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11065,650,225 - 65,674,673 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021064079   ⟹   XP_020919738
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11065,650,225 - 65,679,878 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021064080   ⟹   XP_020919739
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11065,650,225 - 65,679,878 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005668287   ⟸   XM_005668230
- Peptide Label: isoform X1
- UniProtKB: A0A480SLU2 (UniProtKB/TrEMBL),   A0A8D1ZRQ7 (UniProtKB/TrEMBL),   A0A8D0Z8G0 (UniProtKB/TrEMBL),   D0G0C4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020919738   ⟸   XM_021064079
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020919739   ⟸   XM_021064080
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_020919737   ⟸   XM_021064078
- Peptide Label: isoform X2
- UniProtKB: A0A8D1IC59 (UniProtKB/TrEMBL),   F1RYU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005668289   ⟸   XM_005668232
- Peptide Label: isoform X1
- UniProtKB: A0A480SLU2 (UniProtKB/TrEMBL),   A0A8D1ZRQ7 (UniProtKB/TrEMBL),   A0A8D0Z8G0 (UniProtKB/TrEMBL),   D0G0C4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005668288   ⟸   XM_005668231
- Peptide Label: isoform X1
- UniProtKB: A0A480SLU2 (UniProtKB/TrEMBL),   A0A8D1ZRQ7 (UniProtKB/TrEMBL),   A0A8D0Z8G0 (UniProtKB/TrEMBL),   D0G0C4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001038083   ⟸   NM_001044618
- UniProtKB: Q1KLB2 (UniProtKB/TrEMBL),   A0A4X1T4T7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005668293   ⟸   XM_005668236
- Peptide Label: isoform X1
- UniProtKB: A0A480SLU2 (UniProtKB/TrEMBL),   A0A8D1ZRQ7 (UniProtKB/TrEMBL),   A0A8D0Z8G0 (UniProtKB/TrEMBL),   D0G0C4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013835808   ⟸   XM_013980354
- Peptide Label: isoform X1
- UniProtKB: A0A480SLU2 (UniProtKB/TrEMBL),   A0A8D1ZRQ7 (UniProtKB/TrEMBL),   A0A8D0Z8G0 (UniProtKB/TrEMBL),   D0G0C4 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
NADP-dependent oxidoreductase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000011147 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00000062058 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025025024 UniProtKB/TrEMBL
  ENSSSCG00035023455 UniProtKB/TrEMBL
  ENSSSCG00045027247 UniProtKB/TrEMBL
  ENSSSCG00055000821 UniProtKB/TrEMBL
  ENSSSCG00065064769 UniProtKB/TrEMBL
  ENSSSCG00070006207 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000012199.5 UniProtKB/TrEMBL
  ENSSSCT00000012200.5 UniProtKB/TrEMBL
  ENSSSCT00000032108 ENTREZGENE
  ENSSSCT00000032108.4 UniProtKB/TrEMBL
  ENSSSCT00000042007.3 UniProtKB/TrEMBL
  ENSSSCT00000057350 ENTREZGENE
  ENSSSCT00000057350.3 UniProtKB/TrEMBL
  ENSSSCT00000068825.2 UniProtKB/TrEMBL
  ENSSSCT00000100057.1 UniProtKB/TrEMBL
  ENSSSCT00000102995.1 UniProtKB/TrEMBL
  ENSSSCT00025033923.1 UniProtKB/TrEMBL
  ENSSSCT00025034398.1 UniProtKB/TrEMBL
  ENSSSCT00025034657.1 UniProtKB/TrEMBL
  ENSSSCT00025034806.1 UniProtKB/TrEMBL
  ENSSSCT00035030758.1 UniProtKB/TrEMBL
  ENSSSCT00035030764.1 UniProtKB/TrEMBL
  ENSSSCT00035030775.1 UniProtKB/TrEMBL
  ENSSSCT00035030776.1 UniProtKB/TrEMBL
  ENSSSCT00045046722.1 UniProtKB/TrEMBL
  ENSSSCT00045047268.1 UniProtKB/TrEMBL
  ENSSSCT00055001724.1 UniProtKB/TrEMBL
  ENSSSCT00055001789.1 UniProtKB/TrEMBL
  ENSSSCT00055001825.1 UniProtKB/TrEMBL
  ENSSSCT00065089448.1 UniProtKB/TrEMBL
  ENSSSCT00065089459.1 UniProtKB/TrEMBL
  ENSSSCT00065089480.1 UniProtKB/TrEMBL
  ENSSSCT00065089490.1 UniProtKB/TrEMBL
  ENSSSCT00065089502.1 UniProtKB/TrEMBL
  ENSSSCT00065089507.1 UniProtKB/TrEMBL
  ENSSSCT00065089527.1 UniProtKB/TrEMBL
  ENSSSCT00070011995.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/TrEMBL
InterPro AKR1C UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/TrEMBL
  Aldo/keto_reductase UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:733694 UniProtKB/TrEMBL
NCBI Gene AKR1C3 ENTREZGENE
PANTHER ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 UniProtKB/TrEMBL
  ALDO-KETO REDUCTASE FAMILY 1 MEMBER C4 UniProtKB/TrEMBL
  ALDO/KETO REDUCTASE UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/TrEMBL
PIRSF AKR UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_2 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF51430 UniProtKB/TrEMBL
UniProt A0A287AK29_PIG UniProtKB/TrEMBL
  A0A480SLU2 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1T4T7 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2RFR3_PIG UniProtKB/TrEMBL
  A0A5K1UL95_PIG UniProtKB/TrEMBL
  A0A8D0R9Z9_PIG UniProtKB/TrEMBL
  A0A8D0RH33_PIG UniProtKB/TrEMBL
  A0A8D0Z8G0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1IC59 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1ZRQ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FBL5_PIG UniProtKB/TrEMBL
  A0A8W4FBQ0_PIG UniProtKB/TrEMBL
  D0G0C4 ENTREZGENE, UniProtKB/TrEMBL
  F1RYU4 ENTREZGENE, UniProtKB/TrEMBL
  F1RYV5_PIG UniProtKB/TrEMBL
  Q1HE48_PIG UniProtKB/TrEMBL
  Q1KLB2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1RYT8 UniProtKB/TrEMBL
  F1RYV6 UniProtKB/TrEMBL