Dock8<sup>m1Ztm</sup> (dedicator of cytokinesis 8;mutant 1, Ztm)

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Gene: Dock8^m1Ztm (dedicator of cytokinesis 8;mutant 1, Ztm) Rattus norvegicus

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Symbol:	Dock8^m1Ztm
Name:	dedicator of cytokinesis 8;mutant 1, Ztm
RGD ID:	13830868
Description:	A spontaneous mutation from C to G in Dock8 in exon 44 at position 228, 622, 763 (RGSC Genome Assembly v3.4) on RNO1 was identified. This mutation caused the change of glutamine to glutamate (Q1864E). The mutation is located in β4 of the DOCK homology region (DHR)-2 involved in CDC42 binding. ASSOCIATED WITH type 1 diabetes mellitus
Type:	allele of Dock8
Is Marker For:	Strains: LEW.1AR1-iddm/Ztm
Latest Assembly:	mRatBN7.2 - mRatBN7.2 Assembly
Position:	No map positions available.

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

type 1 diabetes mellitus (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes.	Arndt T, etal., Diabetologia. 2015 Dec;58(12):2800-9. doi: 10.1007/s00125-015-3757-7. Epub 2015 Sep 12.

Genomics

Related Rat Strains

The following Strains have been annotated to Dock8^m1Ztm

LEW.1AR1-iddm/Ztm

Expression

Sequence

Nucleotide Sequences

Additional Information

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InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
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