Mc4r<sup>m1Hubr</sup> (melanocortin 4 receptor; ENU induced mutation 1, Hubr) - Rat Genome Database

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Gene: Mc4rm1Hubr (melanocortin 4 receptor; ENU induced mutation 1, Hubr) Rattus norvegicus
Symbol: Mc4rm1Hubr
Name: melanocortin 4 receptor; ENU induced mutation 1, Hubr
RGD ID: 13825200
Description: The Mc4r mutation was generated by target-selected ENU-driven mutagenesis and high-throughput resequencing of genomic sequences in Crl:Wistar background. The mutation was identified as revealed an ENU-induced premature stop codon in helix 8 (K314X) of Mc4r.
ASSOCIATED WITH decreased heart rate; decreased locomotor activity; decreased mean systemic arterial blood pressure; ASSOCIATED WITH Insulin Resistance; obesity
Type: allele  of Mc4r  
Previously known as: Mc4r^[m1Hubr]
Is Marker For: Strains:   WI-Mc4rm1Hubr  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References - curated
# Reference Title Reference Citation
1. Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat. Mul JD, etal., Obesity (Silver Spring). 2012 Mar;20(3):612-21. doi: 10.1038/oby.2011.81. Epub 2011 Apr 28.
2. Vascular effects of deletion of melanocortin-4 receptors in rats. Stepp DW, etal., Physiol Rep. 2013 Nov;1(6):e00146. doi: 10.1002/phy2.146. Epub 2013 Nov 13.
3. Systematic generation of in vivo G protein-coupled receptor mutants in the rat. van Boxtel R, etal., Pharmacogenomics J. 2011 Oct;11(5):326-36. doi: 10.1038/tpj.2010.44. Epub 2010 Jun 8.


Related Rat Strains
The following Strains have been annotated to Mc4rm1Hubr



Nucleotide Sequences

Additional Information