F8<sup>em1Mcwi</sup> (coagulation factor VIII, procoagulant component; CRISPR/Cas9 induced mutant1, Mcwi) - Rat Genome Database

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Gene: F8em1Mcwi (coagulation factor VIII, procoagulant component; CRISPR/Cas9 induced mutant1, Mcwi) Rattus norvegicus
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Symbol: F8em1Mcwi
Name: coagulation factor VIII, procoagulant component; CRISPR/Cas9 induced mutant1, Mcwi
RGD ID: 13800747
Description: CRISPR/Cas9 system was used to delete the entire F8 gene in the SS/JrHsdMcwi embryos.
ASSOCIATED WITH abnormal hemostasis; hemarthrosis; increased bleeding time; ASSOCIATED WITH factor VIII deficiency; hemarthrosis
Type: allele  of F8  
Is Marker For: Strains:   SS-F8em1Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. The severe spontaneous bleeding phenotype in a novel hemophilia A rat model is rescued by platelet FVIII expression. Shi Q, etal., Blood Adv. 2020 Jan 14;4(1):55-65. doi: 10.1182/bloodadvances.2019000944.

Genomics


Related Rat Strains
The following Strains have been annotated to F8em1Mcwi


Expression


Sequence

Nucleotide Sequences


Additional Information