Hsd11b2<sup>em1Jmul</sup> (hydroxysteroid 11-beta dehydrogenase 2; ZFN induced mutant1, Jmul) - Rat Genome Database

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Gene: Hsd11b2em1Jmul (hydroxysteroid 11-beta dehydrogenase 2; ZFN induced mutant1, Jmul) Rattus norvegicus
Symbol: Hsd11b2em1Jmul
Name: hydroxysteroid 11-beta dehydrogenase 2; ZFN induced mutant1, Jmul
RGD ID: 13800560
Description: The ZFN system targeting exon 2 of Hsd11b2 gene was injected into the F344/IcoCrl embryos to induce a 123-bp deletion removing the 3' end of exon 2 and the first 16-bp of intron B and create a premature stop coden TAG.
ASSOCIATED WITH abnormal adrenal gland zona glomerulosa morphology; abnormal adrenal gland zona reticularis morphology; abnormal adrenal medulla morphology; ASSOCIATED WITH hypertension
Type: allele  of Hsd11b2  
Previously known as: Hsd11b2^[em1Jmul]
Is Marker For: Strains:   F344-Hsd11b2em1Jmul-/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References - curated
# Reference Title Reference Citation
1. Mineralocorticoid Excess or Glucocorticoid Insufficiency: Renal and Metabolic Phenotypes in a Rat Hsd11b2 Knockout Model. Mullins LJ, etal., Hypertension. 2015 Sep;66(3):667-73. doi: 10.1161/HYPERTENSIONAHA.115.05262. Epub 2015 Jun 15.


Related Rat Strains
The following Strains have been annotated to Hsd11b2em1Jmul



Nucleotide Sequences

Additional Information