Fh<sup>em1</sup> (fumarate hydratase; TALEN induced mutant 1)

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Gene: Fh^em1 (fumarate hydratase; TALEN induced mutant 1) Rattus norvegicus

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Symbol:	Fh^em1
Name:	fumarate hydratase; TALEN induced mutant 1
RGD ID:	13792797
Description:	A pair of TALENs targeting exon 1 of the Fh gene was injected into SD embryos to create Fh knock out mutants. The resulting mutation was an 11-bp deletion (acacctttggt) on exon 1 that caused premature stop of FH protein. ASSOCIATED WITH abnormal kidney morphology; abnormal lymphocyte morphology; decreased blood uric acid level
Type:	allele of Fh
Is Marker For:	Strains: SD-Fh^em1+/-
Latest Assembly:	mRatBN7.2 - mRatBN7.2 Assembly
Position:	No map positions available.

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Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal kidney morphology (IMP)

abnormal lymphocyte morphology (IMP)

decreased blood uric acid level (IMP)

decreased eosinophil cell number (IMP)

decreased hematocrit (IMP)

decreased leukocyte cell number (IMP)

decreased litter size (IMP)

decreased lymphocyte cell number (IMP)

decreased monocyte cell number (IMP)

embryonic lethality (IMP)

increased blood urea nitrogen level (IMP)

increased body weight (IMP)

increased circulating creatinine level (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Generation of TALEN-mediated FH knockout rat model.	Yu D, etal., Oncotarget. 2016 Sep 20;7(38):61656-61669. doi: 10.18632/oncotarget.11429.

Genomics

Related Rat Strains

The following Strains have been annotated to Fh^em1

SD-Fh^em1+/-

Expression

Sequence

Nucleotide Sequences

Additional Information

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-09-28	Fh^em1	fumarate hydratase; TALEN induced mutant 1	Fh^em1		Name changed	629549	APPROVED

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Mammalian Phenotype