Cd59<sup>em1Ask</sup> (CD59 molecule; CRISPR/Cas9 induced mutant1, Ask) - Rat Genome Database

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Gene: Cd59em1Ask (CD59 molecule; CRISPR/Cas9 induced mutant1, Ask) Rattus norvegicus
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Symbol: Cd59em1Ask
Name: CD59 molecule; CRISPR/Cas9 induced mutant1, Ask
RGD ID: 13792720
Description: The CRISPR/Cas9 genome editing system was used to generate Cd59 mutation in the Sprague Dawley embryos. The CRISPR/Cas9 targeting exon 3 of the rat Cd59 created a 11 bp-deletion (TGCAAAACAAA) in exon 3. No protein expression was detected in the blood smear of homozygous mutants.
ASSOCIATED WITH decreased erythrocyte cell number; increased red blood cell distribution width; increased susceptibility to type III hypersensitivity reaction; ASSOCIATED WITH neuromyelitis optica
Type: allele  of Cd59  
Is Marker For: Strains:   SD-Cd59em1Ask-/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


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Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G. Yao X and Verkman AS, Acta Neuropathol Commun. 2017 Feb 17;5(1):15. doi: 10.1186/s40478-017-0417-9.

Genomics


Related Rat Strains
The following Strains have been annotated to Cd59em1Ask


Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-09-24 Cd59em1Ask  CD59 molecule; CRISPR/Cas9 induced mutant1, Ask  Cd59em1Ask  CD59 molecule; CRISPR/Cas9 induced mutant1, Ask  Symbol changed 629549 APPROVED
2018-09-24 Cd59em1Ask  CD59 molecule; CRISPR/Cas9 induced mutant1, Ask  Cd59em1Ask-/-  CD59 molecule; CRISPR/Cas9 induced mutant1, Ask  Symbol changed 629549 APPROVED