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Gene: Oprl1^m1Hubr (opioid related nociceptin receptor 1; ENU induced mutant1, Hubr) Rattus norvegicus

Symbol:	Oprl1^m1Hubr
Name:	opioid related nociceptin receptor 1; ENU induced mutant1, Hubr
RGD ID:	13792571
Description:	The original mutation was created by target-selected ENU-induced mutagenesis in a Brown Norway background.Then they were subsequently backcrossed on a Wistar (Crl:WI) background. A C to G transversion at position 3657 in the oprl1 gene (ENSRNOG00000016768), resulting into a premature stop codon (TAC>TAG) in the third exon. ASSOCIATED WITH decreased chemical nociceptive threshold; decreased mechanical nociceptive threshold; enhanced conditioned place preference behavior
Type:	allele of Oprl1
Previously known as:	Oprl1^[m1Hubr]
Is Marker For:	Strains: WI-Oprl1^m1Hubr+/- WI-Oprl1^m1Hubr-/-
Latest Assembly:	GRCr8 - GRCr8 Assembly
Position:	No map positions available.

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated

#	Reference Title	Reference Citation
1.	Visceral hypersensitivity in female but not in male serotonin transporter knockout rats.	Galligan JJ, etal., Neurogastroenterol Motil. 2013 Jun;25(6):e373-81. doi: 10.1111/nmo.12133. Epub 2013 Apr 17.
2.	Complete knockout of the nociceptin/orphanin FQ receptor in the rat does not induce compensatory changes in mu, delta and kappa opioid receptors.	Homberg JR, etal., Neuroscience. 2009 Sep 29;163(1):308-15. doi: 10.1016/j.neuroscience.2009.06.021. Epub 2009 Jun 12.
3.	Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats.	Micheli L, etal., Eur J Pharmacol. 2015 May 5;754:73-81. doi: 10.1016/j.ejphar.2015.02.020. Epub 2015 Feb 19.
4.	Nociceptin/orphanin FQ receptor knockout rats: in vitro and in vivo studies.	Rizzi A, etal., Neuropharmacology. 2011 Mar;60(4):572-9. doi: 10.1016/j.neuropharm.2010.12.010. Epub 2010 Dec 22.
5.	Pharmacological blockade or genetic knockout of the NOP receptor potentiates the rewarding effect of morphine in rats.	Rutten K, etal., Drug Alcohol Depend. 2011 Apr 1;114(2-3):253-6. doi: 10.1016/j.drugalcdep.2010.10.004. Epub 2010 Nov 20.

Genomics

Related Rat Strains

The following Strains have been annotated to Oprl1^m1Hubr

WI-Oprl1^m1Hubr+/- WI-Oprl1^m1Hubr-/-

Expression

RNA-SEQ Expression

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Sequence

Nucleotide Sequences

Additional Information

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-05-17	Oprl1^m1Hubr	opioid related nociceptin receptor 1; ENU induced mutant1, Hubr	Oprl1^m1Hubr	opioid related nociceptin receptor 1; ZFN induced mutant1, Hubr	Name changed	629549	APPROVED
2019-02-18	Oprl1^m1Hubr	opioid related nociceptin receptor 1; ZFN induced mutant1, Hubr	Oprl1^m1Hubr		Name changed	629549	APPROVED

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