Rnaset2<sup>em1Sage</sup> (ribonuclease T2; CRISPR/Cas9 induced mutant 1, Sage) - Rat Genome Database

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Gene: Rnaset2em1Sage (ribonuclease T2; CRISPR/Cas9 induced mutant 1, Sage) Rattus norvegicus
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Symbol: Rnaset2em1Sage
Name: ribonuclease T2; CRISPR/Cas9 induced mutant 1, Sage
RGD ID: 13781891
Description: Two pairs of CRISPR guide RNAs were designed to cleave together to delete all 9 exons of RNaseT2. The CRISPR guide RNA and Cas9 mRNA mixtures were microinjected into the pronuclei of fertilized embryos of Sprague-Dawley rats and transferred to pseudopregnant female rats.
ASSOCIATED WITH brain inflammation; decreased exploration in new environment
Type: allele  of Rnaset2  
Previously known as: Rnaset2^[em1Sage]
Is Marker For: Strains:   SD-Rnaset2em1Sage  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory. Sinkevicius KW, etal., Dis Model Mech. 2018 Jun 27;11(6). pii: dmm.032631. doi: 10.1242/dmm.032631.

Genomics


Related Rat Strains
The following Strains have been annotated to Rnaset2em1Sage
SD-Rnaset2em1Sage    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information