Rnase11 (ribonuclease A family member 11) - Rat Genome Database

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Gene: Rnase11 (ribonuclease A family member 11) Rattus norvegicus
Analyze
Symbol: Rnase11
Name: ribonuclease A family member 11
RGD ID: 1359723
Description: Predicted to enable nucleic acid binding activity. Predicted to be involved in defense response to Gram-positive bacterium. Orthologous to human RNASE11 (ribonuclease A family member 11 (inactive)); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: probable ribonuclease 11; Raj1; ribonuclease 11; ribonuclease A j1; ribonuclease, RNase A family, 11 (non-active)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,741,732 - 26,743,718 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1526,739,801 - 26,746,249 (-)EnsemblGRCr8
mRatBN7.21524,268,206 - 24,270,192 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,268,207 - 24,270,192 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1527,039,374 - 27,041,360 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01527,998,790 - 28,000,776 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,247,929 - 26,249,915 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01527,972,201 - 27,977,885 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,973,491 - 27,975,471 (-)Ensemblrn6Rnor6.0
Rnor_5.01531,806,254 - 31,808,366 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41527,027,916 - 27,029,902 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1524,588,085 - 24,590,071 (-)NCBICelera
RGSC_v3.11527,044,447 - 27,045,018 (-)NCBI
Cytogenetic Map15p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. Cho S, etal., Genomics. 2005 Feb;85(2):208-20.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:24337645  


Genomics

Comparative Map Data
Rnase11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,741,732 - 26,743,718 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1526,739,801 - 26,746,249 (-)EnsemblGRCr8
mRatBN7.21524,268,206 - 24,270,192 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,268,207 - 24,270,192 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1527,039,374 - 27,041,360 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01527,998,790 - 28,000,776 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,247,929 - 26,249,915 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01527,972,201 - 27,977,885 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,973,491 - 27,975,471 (-)Ensemblrn6Rnor6.0
Rnor_5.01531,806,254 - 31,808,366 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41527,027,916 - 27,029,902 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1524,588,085 - 24,590,071 (-)NCBICelera
RGSC_v3.11527,044,447 - 27,045,018 (-)NCBI
Cytogenetic Map15p14NCBI
RNASE11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,582,892 - 20,590,257 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1420,582,892 - 20,609,884 (-)Ensemblhg38GRCh38
GRCh371421,051,051 - 21,058,416 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,120,891 - 20,128,257 (-)NCBIBuild 36Build 36hg18NCBI36
Celera14911,926 - 919,293 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,172,009 - 1,179,372 (-)NCBIHuRef
CHM1_11421,053,073 - 21,060,438 (-)NCBICHM1_1
T2T-CHM13v2.01414,780,017 - 14,787,383 (-)NCBIT2T-CHM13v2.0
Rnase11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,286,150 - 51,293,159 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,286,908 - 51,287,620 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381451,048,693 - 51,055,702 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,049,451 - 51,050,163 (-)Ensemblmm10GRCm38
MGSCv371451,669,192 - 51,669,770 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361449,971,468 - 49,972,046 (-)NCBIMGSCv36mm8
Celera1447,327,070 - 47,327,648 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.36NCBI
Rnase11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555501,386,452 - 1,387,057 (-)NCBIChiLan1.0ChiLan1.0
RNASE11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21522,082,729 - 22,109,954 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11421,299,216 - 21,326,441 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,448,613 - 1,455,466 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11419,505,838 - 19,512,691 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,506,019 - 19,506,618 (-)EnsemblpanPan2panpan1.1
Rnase11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864077,834,874 - 77,835,696 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004937190123,663 - 124,262 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004937190123,663 - 124,262 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNASE11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1778,344,002 - 78,345,782 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2783,371,007 - 83,372,326 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RNASE11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,105,509 - 21,131,991 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2921,106,512 - 21,107,111 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605925,319,217 - 25,324,222 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnase11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248254,592,962 - 4,593,551 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Rnase11
18 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:401
Count of miRNA genes:221
Interacting mature miRNAs:254
Transcripts:ENSRNOT00000060614
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152024860037896129Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 1 3 70 67 65 46 19 46 5 119 37 3 52 28 36 19 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000060614   ⟹   ENSRNOP00000057347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1526,741,733 - 26,743,944 (-)Ensembl
mRatBN7.2 Ensembl1524,268,207 - 24,270,192 (-)Ensembl
Rnor_6.0 Ensembl1527,973,491 - 27,975,471 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000165605   ⟹   ENSRNOP00000109567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1526,739,801 - 26,746,249 (-)Ensembl
RefSeq Acc Id: NM_001012476   ⟹   NP_001012494
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,741,732 - 26,743,718 (-)NCBI
mRatBN7.21524,268,206 - 24,270,192 (-)NCBI
Rnor_6.01527,973,485 - 27,975,471 (-)NCBI
Rnor_5.01531,806,254 - 31,808,366 (-)NCBI
RGSC_v3.41527,027,916 - 27,029,902 (-)RGD
Celera1524,588,085 - 24,590,071 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001012494 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI28715 (Get FASTA)   NCBI Sequence Viewer  
  AAV87200 (Get FASTA)   NCBI Sequence Viewer  
  CDG32042 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000057347.2
  ENSRNOP00000109567
RefSeq Acc Id: NP_001012494   ⟸   NM_001012476
- Peptide Label: precursor
- UniProtKB: Q5GAL9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000057347   ⟸   ENSRNOT00000060614
Ensembl Acc Id: ENSRNOP00000109567   ⟸   ENSRNOT00000165605

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5GAL9-F1-model_v2 AlphaFold Q5GAL9 1-190 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359723 AgrOrtholog
BioCyc Gene G2FUF-14041 BioCyc
Ensembl Genes ENSRNOG00000039543 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060614.4 UniProtKB/TrEMBL
  ENSRNOT00000165605 ENTREZGENE
IMAGE_CLONE IMAGE:7134188 IMAGE-MGC_LOAD
InterPro RNaseA UniProtKB/TrEMBL
KEGG Report rno:497651 UniProtKB/TrEMBL
MGC_CLONE MGC:156529 IMAGE-MGC_LOAD
NCBI Gene 497651 ENTREZGENE
PANTHER RIBONUCLEASE UniProtKB/TrEMBL
  RIBONUCLEASE 11-RELATED UniProtKB/TrEMBL
PhenoGen Rnase11 PhenoGen
RatGTEx ENSRNOG00000039543 RatGTEx
UniProt Q5GAL9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Rnase11  ribonuclease A family member 11  Rnase11  ribonuclease, RNase A family, 11 (non-active)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Rnase11  ribonuclease, RNase A family, 11 (non-active)  Rnase11  ribonuclease 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Rnase11  ribonuclease 11      Symbol and Name updated 1559027 APPROVED
2005-07-29 Rnase11  ribonuclease 11      Symbol and Name status set to provisional 70820 PROVISIONAL