Rnd3 (Rho family GTPase 3) - Rat Genome Database

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Gene: Rnd3 (Rho family GTPase 3) Rattus norvegicus
Analyze
Symbol: Rnd3
Name: Rho family GTPase 3
RGD ID: 1359690
Description: Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin filament organization; regulation of actin cytoskeleton organization; and signal transduction. Predicted to be active in cytosol and plasma membrane. Orthologous to human RND3 (Rho family GTPase 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Arhe; ras homolog gene family, member E; rho-related GTP-binding protein RhoE; RHOE
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8355,981,142 - 55,998,494 (-)NCBIGRCr8
mRatBN7.2335,571,929 - 35,589,283 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl335,571,143 - 35,589,327 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx338,969,914 - 38,987,277 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0347,554,663 - 47,572,026 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0345,332,304 - 45,350,239 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0336,643,374 - 36,660,727 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl336,642,587 - 36,660,758 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0341,757,186 - 41,774,539 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4332,101,433 - 32,118,785 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1331,997,804 - 32,015,157 (-)NCBI
Celera333,730,327 - 33,747,679 (-)NCBICelera
Cytogenetic Map3q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
amphetamine  (EXP)
amphotericin B  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corosolic acid  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cyproconazole  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
glyphosate  (EXP)
imidacloprid  (EXP)
isotretinoin  (ISO)
ketamine  (EXP)
lead(0)  (ISO)
lithium chloride  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metformin  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
nickel dichloride  (EXP)
nicotine  (ISO)
oxaliplatin  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
progesterone  (ISO)
quinomethionate  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
SL-327  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloro-1,4-benzoquinone  (ISO)
tetrachloromethane  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
troglitazone  (EXP)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)
membrane  (IEA)
plasma membrane  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. RhoE binds to ROCK I and inhibits downstream signaling. Riento K, etal., Mol Cell Biol. 2003 Jun;23(12):4219-29.
6. RhoE inhibits cell cycle progression and Ras-induced transformation. Villalonga P, etal., Mol Cell Biol 2004 Sep;24(18):7829-40.
Additional References at PubMed
PMID:12477932   PMID:14732713   PMID:16311049   PMID:21423176   PMID:23376485   PMID:23762244   PMID:32705255   PMID:38724005  


Genomics

Comparative Map Data
Rnd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8355,981,142 - 55,998,494 (-)NCBIGRCr8
mRatBN7.2335,571,929 - 35,589,283 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl335,571,143 - 35,589,327 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx338,969,914 - 38,987,277 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0347,554,663 - 47,572,026 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0345,332,304 - 45,350,239 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0336,643,374 - 36,660,727 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl336,642,587 - 36,660,758 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0341,757,186 - 41,774,539 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4332,101,433 - 32,118,785 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1331,997,804 - 32,015,157 (-)NCBI
Celera333,730,327 - 33,747,679 (-)NCBICelera
Cytogenetic Map3q12NCBI
RND3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382150,468,193 - 150,487,695 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2150,468,195 - 150,539,011 (-)EnsemblGRCh38hg38GRCh38
GRCh372151,324,707 - 151,344,209 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362151,032,955 - 151,052,426 (-)NCBINCBI36Build 36hg18NCBI36
Build 342151,150,216 - 151,169,688NCBI
Celera2144,938,960 - 144,958,449 (-)NCBICelera
Cytogenetic Map2q23.3NCBI
HuRef2143,221,253 - 143,240,784 (-)NCBIHuRef
CHM1_12151,330,489 - 151,349,997 (-)NCBICHM1_1
T2T-CHM13v2.02150,918,573 - 150,938,077 (-)NCBIT2T-CHM13v2.0
Rnd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39251,020,451 - 51,039,123 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl251,020,450 - 51,039,123 (-)EnsemblGRCm39 Ensembl
GRCm38251,130,439 - 51,149,111 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl251,130,438 - 51,149,111 (-)EnsemblGRCm38mm10GRCm38
MGSCv37250,985,959 - 51,004,631 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36250,952,448 - 50,971,120 (-)NCBIMGSCv36mm8
Celera252,814,575 - 52,833,308 (-)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map229.63NCBI
Rnd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544016,106,555 - 16,113,337 (-)NCBIChiLan1.0ChiLan1.0
RND3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21324,453,723 - 24,473,246 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B24,468,716 - 24,488,201 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B9,387,338 - 9,406,785 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B154,813,235 - 154,832,768 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B154,810,039 - 154,832,768 (-)Ensemblpanpan1.1panPan2
RND3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11951,889,693 - 51,909,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1951,891,494 - 51,909,033 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1952,002,669 - 52,022,012 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01953,352,354 - 53,372,496 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1953,352,356 - 53,373,467 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11952,048,081 - 52,066,346 (-)NCBIUMICH_Zoey_3.1
UMICH_Zoey_3.11952,034,519 - 52,038,409 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01952,130,759 - 52,149,808 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01953,545,000 - 53,564,447 (-)NCBIUU_Cfam_GSD_1.0
Rnd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303114,618,761 - 114,636,348 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646926,981,318 - 27,000,739 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646926,981,358 - 26,998,902 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RND3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl151,715,207 - 1,734,414 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1151,715,589 - 1,732,605 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215999,583 - 1,008,986 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RND3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11035,877,147 - 35,897,318 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1035,877,153 - 35,897,286 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040163,652,947 - 163,672,492 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248663,345,774 - 3,364,345 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248663,346,747 - 3,363,962 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rnd3
95 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:326
Count of miRNA genes:178
Interacting mature miRNAs:236
Transcripts:ENSRNOT00000006111
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298073Cm13Cardiac mass QTL 132.5heart mass (VT:0007028)heart wet weight (CMO:0000069)32501391138192233Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)32749462144188411Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)32749462150302886Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)32749462150302886Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)32749462150302886Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat

Markers in Region
RH143020  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2335,572,114 - 35,572,385 (+)MAPPERmRatBN7.2
Rnor_6.0336,643,560 - 36,643,830NCBIRnor6.0
Rnor_5.0341,757,372 - 41,757,642UniSTSRnor5.0
RGSC_v3.4332,101,619 - 32,101,889UniSTSRGSC3.4
Celera333,730,513 - 33,730,783UniSTS
RH 3.4 Map3426.2UniSTS
Cytogenetic Map3q12UniSTS
RH128302  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2335,571,348 - 35,571,546 (+)MAPPERmRatBN7.2
Rnor_6.0336,642,794 - 36,642,991NCBIRnor6.0
Rnor_5.0341,756,606 - 41,756,803UniSTSRnor5.0
RGSC_v3.4332,100,853 - 32,101,050UniSTSRGSC3.4
Celera333,729,747 - 33,729,944UniSTS
RH 3.4 Map3421.9UniSTS
Cytogenetic Map3q12UniSTS
RH142874  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2335,578,739 - 35,578,889 (+)MAPPERmRatBN7.2
Rnor_6.0336,650,185 - 36,650,334NCBIRnor6.0
Rnor_5.0341,763,997 - 41,764,146UniSTSRnor5.0
RGSC_v3.4332,108,244 - 32,108,393UniSTSRGSC3.4
Celera333,737,138 - 33,737,287UniSTS
Cytogenetic Map3q12UniSTS
RH139131  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2335,578,606 - 35,578,728 (+)MAPPERmRatBN7.2
Rnor_6.0336,650,052 - 36,650,173NCBIRnor6.0
Rnor_5.0341,763,864 - 41,763,985UniSTSRnor5.0
RGSC_v3.4332,108,111 - 32,108,232UniSTSRGSC3.4
Celera333,737,005 - 33,737,126UniSTS
RH 3.4 Map3429.0UniSTS
Cytogenetic Map3q12UniSTS
RH140139  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map3445.9UniSTS
Cytogenetic Map3q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 33 56 41 17 41 4 4 70 35 34 11 4
Low 10 1 2 4 7 4 7 4
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000006111   ⟹   ENSRNOP00000006111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl335,571,143 - 35,589,327 (-)Ensembl
Rnor_6.0 Ensembl336,642,587 - 36,660,758 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095476   ⟹   ENSRNOP00000079889
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl335,574,679 - 35,589,327 (-)Ensembl
RefSeq Acc Id: NM_001007641   ⟹   NP_001007642
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8355,981,142 - 55,998,494 (-)NCBI
mRatBN7.2335,571,929 - 35,589,283 (-)NCBI
Rnor_6.0336,643,374 - 36,660,727 (-)NCBI
Rnor_5.0341,757,186 - 41,774,539 (-)NCBI
RGSC_v3.4332,101,433 - 32,118,785 (-)RGD
Celera333,730,327 - 33,747,679 (-)RGD
Sequence:
RefSeq Acc Id: NP_001007642   ⟸   NM_001007641
- UniProtKB: Q6SA80 (UniProtKB/Swiss-Prot),   B4F757 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006111   ⟸   ENSRNOT00000006111
RefSeq Acc Id: ENSRNOP00000079889   ⟸   ENSRNOT00000095476

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6SA80-F1-model_v2 AlphaFold Q6SA80 1-244 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692072
Promoter ID:EPDNEW_R2597
Type:single initiation site
Name:Rnd3_1
Description:Rho family GTPase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0336,660,769 - 36,660,829EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359690 AgrOrtholog
BioCyc Gene G2FUF-49746 BioCyc
Ensembl Genes ENSRNOG00000004624 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055000580 UniProtKB/Swiss-Prot
  ENSRNOG00060018301 UniProtKB/Swiss-Prot
  ENSRNOG00065008337 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006111 ENTREZGENE
  ENSRNOT00000006111.7 UniProtKB/Swiss-Prot
  ENSRNOT00000095476.1 UniProtKB/TrEMBL
  ENSRNOT00055000994 UniProtKB/Swiss-Prot
  ENSRNOT00060031459 UniProtKB/Swiss-Prot
  ENSRNOT00065013234 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:295588 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 295588 ENTREZGENE
PANTHER PTHR24072 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO-RELATED GTP-BINDING PROTEIN RHOE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rnd3 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004624 RatGTEx
  ENSRNOG00055000580 RatGTEx
  ENSRNOG00060018301 RatGTEx
  ENSRNOG00065008337 RatGTEx
SMART RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZNJ1_RAT UniProtKB/TrEMBL
  B4F757 ENTREZGENE, UniProtKB/TrEMBL
  Q6SA80 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Rnd3  Rho family GTPase 3  Arhe  ras homolog gene family, member E  Symbol and Name updated 1299863 APPROVED
2005-07-29 Arhe  ras homolog gene family, member E      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction mouse homolog binds the amino-terminal region of the Rock1 protein in the kinase domain; does not compete with carboxy-terminal Rhoa binding 1559164