Skp1 (S-phase kinase-associated protein 1) - Rat Genome Database

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Gene: Skp1 (S-phase kinase-associated protein 1) Rattus norvegicus
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Symbol: Skp1
Name: S-phase kinase-associated protein 1
RGD ID: 1359648
Description: Predicted to enable several functions, including F-box domain binding activity; beta-catenin binding activity; and cullin family protein binding activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; maintenance of protein location in nucleus; and protein polyubiquitination. Predicted to act upstream of or within several processes, including positive regulation of epithelial cell apoptotic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Located in gap junction. Orthologous to human SKP1 (S-phase kinase associated protein 1); PARTICIPATES IN Notch signaling pathway; nuclear factor kappa B signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; Brodifacoum.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cyclin A/CDK2-associated p19; cyclin A/CDK2-associated protein p19; cyclin-A/CDK2-associated protein p19; organ of Corti protein 2; p19A; p19skp1; RNA polymerase II elongation factor-like protein OCP2; S-phase kinase-associated protein 1A; Skp1a; transcription elongation factor B (SIII), polypeptide 1-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,898,670 - 36,917,828 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1036,903,078 - 36,918,308 (+)EnsemblGRCr8
mRatBN7.21036,401,987 - 36,417,066 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1036,402,153 - 36,417,388 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1041,096,029 - 41,110,942 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01040,585,994 - 40,600,907 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01036,089,722 - 36,104,635 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01037,594,578 - 37,609,498 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,594,578 - 37,609,498 (+)Ensemblrn6Rnor6.0
Rnor_5.01037,368,051 - 37,383,130 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41037,665,417 - 37,680,338 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1035,756,586 - 35,771,498 (+)NCBICelera
RGSC_v3.11037,671,846 - 37,686,768 (+)NCBI
Cytogenetic Map10q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
calycosin  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
coumarin  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dimethylarsinous acid  (ISO)
disodium selenite  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folpet  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
graphite  (ISO)
indometacin  (ISO)
inulin  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
methidathion  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
Nutlin-3  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
sertraline  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
T-2 toxin  (EXP)
thapsigargin  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IEA,ISO)
Cul7-RING ubiquitin ligase complex  (IEA,ISO,ISS)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO,ISS)
gap junction  (IDA)
nucleus  (IBA,IEA,ISO)
PcG protein complex  (IEA,ISO)
protein-containing complex  (ISO)
SCF ubiquitin ligase complex  (IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
3. OCP2 immunoreactivity in the human fetal cochlea at weeks 11, 17, 20, and 28, and the human adult cochlea. Kammen-Jolly K, etal., Hear Res. 2002 May;167(1-2):102-9. doi: 10.1016/s0378-5955(02)00354-4.
4. ATP-dependent activation of p21WAF1/CIP1-associated Cdk2 by Cdc6. Kan Q, etal., Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4757-62. doi: 10.1073/pnas.0706392105. Epub 2008 Mar 20.
5. Expanding role of ubiquitination in NF-kappaB signaling. Liu S and Chen ZJ, Cell Res. 2011 Jan;21(1):6-21. Epub 2010 Dec 7.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. A family of mammalian F-box proteins. Winston JT, etal., Curr Biol 1999 Oct 21;9(20):1180-2.
Additional References at PubMed
PMID:10485847   PMID:11158290   PMID:11956208   PMID:12140560   PMID:12665572   PMID:12820959   PMID:14673179   PMID:15103331   PMID:15145941   PMID:15489334   PMID:15996101   PMID:16880511  
PMID:16943429   PMID:18498745   PMID:18929646   PMID:19028597   PMID:20347421   PMID:20596027   PMID:21378169   PMID:21572392   PMID:21572988   PMID:21725316   PMID:22258892   PMID:22871113  
PMID:22972877   PMID:23263282   PMID:23376485   PMID:23452856   PMID:25585578   PMID:28007894   PMID:29593216   PMID:35352799  


Genomics

Comparative Map Data
Skp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,898,670 - 36,917,828 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1036,903,078 - 36,918,308 (+)EnsemblGRCr8
mRatBN7.21036,401,987 - 36,417,066 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1036,402,153 - 36,417,388 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1041,096,029 - 41,110,942 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01040,585,994 - 40,600,907 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01036,089,722 - 36,104,635 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01037,594,578 - 37,609,498 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,594,578 - 37,609,498 (+)Ensemblrn6Rnor6.0
Rnor_5.01037,368,051 - 37,383,130 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41037,665,417 - 37,680,338 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1035,756,586 - 35,771,498 (+)NCBICelera
RGSC_v3.11037,671,846 - 37,686,768 (+)NCBI
Cytogenetic Map10q22NCBI
SKP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385134,148,935 - 134,176,950 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5134,148,935 - 134,177,029 (-)Ensemblhg38GRCh38
GRCh375133,484,626 - 133,512,641 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365133,520,468 - 133,540,583 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345133,520,467 - 133,540,583NCBI
Celera5129,615,775 - 129,636,409 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5128,677,052 - 128,697,683 (-)NCBIHuRef
CHM1_15132,924,656 - 132,945,272 (-)NCBICHM1_1
T2T-CHM13v2.05134,672,565 - 134,700,570 (-)NCBIT2T-CHM13v2.0
Skp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391152,121,349 - 52,137,685 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1152,122,822 - 52,137,685 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381152,230,522 - 52,246,858 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1152,231,995 - 52,246,858 (+)Ensemblmm10GRCm38
MGSCv371152,045,497 - 52,060,360 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361152,075,432 - 52,090,281 (+)NCBIMGSCv36mm8
Celera1156,801,165 - 56,816,028 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.86NCBI
Skp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554085,392,839 - 5,412,644 (-)Ensembl
ChiLan1.0NW_0049554085,393,851 - 5,412,644 (-)NCBIChiLan1.0ChiLan1.0
SKP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24129,455,839 - 129,478,297 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15127,595,401 - 127,617,859 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05129,560,086 - 129,580,188 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15135,713,085 - 135,732,665 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5135,713,085 - 135,729,653 (-)EnsemblpanPan2panpan1.1
SKP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11122,352,735 - 22,366,599 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1122,352,439 - 22,364,024 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1121,098,642 - 21,112,489 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01123,152,831 - 23,168,252 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1123,152,162 - 23,164,892 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11121,853,772 - 21,867,627 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01121,718,806 - 21,732,658 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01122,361,395 - 22,375,242 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Skp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213114,070,872 - 114,088,084 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366471,072,855 - 1,094,139 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366471,073,647 - 1,090,841 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SKP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2136,458,949 - 136,476,005 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12136,458,772 - 136,476,364 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SKP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12336,961,572 - 36,978,849 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2336,962,328 - 36,978,757 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603440,956,691 - 40,974,891 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Skp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473338,051,280 - 38,069,648 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Skp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1934,727,602 - 34,742,934 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Skp1
104 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:539
Count of miRNA genes:265
Interacting mature miRNAs:326
Transcripts:ENSRNOT00000007676
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
Tceb1l-rs1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01835,610,106 - 35,610,325NCBIRnor5.0
Rnor_5.01835,405,109 - 35,405,328NCBIRnor5.0
Rnor_5.01037,382,354 - 37,382,565NCBIRnor5.0
RGSC_v3.41037,679,722 - 37,679,932UniSTSRGSC3.4
RGSC_v3.41838,158,463 - 38,158,681UniSTSRGSC3.4
Celera1035,770,882 - 35,771,092UniSTS
Cytogenetic Map18q11UniSTS
Cytogenetic Map10q22UniSTS
RH137096  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21036,416,641 - 36,416,847 (+)MAPPERmRatBN7.2
Rnor_6.01037,609,233 - 37,609,438NCBIRnor6.0
Rnor_5.01037,382,706 - 37,382,911UniSTSRnor5.0
RGSC_v3.41037,680,073 - 37,680,278UniSTSRGSC3.4
Celera1035,771,233 - 35,771,438UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001007608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC130253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000007676   ⟹   ENSRNOP00000007676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1036,903,078 - 36,918,308 (+)Ensembl
mRatBN7.2 Ensembl1036,407,035 - 36,417,388 (+)Ensembl
Rnor_6.0 Ensembl1037,594,578 - 37,609,498 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085463   ⟹   ENSRNOP00000073214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1036,402,153 - 36,417,058 (+)Ensembl
Rnor_6.0 Ensembl1037,594,824 - 37,609,498 (+)Ensembl
RefSeq Acc Id: NM_001007608   ⟹   NP_001007609
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,902,908 - 36,917,828 (+)NCBI
mRatBN7.21036,401,987 - 36,416,907 (+)NCBI
Rnor_6.01037,594,578 - 37,609,498 (+)NCBI
Rnor_5.01037,368,051 - 37,383,130 (+)NCBI
RGSC_v3.41037,665,417 - 37,680,338 (+)RGD
Celera1035,756,586 - 35,771,498 (+)RGD
Sequence:
RefSeq Acc Id: XM_039085386   ⟹   XP_038941314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,903,029 - 36,917,827 (+)NCBI
mRatBN7.21036,402,173 - 36,417,066 (+)NCBI
RefSeq Acc Id: XM_063268587   ⟹   XP_063124657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,903,057 - 36,917,038 (+)NCBI
RefSeq Acc Id: XM_063268588   ⟹   XP_063124658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,899,326 - 36,917,038 (+)NCBI
RefSeq Acc Id: XM_063268589   ⟹   XP_063124659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,898,670 - 36,917,038 (+)NCBI
RefSeq Acc Id: XM_063268590   ⟹   XP_063124660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,899,272 - 36,917,827 (+)NCBI
RefSeq Acc Id: XM_063268591   ⟹   XP_063124661
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,899,287 - 36,917,827 (+)NCBI
RefSeq Acc Id: NP_001007609   ⟸   NM_001007608
- UniProtKB: Q6PEC4 (UniProtKB/Swiss-Prot),   A6HEA2 (UniProtKB/TrEMBL),   A0A8L2Q2U6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073214   ⟸   ENSRNOT00000085463
Ensembl Acc Id: ENSRNOP00000007676   ⟸   ENSRNOT00000007676
RefSeq Acc Id: XP_038941314   ⟸   XM_039085386
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K4X8 (UniProtKB/TrEMBL),   A0A8L2Q2U6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124659   ⟸   XM_063268589
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q2U6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124660   ⟸   XM_063268590
- Peptide Label: isoform X4
- UniProtKB: Q6PEC4 (UniProtKB/Swiss-Prot),   A0A8L2Q2U6 (UniProtKB/TrEMBL),   A6HEA2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124661   ⟸   XM_063268591
- Peptide Label: isoform X4
- UniProtKB: Q6PEC4 (UniProtKB/Swiss-Prot),   A0A8L2Q2U6 (UniProtKB/TrEMBL),   A6HEA2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124658   ⟸   XM_063268588
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q2U6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124657   ⟸   XM_063268587
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q2U6 (UniProtKB/TrEMBL)
Protein Domains
SKP1 component dimerisation   SKP1 component POZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6PEC4-F1-model_v2 AlphaFold Q6PEC4 1-163 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697171
Promoter ID:EPDNEW_R7693
Type:multiple initiation site
Name:Skp1_1
Description:S-phase kinase-associated protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01037,594,580 - 37,594,640EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359648 AgrOrtholog
BioCyc Gene G2FUF-25175 BioCyc
Ensembl Genes ENSRNOG00000005828 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000007676 ENTREZGENE
Gene3D-CATH Potassium Channel Kv1.1, Chain A UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6890712 IMAGE-MGC_LOAD
InterPro SKP1 UniProtKB/Swiss-Prot
  SKP1-like UniProtKB/Swiss-Prot
  SKP1-like_dim_sf UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot
  Skp1_comp_dimer UniProtKB/Swiss-Prot
  Skp1_comp_POZ UniProtKB/Swiss-Prot
KEGG Report rno:287280 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72936 IMAGE-MGC_LOAD
NCBI Gene 287280 ENTREZGENE
PANTHER PTHR11165 UniProtKB/Swiss-Prot
Pfam Skp1 UniProtKB/Swiss-Prot
  Skp1_POZ UniProtKB/Swiss-Prot
PhenoGen Skp1 PhenoGen
PIRSF E3_ubiquit_lig_SCF_Skp UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005828 RatGTEx
SMART Skp1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot
  SSF81382 UniProtKB/Swiss-Prot
UniProt A0A0G2K4X8 ENTREZGENE
  A0A8L2Q2U6 ENTREZGENE, UniProtKB/TrEMBL
  A6HEA2 ENTREZGENE, UniProtKB/TrEMBL
  Q6PEC4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-19 Skp1  S-phase kinase-associated protein 1  Skp1a  S-phase kinase-associated protein 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Skp1a  S-phase kinase-associated protein 1A      Symbol and Name status set to approved 1299863 APPROVED
2005-07-29 Skp1a  S-phase kinase-associated protein 1A      Symbol and Name status set to provisional 70820 PROVISIONAL