IgG-2a (gamma-2a immunoglobulin heavy chain) - Rat Genome Database

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Gene: IgG-2a (gamma-2a immunoglobulin heavy chain) Rattus norvegicus
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Symbol: IgG-2a
Name: gamma-2a immunoglobulin heavy chain
RGD ID: 1359626
Description: Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in antibacterial humoral response and complement activation, classical pathway. Predicted to be part of immunoglobulin complex, circulating. Orthologous to several human genes including IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)); IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker)); and IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker)); INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 3H-1,2-dithiole-3-thione.
Type: protein-coding
Previously known as: Ig gamma-2a-chain; immunoglobulin gamma-2a chain; MGC109083; MGC109134; MGC94466
RGD Orthologs
Human
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Genome Annotation Status: not in current annotation release
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
RGSC_v3.46138,346,448 - 138,452,787 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16138,352,639 - 139,081,445 (-)NCBI
Cytogenetic Map6q32NCBI


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Evolution of the rat immunoglobulin gamma heavy-chain gene family. Bruggemann M Gene 1988 Dec 30;74(2):473-82.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:3016742   PMID:12477932   PMID:22206666  


Genomics

Comparative Map Data
IgG-2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
RGSC_v3.46138,346,448 - 138,452,787 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16138,352,639 - 139,081,445 (-)NCBI
Cytogenetic Map6q32NCBI
IGHG4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814105,624,476 - 105,626,065 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14105,620,506 - 105,626,066 (-)EnsemblGRCh38hg38GRCh38
GRCh3714106,090,813 - 106,092,402 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614105,161,752 - 105,163,447 (-)NCBINCBI36Build 36hg18NCBI36
Cytogenetic Map14q32.33NCBI
CHM1_114106,087,113 - 106,088,702 (-)NCBICHM1_1
T2T-CHM13v2.01499,896,471 - 99,898,060 (-)NCBIT2T-CHM13v2.0

Markers in Region
RH134365  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26132,516,827 - 132,517,030 (+)MAPPERmRatBN7.2
Rnor_6.06138,239,343 - 138,239,545NCBIRnor6.0
Rnor_5.06147,231,799 - 147,232,001UniSTSRnor5.0
RGSC_v3.46138,442,358 - 138,442,560UniSTSRGSC3.4
Celera6130,043,266 - 130,043,468UniSTS
RH 3.4 Map8676.3UniSTS
Cytogenetic Map6q32UniSTS
Cytogenetic Map6q33UniSTS
RH127725  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26132,464,825 - 132,465,019 (+)MAPPERmRatBN7.2
mRatBN7.2647,904,641 - 47,904,835 (+)MAPPERmRatBN7.2
Rnor_6.0650,598,166 - 50,598,359NCBIRnor6.0
Rnor_6.06138,190,294 - 138,190,487NCBIRnor6.0
Rnor_5.0659,273,393 - 59,273,586UniSTSRnor5.0
Rnor_5.06147,182,750 - 147,182,943UniSTSRnor5.0
RGSC_v3.4649,185,154 - 49,185,347UniSTSRGSC3.4
RGSC_v3.46138,387,490 - 138,387,683UniSTSRGSC3.4
Celera647,106,650 - 47,106,843UniSTS
RH 3.4 Map6284.7UniSTS
Cytogenetic Map6q32UniSTS
Cytogenetic Map6q16UniSTS
AI326478  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26132,516,866 - 132,516,948 (+)MAPPERmRatBN7.2
Rnor_6.06138,239,382 - 138,239,463NCBIRnor6.0
Rnor_5.06147,231,838 - 147,231,919UniSTSRnor5.0
RGSC_v3.46138,442,397 - 138,442,478UniSTSRGSC3.4
Celera6130,043,305 - 130,043,386UniSTS
Cytogenetic Map6q32UniSTS
Cytogenetic Map6q33UniSTS
M-04725  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26132,526,630 - 132,526,738 (+)MAPPERmRatBN7.2
Rnor_6.06138,249,146 - 138,249,253NCBIRnor6.0
Rnor_5.06147,241,602 - 147,241,709UniSTSRnor5.0
RGSC_v3.46138,452,161 - 138,452,268UniSTSRGSC3.4
Celera6130,052,813 - 130,052,920UniSTS
Cytogenetic Map6q32UniSTS
Cytogenetic Map6q33UniSTS
AA848883  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86138,245,789 - 138,245,954 (+)Marker Load Pipeline
mRatBN7.26132,424,751 - 132,424,917 (+)MAPPERmRatBN7.2
Rnor_6.06138,146,938 - 138,147,103NCBIRnor6.0
Rnor_5.06147,140,241 - 147,140,406UniSTSRnor5.0
RGSC_v3.46138,346,498 - 138,346,663UniSTSRGSC3.4
Celera6129,955,297 - 129,955,462UniSTS
RH 3.4 Map6781.2UniSTS
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression


Sequence


Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20760-F1-model_v2 AlphaFold P20760 1-322 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359626 AgrOrtholog
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7123713 IMAGE-MGC_LOAD
  IMAGE:7365825 IMAGE-MGC_LOAD
  IMAGE:7375893 IMAGE-MGC_LOAD
  IMAGE:7382505 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  Immune_Resp_Modulators UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:109023 IMAGE-MGC_LOAD
  MGC:109083 IMAGE-MGC_LOAD
  MGC:109134 IMAGE-MGC_LOAD
  MGC:95049 IMAGE-MGC_LOAD
NCBI Gene 367586 ENTREZGENE
PANTHER IMMUNOGLOBULIN HEAVY CONSTANT GAMMA 1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAPASIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V-set UniProtKB/TrEMBL
PhenoGen IgG-2a PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGv UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt IGG2A_RAT UniProtKB/Swiss-Prot
  Q5M842_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-29 IgG-2a  gamma-2a immunoglobulin heavy chain      Symbol and Name status set to provisional 70820 PROVISIONAL