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Gene: Wsb2 (WD repeat and SOCS box-containing 2) Rattus norvegicus

Analyze

Symbol:

Wsb2

Name:

WD repeat and SOCS box-containing 2

RGD ID:

1359599

Description:

Predicted to be involved in protein polyubiquitination. Orthologous to human WSB2 (WD repeat and SOCS box containing 2); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

MGC93822; WD repeat and SOCS box-containing protein 2; WD SOCS-box protein 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	WSB2 (WD repeat and SOCS box containing 2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Wsb2 (WD repeat and SOCS box-containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Wsb2 (WD repeat and SOCS box containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	WSB2 (WD repeat and SOCS box containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	WSB2 (WD repeat and SOCS box containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Wsb2 (WD repeat and SOCS box containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	WSB2 (WD repeat and SOCS box containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	WSB2 (WD repeat and SOCS box containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Wsb2 (WD repeat and SOCS box containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Wsb2 (WD repeat and SOCS box containing 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	WSB2 (WD repeat and SOCS box containing 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	WSB2 (WD repeat and SOCS box containing 2)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Wsb2 (WD repeat and SOCS box-containing 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Wsb2 (WD repeat and SOCS box-containing 2)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	wsb2 (WD repeat and SOCS box containing 2)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	wsb2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	wsb2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	44,878,483 - 44,899,474 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	44,878,509 - 44,899,474 (-)	Ensembl				GRCr8
mRatBN7.2	12	39,217,645 - 39,238,634 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	39,217,648 - 39,238,640 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	40,392,944 - 40,414,017 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	41,006,754 - 41,027,827 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	40,059,729 - 40,080,802 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	44,941,655 - 44,962,679 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	44,942,443 - 44,962,656 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	46,762,961 - 46,783,174 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	40,406,890 - 40,427,103 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	40,861,675 - 40,881,847 (-)	NCBI		Celera
RGSC_v3.1	12	40,270,278 - 40,290,491 (-)	NCBI
Cytogenetic Map	12	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

acrolein (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlormequat chloride (EXP)

choline (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

diazinon (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP,ISO)

diethylstilbestrol (ISO)

ethanol (ISO)

fenofibrate (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

furan (EXP)

gentamycin (EXP)

GSK-J4 (ISO)

hydrogen cyanide (ISO)

hydrogen peroxide (ISO)

indometacin (ISO)

L-methionine (ISO)

lead diacetate (ISO)

lead(0) (ISO)

leflunomide (EXP)

methylseleninic acid (ISO)

nimesulide (EXP)

okadaic acid (ISO)

ozone (ISO)

paclitaxel (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

potassium cyanide (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

temozolomide (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

triptonide (ISO)

uranium atom (ISO)

valproic acid (ISO)

vincaleukoblastine (ISO)

zinc protoporphyrin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	null	JRS Domain-based curation
3.	The SOCS box: a tale of destruction and degradation.	Kile BT, etal., Trends Biochem Sci 2002 May;27(5):235-41.
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:16751776

Genomics

Comparative Map Data

Wsb2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	44,878,483 - 44,899,474 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	44,878,509 - 44,899,474 (-)	Ensembl				GRCr8
mRatBN7.2	12	39,217,645 - 39,238,634 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	39,217,648 - 39,238,640 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	40,392,944 - 40,414,017 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	41,006,754 - 41,027,827 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	40,059,729 - 40,080,802 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	44,941,655 - 44,962,679 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	44,942,443 - 44,962,656 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	46,762,961 - 46,783,174 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	40,406,890 - 40,427,103 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	40,861,675 - 40,881,847 (-)	NCBI		Celera
RGSC_v3.1	12	40,270,278 - 40,290,491 (-)	NCBI
Cytogenetic Map	12	q16	NCBI

WSB2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	118,032,687 - 118,062,174 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	118,032,687 - 118,062,430 (-)	Ensembl			hg38	GRCh38
GRCh37	12	118,470,492 - 118,499,979 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	116,954,875 - 116,983,334 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	116,933,218 - 116,961,671	NCBI
Celera	12	118,100,954 - 118,120,938 (-)	NCBI		Celera
Cytogenetic Map	12	q24.23	NCBI
HuRef	12	115,480,817 - 115,510,277 (-)	NCBI		HuRef
CHM1_1	12	118,438,174 - 118,467,675 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	118,019,987 - 118,049,474 (-)	NCBI		T2T-CHM13v2.0

Wsb2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	117,495,370 - 117,516,666 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	117,495,369 - 117,516,666 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	117,357,305 - 117,378,601 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	117,357,304 - 117,378,601 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	117,807,314 - 117,828,598 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	117,618,335 - 117,639,619 (+)	NCBI		MGSCv36	mm8
Celera	5	114,445,657 - 114,469,544 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	56.88	NCBI

Wsb2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	13,312,560 - 13,328,254 (+)	Ensembl
ChiLan1.0	NW_004955455	13,313,072 - 13,324,496 (+)	NCBI	ChiLan1.0	ChiLan1.0

WSB2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	126,097,330 - 126,125,578 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	126,093,772 - 126,121,984 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	115,612,109 - 115,640,781 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	118,990,085 - 119,019,807 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	118,990,085 - 119,019,416 (-)	Ensembl			panPan2	panpan1.1

WSB2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	14,440,035 - 14,456,158 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	14,441,304 - 14,497,174 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	14,432,910 - 14,451,641 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	14,701,819 - 14,720,552 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	14,701,835 - 14,759,370 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	14,666,690 - 14,685,416 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	14,738,532 - 14,757,489 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	14,773,882 - 14,792,614 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Wsb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	154,743,867 - 154,764,882 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936558	4,720,389 - 4,734,302 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936558	4,720,460 - 4,735,535 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

WSB2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	34,609,075 - 34,632,269 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	34,608,965 - 34,630,980 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	36,770,292 - 36,791,306 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

WSB2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	113,368,807 - 113,397,648 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	113,370,198 - 113,398,321 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	131,710,241 - 131,739,081 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Wsb2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	15,417,656 - 15,439,283 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624747	15,417,579 - 15,443,496 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Wsb2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	36,451,239 - 36,471,951 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Wsb2
99 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	46
Count of miRNA genes:	41
Interacting mature miRNAs:	43
Transcripts:	ENSRNOT00000001499
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
8693635	Alc28	Alcohol consumption QTL 28	2.7	0.439	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	50386405	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	37764145	51558799	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1556747	Calcic1	Intracellular calcium level QTL 1		3.6	platelet calcium amount (VT:0010500)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	33700432	51558799	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
8693658	Alc33	Alcohol consumption QTL 33	2.1	0.68	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	49212240	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
631543	Bp83	Blood pressure QTL 83	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	44139558	52308831	Rat

Markers in Region

AA956464

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	12	44,879,337 - 44,879,627 (+)	Marker Load Pipeline
mRatBN7.2	12	39,218,499 - 39,218,789 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	44,942,510 - 44,942,799	NCBI	Rnor6.0
Rnor_5.0	12	46,763,028 - 46,763,317	UniSTS	Rnor5.0
RGSC_v3.4	12	40,406,957 - 40,407,246	UniSTS	RGSC3.4
Celera	12	40,861,742 - 40,862,031	UniSTS
RH 3.4 Map	12	753.3	UniSTS
Cytogenetic Map	12	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001007616	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001415754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271211	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC081901	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ603971	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001499 ⟹ ENSRNOP00000001499

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	39,218,433 - 39,238,541 (-)	Ensembl
Rnor_6.0 Ensembl	12	44,942,443 - 44,962,656 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096106 ⟹ ENSRNOP00000081254

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	39,217,648 - 39,232,461 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096120 ⟹ ENSRNOP00000095227

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	39,217,648 - 39,238,620 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108322 ⟹ ENSRNOP00000097041

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	44,878,509 - 44,899,474 (-)	Ensembl
mRatBN7.2 Ensembl	12	39,217,850 - 39,238,640 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112123 ⟹ ENSRNOP00000077859

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	39,217,648 - 39,232,502 (-)	Ensembl

RefSeq Acc Id:

NM_001007616 ⟹ NP_001007617

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	44,878,483 - 44,899,474 (-)	NCBI
mRatBN7.2	12	39,217,645 - 39,238,634 (-)	NCBI
Rnor_6.0	12	44,942,443 - 44,962,679 (-)	NCBI
Rnor_5.0	12	46,762,961 - 46,783,174 (-)	NCBI
RGSC_v3.4	12	40,406,890 - 40,427,103 (-)	RGD
Celera	12	40,861,675 - 40,881,847 (-)	NCBI

Sequence:

show sequence

GGCGCGGAATGAAGGCCCGCGGCCCTGGGGGCTGAGGCGCCCGCCGCCTGGGGCGGGCCGCGCG
TCCTCATGGAGGCCGGAGAGGAACCCCTACTGCTGGCTGAACTCAAGCCCGGGCGCCCCCACCA
GTTTGATTGGAAGTCAAGCTGTGAAACCTGGAGTGTGGCCTTTTCTCCAGATGGTTCCTGGTTC
GCCTGGTCTCAAGGACACTGCGTGGTCAAGCTGGTACCCTGGCCCTTAGAGGAGCAGTTTATCC
CTAAAGGATTCGAAGCCAAAAGCCGAAGCAGCAAGAATGATTCAAAAGGACGGGGCAGTCTGAA
GGAGAAGACGCTGGACTGTGGCCAGATTGTATGGGGGTTGGCCTTCAGCCCATGGCCCTCTCCA
CCCAGCAGGAAACTCTGGCTCCGTCACCATCCCCAGGTGCCTGATGTCTCCTGCCTGATCCTGG
CCACAGGTCTCAACGACGGACAGATCAAGATTTGGGAGGTGCAGACAGGGCTCCTGCTGCTGAA
TCTTTCTGGCCACCAGGATGTTGTGAGAGATCTGAGCTTCACGCCCAATGGCAGCTTGATTTTG
GTCTCTGCATCCCGGGATAAGACTCTTCGCATTTGGGACCTGAATAAGCACGGTAAGCAGATCC
AGGTGCTGTCCGGCCATCTGCAGTGGGTTTACTGCTGCTCCATCTCCCCTGACTGCAGCATGCT
GTGCTCTGCCGCTGGTGAGAAGTCGGTCTTTCTGTGGAGCATGCGATCTTACACACTAATCCGG
AAACTAGAAGGCCACCAAAGCAGTGTTGTCTCCTGTGACTTCTCTCCCGATTCCGCCTTGCTCG
TTACAGCTTCGTATGACACCAGTGTGATCATGTGGGACCCCTACACCGGCGAGAGGCTGAGGTC
ACTTCATCACACTCAGCTCGAAGCTCCCGTGGATGACAGTGATGTCCACATGAGCTCCCTGCGG
TCTGTGTGCTTCTCCCCTGAAGGCCTATATCTTGCTACAGTGGCAGACGACAGGCTCCTCAGGA
TCTGGGCTCTGGAACTGAAGGCTCCCGTTGCCTTTGCTCCTATGACCAATGGTCTCTGCTGCAC
ATTCTTCCCACACGGTGGAGTTATTGCCACAGGGACGAGAGATGGCCATGTCCAGTTCTGGACG
GCTCCGCGAGTCCTGTCCTCACTGAAGCACTTATGCAGGAAAGCCCTCCGACGTTTCCTGACTA
CGTATCAAGTCCTAGCACTGCCAATCCCCAAGAAGATGAAAGACTTCCTCACGTACAGGACTTT
GTAGCAGTGCCAGCCCCCATCTCCTGCAGCAGAACCAGTACAAGGGACTGGCGAGGATGGAGCC
AGGCAGACCACGCTGGACCAGTGTGGACCTTCCTCCCCATGGCATGTGCAAGTAGGTCTGAGTG
ATCCCACTTCCGTGGTGCCAGCCTTACCTCGCCTTCGTCCGTTGTGAGCAGCCTTTGTCAGTCT
AGTTGTGTTGAAGCCAAGTGCAGTTGTGGAAGTCGTGTGGGTAATAAAAGCAAGCAGGCTCCAG
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_001415754 ⟹ NP_001402683

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	44,878,483 - 44,899,474 (-)	NCBI
mRatBN7.2	12	39,217,645 - 39,238,634 (-)	NCBI

RefSeq Acc Id:

XM_063271211 ⟹ XP_063127281

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	44,878,638 - 44,893,285 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001007617	(Get FASTA)	NCBI Sequence Viewer
	NP_001402683	(Get FASTA)	NCBI Sequence Viewer
	XP_063127281	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81901	(Get FASTA)	NCBI Sequence Viewer
	EDM13826	(Get FASTA)	NCBI Sequence Viewer
	EDM13827	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000097041
	ENSRNOP00000097041.2

RefSeq Acc Id:	NP_001007617 ⟸ NM_001007616
- Peptide Label:	isoform 1
- UniProtKB:	Q66HE3 (UniProtKB/TrEMBL), A6J1N8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEAGEEPLLLAELKPGRPHQFDWKSSCETWSVAFSPDGSWFAWSQGHCVVKLVPWPLEEQFIPK GFEAKSRSSKNDSKGRGSLKEKTLDCGQIVWGLAFSPWPSPPSRKLWLRHHPQVPDVSCLILAT GLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPNGSLILVSASRDKTLRIWDLNKHGKQIQV LSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVT ASYDTSVIMWDPYTGERLRSLHHTQLEAPVDDSDVHMSSLRSVCFSPEGLYLATVADDRLLRIW ALELKAPVAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFWTAPRVLSSLKHLCRKALRRFLTTY QVLALPIPKKMKDFLTYRTL hide sequence

Ensembl Acc Id:

ENSRNOP00000001499 ⟸ ENSRNOT00000001499

Ensembl Acc Id:

ENSRNOP00000095227 ⟸ ENSRNOT00000096120

Ensembl Acc Id:

ENSRNOP00000077859 ⟸ ENSRNOT00000112123

Ensembl Acc Id:

ENSRNOP00000081254 ⟸ ENSRNOT00000096106

Ensembl Acc Id:

ENSRNOP00000097041 ⟸ ENSRNOT00000108322

RefSeq Acc Id:	NP_001402683 ⟸ NM_001415754
- Peptide Label:	isoform 2

RefSeq Acc Id:	XP_063127281 ⟸ XM_063271211
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5Y8A6 (UniProtKB/TrEMBL), A6J1N8 (UniProtKB/TrEMBL), F7F7B9 (UniProtKB/TrEMBL)

Protein Domains

SOCS box

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q66HE3-F1-model_v2	AlphaFold	Q66HE3	1-404	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698675

Promoter ID:

EPDNEW_R9200

Type:

initiation region

Name:

Wsb2_1

Description:

WD repeat and SOCS box-containing 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	44,962,646 - 44,962,706	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359599	AgrOrtholog
BioCyc Gene	G2FUF-19063	BioCyc
Ensembl Genes	ENSRNOG00000001135	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000108322	ENTREZGENE
	ENSRNOT00000108322.2	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
	SOCS box	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7110808	IMAGE-MGC_LOAD
InterPro	G-protein_beta_WD-40_rep_reg	UniProtKB/TrEMBL
	SOCS_box_dom_like	UniProtKB/TrEMBL
	SOCS_C	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_CS	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
	WSB_SOCS-box_domain	UniProtKB/TrEMBL
KEGG Report	rno:288692	UniProtKB/TrEMBL
MGC_CLONE	MGC:93822	IMAGE-MGC_LOAD
NCBI Gene	288692	ENTREZGENE
PANTHER	WD REPEAT AND SOCS BOX-CONTAINING PROTEIN 2	UniProtKB/TrEMBL
	WD40 REPEAT PROTEIN	UniProtKB/TrEMBL
Pfam	SOCS_box	UniProtKB/TrEMBL
	WD40	UniProtKB/TrEMBL
PhenoGen	Wsb2	PhenoGen
PRINTS	GPROTEINBRPT	UniProtKB/TrEMBL
PROSITE	SOCS	UniProtKB/TrEMBL
	WD_REPEATS_1	UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001135	RatGTEx
SMART	SOCS	UniProtKB/TrEMBL
	SOCS_box	UniProtKB/TrEMBL
	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	SSF158235	UniProtKB/TrEMBL
	WD40_like	UniProtKB/TrEMBL
UniProt	A0A8I5Y8A6	ENTREZGENE
	A0A8I6AQQ7_RAT	UniProtKB/TrEMBL
	A6J1N7_RAT	UniProtKB/TrEMBL
	A6J1N8	ENTREZGENE, UniProtKB/TrEMBL
	F7F7B9	ENTREZGENE
	Q66HE3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Wsb2	WD repeat and SOCS box-containing 2		WD SOCS-box protein 2	Name updated	1299863	APPROVED
2005-07-29	Wsb2	WD SOCS-box protein 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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