Xrcc4 (X-ray repair cross complementing 4) - Rat Genome Database

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Gene: Xrcc4 (X-ray repair cross complementing 4) Rattus norvegicus
Analyze
Symbol: Xrcc4
Name: X-ray repair cross complementing 4
RGD ID: 1359573
Description: Predicted to enable FHA domain binding activity and identical protein binding activity. Predicted to contribute to 3' overhang single-stranded DNA endodeoxyribonuclease activity. Involved in cellular response to lithium ion. Predicted to be located in chromosome, telomeric region; cytosol; and nucleoplasm. Predicted to be part of DNA ligase IV complex; DNA-dependent protein kinase-DNA ligase 4 complex; and ERCC4-ERCC1 complex. Predicted to be active in cytoplasm; nucleus; and site of double-strand break. Human ortholog(s) of this gene implicated in multiple myeloma; salivary gland adenoid cystic carcinoma; and salivary gland carcinoma. Orthologous to human XRCC4 (X-ray repair cross complementing 4); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DNA repair protein XRCC4; MGC95022; X-ray repair complementing defective repair in Chinese hamster cells 4; X-ray repair cross complementing protein 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8222,686,506 - 22,932,929 (-)NCBIGRCr8
mRatBN7.2220,948,464 - 21,197,705 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl220,951,200 - 21,197,808 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx227,992,235 - 28,226,236 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0226,092,544 - 26,326,544 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0220,876,366 - 21,122,020 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0218,674,496 - 18,927,463 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl218,677,220 - 18,927,365 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0218,550,304 - 18,803,313 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4219,904,490 - 20,158,358 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1219,824,860 - 20,078,727 (-)NCBI
Celera217,092,971 - 17,325,919 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3-chlorophenol  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
aphidicolin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
chlorpromazine  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
coumarin  (ISO)
curcumin  (ISO)
diarsenic trioxide  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
etoposide  (ISO)
floxuridine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gallic acid  (ISO)
gentamycin  (EXP)
hydroxyurea  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lithium chloride  (EXP)
melatonin  (ISO)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
monocrotaline  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
rifampicin  (ISO)
sodium arsenite  (ISO)
taurine  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (EXP,ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Gao Y, etal., Nature 2000 Apr 20;404(6780):897-900.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Variation in DNA repair genes XRCC3, XRCC4, XRCC5 and susceptibility to myeloma. Hayden PJ, etal., Hum Mol Genet. 2007 Dec 15;16(24):3117-27. Epub 2007 Sep 26.
4. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Lieber MR Annu Rev Biochem. 2010;79:181-211. doi: 10.1146/annurev.biochem.052308.093131.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. Genetic variants in DNA double-strand break repair genes and risk of salivary gland carcinoma: a case-control study. Xu L, etal., PLoS One. 2015 Jun 2;10(6):e0128753. doi: 10.1371/journal.pone.0128753. eCollection 2015.
13. Lithium chloride protects retinal neurocytes from nutrient deprivation by promoting DNA non-homologous end-joining. Zhuang J, etal., Biochem Biophys Res Commun. 2009 Mar 13;380(3):650-4. Epub 2009 Jan 31.
Additional References at PubMed
PMID:9242410   PMID:9259561   PMID:9809069   PMID:9875844   PMID:10716994   PMID:11751629   PMID:12517771   PMID:12589063   PMID:14690602   PMID:15194694   PMID:16169070   PMID:17713479  
PMID:20383123   PMID:21070942   PMID:21768349   PMID:25416956   PMID:25941166   PMID:27644316   PMID:31515488  


Genomics

Comparative Map Data
Xrcc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8222,686,506 - 22,932,929 (-)NCBIGRCr8
mRatBN7.2220,948,464 - 21,197,705 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl220,951,200 - 21,197,808 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx227,992,235 - 28,226,236 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0226,092,544 - 26,326,544 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0220,876,366 - 21,122,020 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0218,674,496 - 18,927,463 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl218,677,220 - 18,927,365 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0218,550,304 - 18,803,313 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4219,904,490 - 20,158,358 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1219,824,860 - 20,078,727 (-)NCBI
Celera217,092,971 - 17,325,919 (-)NCBICelera
Cytogenetic Map2q12NCBI
XRCC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38583,077,547 - 83,374,473 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl583,077,498 - 83,353,787 (+)EnsemblGRCh38hg38GRCh38
GRCh37582,373,366 - 82,649,579 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36582,409,073 - 82,685,335 (+)NCBINCBI36Build 36hg18NCBI36
Build 34582,409,072 - 82,685,333NCBI
Celera578,277,921 - 78,554,649 (+)NCBICelera
Cytogenetic Map5q14.2NCBI
HuRef577,581,701 - 77,857,876 (+)NCBIHuRef
CHM1_1581,806,225 - 82,082,296 (+)NCBICHM1_1
T2T-CHM13v2.0583,566,676 - 83,868,132 (+)NCBIT2T-CHM13v2.0
Xrcc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391389,997,033 - 90,237,727 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1389,922,146 - 90,237,727 (-)EnsemblGRCm39 Ensembl
GRCm381389,848,914 - 90,089,608 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1389,774,027 - 90,089,608 (-)EnsemblGRCm38mm10GRCm38
MGSCv371389,988,519 - 90,229,213 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361390,323,160 - 90,563,762 (-)NCBIMGSCv36mm8
Celera1390,272,259 - 90,272,798 (-)ENTREZGENECelera
Cytogenetic Map13C3NCBI
cM Map1345.5NCBI
Xrcc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541827,173,659 - 27,426,264 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541827,174,510 - 27,426,245 (-)NCBIChiLan1.0ChiLan1.0
XRCC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2431,949,872 - 32,224,685 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1530,103,497 - 30,378,310 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0531,927,463 - 32,202,394 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1532,246,959 - 32,521,724 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl532,246,320 - 32,521,490 (-)Ensemblpanpan1.1panPan2
XRCC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1324,316,598 - 24,547,463 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl324,269,974 - 24,533,465 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha325,552,786 - 25,784,876 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0324,221,065 - 24,459,863 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl324,223,262 - 24,459,740 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1324,183,704 - 24,415,864 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0324,144,360 - 24,382,706 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0324,431,265 - 24,663,456 (-)NCBIUU_Cfam_GSD_1.0
Xrcc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213180,130,706 - 180,377,405 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364692,248,039 - 2,495,226 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364692,248,367 - 2,495,215 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VCAN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl291,384,391 - 91,811,208 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1291,358,348 - 91,643,697 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2293,441,303 - 93,765,821 (+)NCBISscrofa10.2Sscrofa10.2susScr3
XRCC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1477,182,569 - 77,468,786 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl477,182,793 - 77,468,775 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604926,084,964 - 26,376,614 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Xrcc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247433,317,351 - 3,552,161 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247433,299,329 - 3,549,182 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Xrcc4
1898 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:223
Count of miRNA genes:151
Interacting mature miRNAs:172
Transcripts:ENSRNOT00000045850
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
61368Mcs1Mammary carcinoma susceptibility QTL 14.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777223319447Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat

Markers in Region
D10Ulb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2221,143,394 - 21,144,889 (+)MAPPERmRatBN7.2
mRatBN7.2105,796,328 - 5,796,484 (+)MAPPERmRatBN7.2
Rnor_6.0105,872,003 - 5,872,158NCBIRnor6.0
Rnor_6.0218,873,175 - 18,874,669NCBIRnor6.0
Rnor_5.0104,690,107 - 4,690,262UniSTSRnor5.0
Rnor_5.0218,748,955 - 18,750,449UniSTSRnor5.0
RGSC_v3.4220,104,168 - 20,105,662UniSTSRGSC3.4
RGSC_v3.4105,755,479 - 5,755,634UniSTSRGSC3.4
Celera104,807,109 - 4,807,263UniSTS
Celera217,271,726 - 17,273,220UniSTS
Cytogenetic Map2q12UniSTS
Cytogenetic Map10q11UniSTS
BI303647  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2221,195,901 - 21,196,021 (+)MAPPERmRatBN7.2
Rnor_6.0218,925,682 - 18,925,801NCBIRnor6.0
Rnor_5.0218,801,462 - 18,801,581UniSTSRnor5.0
RGSC_v3.4220,156,675 - 20,156,794UniSTSRGSC3.4
Celera217,324,236 - 17,324,355UniSTS
Cytogenetic Map2q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001006999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC083848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000045850   ⟹   ENSRNOP00000048754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl220,951,200 - 21,191,701 (-)Ensembl
Rnor_6.0 Ensembl218,677,220 - 18,927,365 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097360   ⟹   ENSRNOP00000085204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl220,951,202 - 21,197,546 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114855   ⟹   ENSRNOP00000077554
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl220,951,201 - 21,197,808 (-)Ensembl
RefSeq Acc Id: NM_001006999   ⟹   NP_001007000
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8222,686,506 - 22,932,813 (-)NCBI
mRatBN7.2220,951,198 - 21,197,585 (-)NCBI
Rnor_6.0218,677,218 - 18,927,365 (-)NCBI
Rnor_5.0218,550,304 - 18,803,313 (-)NCBI
RGSC_v3.4219,904,490 - 20,158,358 (-)RGD
Celera217,092,971 - 17,325,919 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231751   ⟹   XP_006231813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8222,686,506 - 22,932,743 (-)NCBI
mRatBN7.2220,948,464 - 21,197,560 (-)NCBI
Rnor_6.0218,674,496 - 18,927,340 (-)NCBI
Rnor_5.0218,550,304 - 18,803,313 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760636   ⟹   XP_008758858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8222,686,506 - 22,932,929 (-)NCBI
mRatBN7.2220,948,464 - 21,197,705 (-)NCBI
Rnor_6.0218,674,496 - 18,927,463 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760637   ⟹   XP_008758859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8222,686,506 - 22,932,743 (-)NCBI
mRatBN7.2220,948,464 - 21,197,560 (-)NCBI
Rnor_6.0218,674,496 - 18,927,340 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039102165   ⟹   XP_038958093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8222,686,506 - 22,931,995 (-)NCBI
mRatBN7.2220,948,464 - 21,197,051 (-)NCBI
RefSeq Acc Id: XM_039102166   ⟹   XP_038958094
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8222,686,506 - 22,932,416 (-)NCBI
mRatBN7.2220,948,464 - 21,197,370 (-)NCBI
RefSeq Acc Id: XM_039102168   ⟹   XP_038958096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8222,686,506 - 22,930,298 (-)NCBI
mRatBN7.2220,948,464 - 21,195,085 (-)NCBI
RefSeq Acc Id: XM_063281710   ⟹   XP_063137780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8222,686,506 - 22,931,995 (-)NCBI
RefSeq Acc Id: XM_063281711   ⟹   XP_063137781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8222,686,506 - 22,932,416 (-)NCBI
RefSeq Acc Id: XM_063281712   ⟹   XP_063137782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8222,815,991 - 22,932,929 (-)NCBI
RefSeq Acc Id: XM_063281713   ⟹   XP_063137783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8222,815,991 - 22,932,929 (-)NCBI
RefSeq Acc Id: XM_063281714   ⟹   XP_063137784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8222,815,991 - 22,932,743 (-)NCBI
RefSeq Acc Id: NP_001007000   ⟸   NM_001006999
- UniProtKB: Q5XI44 (UniProtKB/TrEMBL),   A6I4N6 (UniProtKB/TrEMBL),   F7EEB9 (UniProtKB/TrEMBL),   A0A8I6A2T0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231813   ⟸   XM_006231751
- Peptide Label: isoform X2
- UniProtKB: Q5XI44 (UniProtKB/TrEMBL),   A6I4N6 (UniProtKB/TrEMBL),   F7EEB9 (UniProtKB/TrEMBL),   A0A8I6A2T0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758858   ⟸   XM_008760636
- Peptide Label: isoform X1
- UniProtKB: F7EEB9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758859   ⟸   XM_008760637
- Peptide Label: isoform X1
- UniProtKB: F7EEB9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000048754   ⟸   ENSRNOT00000045850
RefSeq Acc Id: XP_038958094   ⟸   XM_039102166
- Peptide Label: isoform X1
- UniProtKB: F7EEB9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958093   ⟸   XM_039102165
- Peptide Label: isoform X1
- UniProtKB: F7EEB9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958096   ⟸   XM_039102168
- Peptide Label: isoform X2
- UniProtKB: Q5XI44 (UniProtKB/TrEMBL),   A6I4N6 (UniProtKB/TrEMBL),   F7EEB9 (UniProtKB/TrEMBL),   A0A8I6A2T0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000085204   ⟸   ENSRNOT00000097360
Ensembl Acc Id: ENSRNOP00000077554   ⟸   ENSRNOT00000114855
RefSeq Acc Id: XP_063137781   ⟸   XM_063281711
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A2T0 (UniProtKB/TrEMBL),   A6I4N6 (UniProtKB/TrEMBL),   Q5XI44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137780   ⟸   XM_063281710
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A2T0 (UniProtKB/TrEMBL),   A6I4N6 (UniProtKB/TrEMBL),   Q5XI44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137783   ⟸   XM_063281713
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063137782   ⟸   XM_063281712
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063137784   ⟸   XM_063281714
- Peptide Label: isoform X4
Protein Domains
XRCC4 C-terminal   XRCC4 coiled-coil   XRCC4 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XI44-F1-model_v2 AlphaFold Q5XI44 1-323 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691052
Promoter ID:EPDNEW_R1577
Type:single initiation site
Name:Xrcc4_1
Description:X-ray repair cross complementing 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0218,927,417 - 18,927,477EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359573 AgrOrtholog
BioCyc Gene G2FUF-54902 BioCyc
Ensembl Genes ENSRNOG00000029966 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045850.3 UniProtKB/TrEMBL
  ENSRNOT00000097360.1 UniProtKB/TrEMBL
  ENSRNOT00000114855.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.370 UniProtKB/TrEMBL
  2.170.210.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7122361 IMAGE-MGC_LOAD
InterPro DNA_ds_break_repair_XRCC4 UniProtKB/TrEMBL
  XRCC4-like_C UniProtKB/TrEMBL
  XRCC4-like_N_sf UniProtKB/TrEMBL
  XRCC4_C UniProtKB/TrEMBL
  XRCC4_CC UniProtKB/TrEMBL
  XRCC4_N UniProtKB/TrEMBL
  XRCC4_N UniProtKB/TrEMBL
KEGG Report rno:309995 UniProtKB/TrEMBL
MGC_CLONE MGC:95022 IMAGE-MGC_LOAD
NCBI Gene 309995 ENTREZGENE
PANTHER DNA REPAIR PROTEIN XRCC4 UniProtKB/TrEMBL
  PTHR28559 UniProtKB/TrEMBL
Pfam XRCC4 UniProtKB/TrEMBL
  XRCC4_C UniProtKB/TrEMBL
  XRCC4_CC UniProtKB/TrEMBL
PharmGKB XRCC4 RGD
PhenoGen Xrcc4 PhenoGen
RatGTEx ENSRNOG00000029966 RatGTEx
Superfamily-SCOP XRCC4, C-terminal oligomerization domain UniProtKB/TrEMBL
  XRCC4_N UniProtKB/TrEMBL
UniProt A0A8I5Y5Z6_RAT UniProtKB/TrEMBL
  A0A8I6A2T0 ENTREZGENE, UniProtKB/TrEMBL
  A6I4N6 ENTREZGENE, UniProtKB/TrEMBL
  F7EEB9 ENTREZGENE, UniProtKB/TrEMBL
  Q5XI44 ENTREZGENE
UniProt Secondary Q5XI44 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-08 Xrcc4  X-ray repair cross complementing 4  Xrcc4  X-ray repair complementing defective repair in Chinese hamster cells 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Xrcc4  X-ray repair complementing defective repair in Chinese hamster cells 4    X-ray repair cross complementing protein 4  Name updated 1299863 APPROVED
2005-07-29 Xrcc4  X-ray repair cross complementing protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL